Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity.
Wang S, Raybuck A, Shiuan E, Cho SH, Wang Q, Brantley-Sieders DM, Edwards D, Allaman MM, Nathan J, Wilson KT, DeNardo D, Zhang S, Cook R, Boothby M, Chen J
(2020) JCI Insight 5
: MeSH Terms: Animals, Antineoplastic Agents, Breast Neoplasms, Carcinoma, Lewis Lung, Disease Models, Animal, Endothelium, Vascular, Everolimus, Female, Humans, Lymphocytes, Tumor-Infiltrating, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Inbred C57BL, Signal TransductionAdded September 17, 2020
14 MeSH Terms
Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment.
Zaynagetdinov R, Sherrill TP, Gleaves LA, McLoed AG, Saxon JA, Habermann AC, Connelly L, Dulek D, Peebles RS, Fingleton B, Yull FE, Stathopoulos GT, Blackwell TS
(2015) Cancer Res 75
: 1624-1634MeSH Terms: Animals, Carcinoma, Lewis Lung, Cell Line, Tumor, Eosinophils, Female, Interleukin-5, Lung, Lung Neoplasms, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, T-Lymphocytes, Regulatory, Tumor Escape, Tumor MicroenvironmentAdded February 19, 2015
15 MeSH Terms
Role of TGF-β signaling in generation of CD39+CD73+ myeloid cells in tumors.
Ryzhov SV, Pickup MW, Chytil A, Gorska AE, Zhang Q, Owens P, Feoktistov I, Moses HL, Novitskiy SV
(2014) J Immunol 193
: 3155-64MeSH Terms: 5'-Nucleotidase, Animals, Antigens, CD, Apyrase, Bone Marrow Cells, Carcinoma, Lewis Lung, Cell Differentiation, Cell Line, Tumor, Cell Movement, Female, Mammary Glands, Animal, Mammary Neoplasms, Animal, Mice, Mice, Inbred C57BL, Mice, Knockout, Myeloid Cells, Protein Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, T-Lymphocytes, Transforming Growth Factor beta, Tumor Microenvironment, Vascular Endothelial Growth Factor AAdded December 3, 2014
24 MeSH Terms
Sequential targeted delivery of paclitaxel and camptothecin using a cross-linked "nanosponge" network for lung cancer chemotherapy.
Hariri G, Edwards AD, Merrill TB, Greenbaum JM, van der Ende AE, Harth E
(2014) Mol Pharm 11
: 265-75MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Camptothecin, Carcinoma, Lewis Lung, Cell Cycle, Cell Proliferation, Cross-Linking Reagents, Drug Carriers, Drug Delivery Systems, Humans, Immunoenzyme Techniques, Lung Neoplasms, Male, Mice, Mice, Inbred C57BL, Mice, Nude, Microscopy, Electron, Transmission, Nanoparticles, Paclitaxel, Peptide Fragments, Radiation, Ionizing, Tumor Cells, CulturedAdded July 21, 2014
23 MeSH Terms
Membrane versus soluble isoforms of TNF-α exert opposing effects on tumor growth and survival of tumor-associated myeloid cells.
Ardestani S, Li B, Deskins DL, Wu H, Massion PP, Young PP
(2013) Cancer Res 73
: 3938-50MeSH Terms: Animals, CD11b Antigen, Carcinoma, Lewis Lung, Carcinoma, Non-Small-Cell Lung, Cell Death, Cell Line, Tumor, Cell Movement, Cell Survival, Gene Expression, Humans, Lung Neoplasms, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Myeloid Cells, Neoplasm Transplantation, Protein Isoforms, Reactive Oxygen Species, Solubility, Tissue Array Analysis, Tumor Necrosis Factor-alphaAdded March 7, 2014
22 MeSH Terms
Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells.
Ryzhov S, Novitskiy SV, Goldstein AE, Biktasova A, Blackburn MR, Biaggioni I, Dikov MM, Feoktistov I
(2011) J Immunol 187
: 6120-9MeSH Terms: 5'-Nucleotidase, Adenosine, Animals, CD11b Antigen, Carcinoma, Lewis Lung, Cell Differentiation, Cell Proliferation, Cell Separation, Female, Flow Cytometry, Granulocytes, Male, Mice, Mice, Inbred C57BL, Myeloid Cells, Real-Time Polymerase Chain Reaction, Receptors, Purinergic P1Added May 29, 2014
17 MeSH Terms
Cytosolic phospholipase A2 and lysophospholipids in tumor angiogenesis.
Linkous AG, Yazlovitskaya EM, Hallahan DE
(2010) J Natl Cancer Inst 102
: 1398-412MeSH Terms: Animals, Carcinoma, Lewis Lung, Cell Movement, Cell Proliferation, Collagen, Disease Models, Animal, Drug Combinations, Endothelial Cells, Glioblastoma, Group IV Phospholipases A2, Laminin, Lysophospholipids, Mice, Necrosis, Neoplasm Invasiveness, Neoplasms, Neovascularization, Pathologic, Pericytes, Proteoglycans, Pulmonary CirculationAdded November 16, 2017
20 MeSH Terms
Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion.
Stathopoulos GT, Sherrill TP, Karabela SP, Goleniewska K, Kalomenidis I, Roussos C, Fingleton B, Yull FE, Peebles RS, Blackwell TS
(2010) Am J Respir Crit Care Med 182
: 1273-81MeSH Terms: Adenocarcinoma, Animals, Carcinoma, Lewis Lung, Cell Line, Tumor, Dose-Response Relationship, Drug, Eosinophils, Flow Cytometry, Gene Expression Profiling, Humans, Interleukin-5, Lung Neoplasms, Mice, Mice, Inbred C57BL, Pleural Effusion, MalignantAdded February 26, 2013
14 MeSH Terms
Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity.
Nyström A, Shaik ZP, Gullberg D, Krieg T, Eckes B, Zent R, Pozzi A, Iozzo RV
(2009) Blood 114
: 4897-906MeSH Terms: Animals, Carcinoma, Lewis Lung, Cell Adhesion, Endothelium, Vascular, Heparan Sulfate Proteoglycans, Humans, Integrin alpha1, Integrin alpha2beta1, Mice, Mice, Inbred C57BL, Mice, Knockout, Neovascularization, Pathologic, Neovascularization, Physiologic, Peptide Fragments, Phosphorylation, Phosphotyrosine, Protein Interaction Mapping, Protein Processing, Post-Translational, Protein Structure, Tertiary, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Receptor Protein-Tyrosine Kinases, Recombinant Fusion Proteins, Xenograft Model Antitumor AssaysAdded February 24, 2014
23 MeSH Terms
Host deficiency in Vav2/3 guanine nucleotide exchange factors impairs tumor growth, survival, and angiogenesis in vivo.
Brantley-Sieders DM, Zhuang G, Vaught D, Freeman T, Hwang Y, Hicks D, Chen J
(2009) Mol Cancer Res 7
: 615-23MeSH Terms: Animals, Carcinoma, Lewis Lung, Cell Line, Tumor, Cell Movement, Cell Proliferation, Cell Survival, Coculture Techniques, Endothelial Cells, Melanoma, Experimental, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Nude, Neoplasms, Experimental, Neovascularization, Pathologic, Proto-Oncogene Proteins c-vav, Transplantation, Homologous, Tumor Burden, von Willebrand FactorAdded May 23, 2013
19 MeSH Terms