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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 271

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N-[F]-Fluoroacetylcrizotinib: A potentially potent and selective PET tracer for molecular imaging of non-small cell lung cancer.
Buck JR, Saleh S, Claus T, Lovly C, Hight MR, Nickels ML, Noor Tantawy M, Charles Manning H
(2020) Bioorg Med Chem Lett 30: 127257
MeSH Terms: Anaplastic Lymphoma Kinase, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Cell Proliferation, Crizotinib, Dose-Response Relationship, Drug, Fluorine Radioisotopes, Humans, Lung Neoplasms, Molecular Imaging, Molecular Structure, Positron-Emission Tomography, Protein Kinase Inhibitors, Structure-Activity Relationship
Added September 10, 2020
0 Communities
1 Members
0 Resources
14 MeSH Terms
Vulnerability of drug-resistant EML4-ALK rearranged lung cancer to transcriptional inhibition.
Paliouras AR, Buzzetti M, Shi L, Donaldson IJ, Magee P, Sahoo S, Leong HS, Fassan M, Carter M, Di Leva G, Krebs MG, Blackhall F, Lovly CM, Garofalo M
(2020) EMBO Mol Med 12: e11099
MeSH Terms: Animals, Carcinoma, Non-Small-Cell Lung, Drug Resistance, Neoplasm, Female, Humans, Lung Neoplasms, Mice, Oncogene Proteins, Fusion, Protein Kinase Inhibitors, Transcription, Genetic
Added September 10, 2020
0 Communities
1 Members
0 Resources
10 MeSH Terms
Monitoring Therapeutic Response and Resistance: Analysis of Circulating Tumor DNA in Patients With ALK+ Lung Cancer.
Horn L, Whisenant JG, Wakelee H, Reckamp KL, Qiao H, Leal TA, Du L, Hernandez J, Huang V, Blumenschein GR, Waqar SN, Patel SP, Nieva J, Oxnard GR, Sanborn RE, Shaffer T, Garg K, Holzhausen A, Harrow K, Liang C, Lim LP, Li M, Lovly CM
(2019) J Thorac Oncol 14: 1901-1911
MeSH Terms: Adult, Aged, Aged, 80 and over, Anaplastic Lymphoma Kinase, Carcinoma, Non-Small-Cell Lung, Circulating Tumor DNA, Drug Resistance, Neoplasm, Female, Humans, Lung Neoplasms, Male, Middle Aged, Mutation, Oncogene Proteins, Fusion, Piperazines, Prognosis, Protein Kinase Inhibitors, Pyridazines
Added March 18, 2020
0 Communities
1 Members
0 Resources
18 MeSH Terms
On-target Resistance to the Mutant-Selective EGFR Inhibitor Osimertinib Can Develop in an Allele-Specific Manner Dependent on the Original EGFR-Activating Mutation.
Brown BP, Zhang YK, Westover D, Yan Y, Qiao H, Huang V, Du Z, Smith JA, Ross JS, Miller VA, Ali S, Bazhenova L, Schrock AB, Meiler J, Lovly CM
(2019) Clin Cancer Res 25: 3341-3351
MeSH Terms: Acrylamides, Alleles, Aniline Compounds, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Dose-Response Relationship, Drug, Drug Resistance, Neoplasm, ErbB Receptors, Exons, Gene Expression Profiling, Humans, Lung Neoplasms, Models, Molecular, Mutation, Protein Binding, Protein Kinase Inhibitors, Structure-Activity Relationship
Added March 21, 2020
0 Communities
2 Members
0 Resources
17 MeSH Terms
Variable Response to ALK Inhibitors in NSCLC with a Novel MYT1L-ALK Fusion.
Tsou TC, Gowen K, Ali SM, Miller VA, Schrock AB, Lovly CM, Reckamp KL
(2019) J Thorac Oncol 14: e29-e30
MeSH Terms: Carcinoma, Non-Small-Cell Lung, Humans, Lung Neoplasms, Nerve Tissue Proteins, Protein Kinase Inhibitors, Receptor Protein-Tyrosine Kinases, Transcription Factors
Added September 10, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Sequencing Therapy for Genetically Defined Subgroups of Non-Small Cell Lung Cancer.
Yu HA, Planchard D, Lovly CM
(2018) Am Soc Clin Oncol Educ Book 38: 726-739
MeSH Terms: Carcinoma, Non-Small-Cell Lung, Humans, Lung Neoplasms
Added September 10, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production.
Sausville LN, Gangadhariah MH, Chiusa M, Mei S, Wei S, Zent R, Luther JM, Shuey MM, Capdevila JH, Falck JR, Guengerich FP, Williams SM, Pozzi A
(2018) Cancer Res 78: 4865-4877
MeSH Terms: Animals, Arachidonic Acid, Arachidonic Acids, Carcinogenesis, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Cytochrome P-450 CYP2C9, Cytochrome P-450 Enzyme System, Eicosanoids, Endothelial Cells, Humans, Mice, Polymorphism, Single Nucleotide, Xenograft Model Antitumor Assays
Added October 25, 2018
0 Communities
2 Members
0 Resources
14 MeSH Terms
xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression.
Ji X, Qian J, Rahman SMJ, Siska PJ, Zou Y, Harris BK, Hoeksema MD, Trenary IA, Heidi C, Eisenberg R, Rathmell JC, Young JD, Massion PP
(2018) Oncogene 37: 5007-5019
MeSH Terms: 3T3 Cells, A549 Cells, Amino Acid Transport System y+, Animals, Carcinoma, Non-Small-Cell Lung, Cell Line, Cell Line, Tumor, Cell Proliferation, Cell Survival, Cystine, Cytoplasm, Disease Progression, Female, Glutamine, Humans, Lung Neoplasms, Male, Mice, Middle Aged
Added March 28, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Ensartinib (X-396) in ALK-Positive Non-Small Cell Lung Cancer: Results from a First-in-Human Phase I/II, Multicenter Study.
Horn L, Infante JR, Reckamp KL, Blumenschein GR, Leal TA, Waqar SN, Gitlitz BJ, Sanborn RE, Whisenant JG, Du L, Neal JW, Gockerman JP, Dukart G, Harrow K, Liang C, Gibbons JJ, Holzhausen A, Lovly CM, Wakelee HA
(2018) Clin Cancer Res 24: 2771-2779
MeSH Terms: Adult, Aged, Aged, 80 and over, Anaplastic Lymphoma Kinase, Animals, Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Disease Models, Animal, Dose-Response Relationship, Drug, Female, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Kaplan-Meier Estimate, Lung Neoplasms, Male, Mice, Middle Aged, Mutation, Neoplasm Grading, Neoplasm Staging, Piperazines, Prognosis, Protein Kinase Inhibitors, Pyridazines, Rats, Treatment Outcome, Young Adult
Added September 10, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Impact of EML4-ALK Variant on Resistance Mechanisms and Clinical Outcomes in ALK-Positive Lung Cancer.
Lin JJ, Zhu VW, Yoda S, Yeap BY, Schrock AB, Dagogo-Jack I, Jessop NA, Jiang GY, Le LP, Gowen K, Stephens PJ, Ross JS, Ali SM, Miller VA, Johnson ML, Lovly CM, Hata AN, Gainor JF, Iafrate AJ, Shaw AT, Ou SI
(2018) J Clin Oncol 36: 1199-1206
MeSH Terms: Adult, Aged, Anaplastic Lymphoma Kinase, Carcinoma, Non-Small-Cell Lung, Crizotinib, Drug Resistance, Neoplasm, Female, Humans, Lung Neoplasms, Male, Middle Aged, Mutation, Oncogene Proteins, Fusion, Prognosis, Protein Kinase Inhibitors, Retrospective Studies, Treatment Outcome, Young Adult
Added September 10, 2020
0 Communities
1 Members
0 Resources
MeSH Terms