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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 12

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Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome.
Gelfand BD, Wright CB, Kim Y, Yasuma T, Yasuma R, Li S, Fowler BJ, Bastos-Carvalho A, Kerur N, Uittenbogaard A, Han YS, Lou D, Kleinman ME, McDonald WH, Núñez G, Georgel P, Dunaief JL, Ambati J
(2015) Cell Rep 11: 1686-93
MeSH Terms: Alu Elements, Animals, Carrier Proteins, Caspase 1, DEAD-box RNA Helicases, Inflammasomes, Iron, Mice, Mice, Inbred C57BL, NLR Family, Pyrin Domain-Containing 3 Protein, RNA-Binding Proteins, Retinal Pigment Epithelium, Ribonuclease III
Added January 26, 2016
0 Communities
1 Members
0 Resources
13 MeSH Terms
Spleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection.
Callaway JB, Smith SA, McKinnon KP, de Silva AM, Crowe JE, Ting JP
(2015) J Biol Chem 290: 17306-20
MeSH Terms: Antibodies, Viral, Antibody-Dependent Enhancement, Antigen-Antibody Complex, Carrier Proteins, Caspase 1, Cells, Cultured, Dengue, Dengue Virus, Glyburide, Humans, Interleukin-1beta, Intracellular Signaling Peptides and Proteins, MAP Kinase Signaling System, Monocytes, NLR Family, Pyrin Domain-Containing 3 Protein, Protein-Tyrosine Kinases, RNA, Messenger, RNA, Small Interfering, Syk Kinase, Virus Replication
Added January 26, 2016
0 Communities
1 Members
0 Resources
20 MeSH Terms
Dysregulation of Escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection.
Nagamatsu K, Hannan TJ, Guest RL, Kostakioti M, Hadjifrangiskou M, Binkley J, Dodson K, Raivio TL, Hultgren SJ
(2015) Proc Natl Acad Sci U S A 112: E871-80
MeSH Terms: Acute Disease, Animals, Apoptosis, Bacterial Proteins, Carrier Proteins, Caspase 1, Chronic Disease, Colony Count, Microbial, Disease Progression, Enzyme Activation, Escherichia coli Infections, Escherichia coli Proteins, Female, Gene Expression Regulation, Bacterial, Hemolysin Proteins, Humans, Inflammasomes, Interleukin-1beta, Mice, Models, Biological, NLR Family, Pyrin Domain-Containing 3 Protein, Signal Transduction, Urinary Bladder, Urinary Tract Infections, Uropathogenic Escherichia coli, Virulence
Added February 16, 2016
0 Communities
1 Members
0 Resources
26 MeSH Terms
Preconditioning mesenchymal stem cells with caspase inhibition and hyperoxia prior to hypoxia exposure increases cell proliferation.
Saini U, Gumina RJ, Wolfe B, Kuppusamy ML, Kuppusamy P, Boudoulas KD
(2013) J Cell Biochem 114: 2612-23
MeSH Terms: Amino Acid Chloromethyl Ketones, Animals, Caspase 1, Caspase 3, Caspase 6, Caspase 7, Caspase 9, Cell Hypoxia, Cell Proliferation, Cells, Cultured, Male, Mesenchymal Stem Cells, Rats
Added February 21, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.
Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI
(2012) Proc Natl Acad Sci U S A 109: E2343-52
MeSH Terms: Adult, Aged, Aged, 80 and over, Animals, Apoptosis, Apoptosis Regulatory Proteins, Bone Marrow Cells, Caspase 1, Caspase 9, Deoxyadenosines, Genetic Predisposition to Disease, Genetic Variation, HEK293 Cells, HapMap Project, Humans, Methionine, Mice, Mice, Inbred C57BL, Middle Aged, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Salmonella Infections, Salmonella typhimurium, Thionucleosides, Young Adult
Added April 13, 2017
0 Communities
1 Members
0 Resources
25 MeSH Terms
Inflammasome-independent role of apoptosis-associated speck-like protein containing a CARD (ASC) in T cell priming is critical for collagen-induced arthritis.
Ippagunta SK, Brand DD, Luo J, Boyd KL, Calabrese C, Stienstra R, Van de Veerdonk FL, Netea MG, Joosten LA, Lamkanfi M, Kanneganti TD
(2010) J Biol Chem 285: 12454-62
MeSH Terms: Animals, Apoptosis Regulatory Proteins, Arthritis, Experimental, Autoantibodies, CARD Signaling Adaptor Proteins, Carrier Proteins, Caspase 1, Collagen, Cytoskeletal Proteins, Dendritic Cells, Humans, Lymphocyte Activation, Mice, Mice, Inbred C57BL, Mice, Knockout, NLR Family, Pyrin Domain-Containing 3 Protein, T-Lymphocytes
Added March 20, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1.
Thomas PG, Dash P, Aldridge JR, Ellebedy AH, Reynolds C, Funk AJ, Martin WJ, Lamkanfi M, Webby RJ, Boyd KL, Doherty PC, Kanneganti TD
(2009) Immunity 30: 566-75
MeSH Terms: Animals, Antigen-Presenting Cells, Carrier Proteins, Caspase 1, Cells, Cultured, Gene Expression Regulation, Genetic Predisposition to Disease, Immunity, Innate, Influenza A virus, Interleukin-1beta, Mice, Mice, Inbred C57BL, Mice, Knockout, NLR Family, Pyrin Domain-Containing 3 Protein
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival.
Lamkanfi M, Moreira LO, Makena P, Spierings DC, Boyd K, Murray PJ, Green DR, Kanneganti TD
(2009) Blood 113: 2742-5
MeSH Terms: Animals, Apoptosis, Caspase 1, Caspase 3, Caspase 7, Chemokines, Cytokines, Endotoxemia, Endotoxins, Enzyme Activation, Injections, Intraperitoneal, Lymphocytes, Mice, Mice, Inbred C57BL, Mice, Knockout, Specific Pathogen-Free Organisms, Spleen
Added March 5, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Helicobacter pylori infection upregulates interleukin-18 production from gastric epithelial cells.
Shimada M, Ando T, Peek RM, Watanabe O, Ishiguro K, Maeda O, Ishikawa D, Hasegawa M, Ina K, Ohmiya N, Niwa Y, Goto H
(2008) Eur J Gastroenterol Hepatol 20: 1144-50
MeSH Terms: Adult, Aged, Apoptosis, Caspase 1, Caspase 3, Cells, Cultured, Dyspepsia, Epithelial Cells, Fas Ligand Protein, Female, Gastric Mucosa, Helicobacter Infections, Helicobacter pylori, Humans, Interferon-gamma, Interleukin-18, Male, Middle Aged, Organ Culture Techniques, Stomach Ulcer, Up-Regulation
Added March 5, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Versatile prostate cancer treatment with inducible caspase and interleukin-12.
Nikitina EY, Desai SA, Zhao X, Song W, Luo AZ, Gangula RD, Slawin KM, Spencer DM
(2005) Cancer Res 65: 4309-19
MeSH Terms: Adenocarcinoma, Adenoviridae, Animals, Apoptosis, B7-1 Antigen, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cancer Vaccines, Caspase 1, Dendritic Cells, Interferon-gamma, Interleukin-12, Lymphocyte Activation, Male, Mice, Mice, Inbred C57BL, Prostatic Neoplasms, T-Lymphocytes, Cytotoxic
Added April 7, 2010
0 Communities
1 Members
0 Resources
18 MeSH Terms