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Results: 1 to 10 of 38

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Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors.
Bedse G, Bluett RJ, Patrick TA, Romness NK, Gaulden AD, Kingsley PJ, Plath N, Marnett LJ, Patel S
(2018) Transl Psychiatry 8: 92
MeSH Terms: Amidohydrolases, Animals, Anti-Anxiety Agents, Anxiety Disorders, Behavior, Animal, Benzodioxoles, Body Temperature, Brain, Carbamates, Endocannabinoids, Female, Locomotion, Male, Maze Learning, Mice, Inbred C57BL, Mice, Inbred ICR, Monoacylglycerol Lipases, Piperazines, Piperidines, Pyridines, Stress, Psychological
Added April 12, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site.
Goodman MC, Xu S, Rouzer CA, Banerjee S, Ghebreselasie K, Migliore M, Piomelli D, Marnett LJ
(2018) J Biol Chem 293: 3028-3038
MeSH Terms: Amidohydrolases, Catalytic Domain, Cyclooxygenase Inhibitors, Isoenzymes, Phenylcarbamates, Phenylpropionates, Prostaglandin-Endoperoxide Synthases, Protein Binding, Stereoisomerism, Substrate Specificity
Added April 22, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus.
Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, Gerzanich V, Medzhitov R, Simard JM, Kahle KT
(2017) Nat Med 23: 997-1003
MeSH Terms: Acetazolamide, Animals, Antioxidants, Blotting, Western, Bumetanide, Cerebral Hemorrhage, Cerebral Ventricles, Cerebrospinal Fluid, Choroid Plexus, Diuretics, Gene Knockdown Techniques, Gene Knockout Techniques, Hydrocephalus, Immunoblotting, Immunohistochemistry, Immunoprecipitation, Inflammation, NF-kappa B, Proline, Protein-Serine-Threonine Kinases, Rats, Rats, Wistar, Salicylanilides, Solute Carrier Family 12, Member 2, Sulfonamides, Thiocarbamates, Toll-Like Receptor 4
Added April 3, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Ubiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling.
Coffey RT, Shi Y, Long MJ, Marr MT, Hedstrom L
(2016) J Biol Chem 291: 5221-33
MeSH Terms: Adaptor Proteins, Signal Transducing, Arginine, Carbamates, Cell Cycle Proteins, Cell Line, Tumor, Cell Proliferation, Enzyme Inhibitors, HEK293 Cells, Humans, Mechanistic Target of Rapamycin Complex 1, Multiprotein Complexes, Phosphoproteins, Phosphorylation, Protein Binding, Protein Biosynthesis, Protein Processing, Post-Translational, Ribosomal Protein S6 Kinases, Signal Transduction, TOR Serine-Threonine Kinases, Ubiquitins
Added May 9, 2016
0 Communities
1 Members
0 Resources
20 MeSH Terms
Structural basis for rational design of inhibitors targeting Trypanosoma cruzi sterol 14α-demethylase: two regions of the enzyme molecule potentiate its inhibition.
Friggeri L, Hargrove TY, Rachakonda G, Williams AD, Wawrzak Z, Di Santo R, De Vita D, Waterman MR, Tortorella S, Villalta F, Lepesheva GI
(2014) J Med Chem 57: 6704-17
MeSH Terms: 14-alpha Demethylase Inhibitors, Carbamates, Crystallography, X-Ray, Drug Design, Imidazoles, Models, Molecular, Protein Binding, Protein Conformation, Stereoisomerism, Sterol 14-Demethylase, Trypanocidal Agents, Trypanosoma cruzi
Added February 12, 2015
0 Communities
2 Members
0 Resources
12 MeSH Terms
Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1α.
Jiang JY, Nagaraju M, Meyer RC, Zhang L, Hamelberg D, Hall RA, Brown EM, Conn PJ, Yang JJ
(2014) J Biol Chem 289: 1649-61
MeSH Terms: Allosteric Regulation, Amino Acid Substitution, Benzoates, Binding Sites, Calcium, Calcium Signaling, Carbamates, Excitatory Amino Acid Agonists, Glycine, HEK293 Cells, Humans, Mutation, Missense, Protein Structure, Tertiary, Quisqualic Acid, Receptors, Metabotropic Glutamate, Xanthenes
Added February 19, 2015
0 Communities
1 Members
0 Resources
16 MeSH Terms
Dopaminergic neurotoxicity of S-ethyl N,N-dipropylthiocarbamate (EPTC), molinate, and S-methyl-N,N-diethylthiocarbamate (MeDETC) in Caenorhabditis elegans.
Caito SW, Valentine WM, Aschner M
(2013) J Neurochem 127: 837-51
MeSH Terms: Animals, Azepines, Caenorhabditis elegans, Cholinergic Neurons, Dopamine, Dopaminergic Neurons, Environmental Pollutants, Glutamic Acid, Herbicides, Lethal Dose 50, Oxidative Stress, Thiocarbamates, gamma-Aminobutyric Acid
Added May 27, 2014
1 Communities
1 Members
0 Resources
13 MeSH Terms
Spatial analysis of human lens aquaporin-0 post-translational modifications by MALDI mass spectrometry tissue profiling.
Gutierrez DB, Garland D, Schey KL
(2011) Exp Eye Res 93: 912-20
MeSH Terms: Acetylation, Adult, Age Factors, Aged, Aging, Aquaporins, Carbamates, Child, Chromatography, Liquid, Eye Proteins, Humans, Lens, Crystalline, Oleic Acids, Protein Processing, Post-Translational, Proteomics, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Tandem Mass Spectrometry, Young Adult
Added May 27, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Preclinical efficacy of a carboxylesterase 2-activated prodrug of doxazolidine.
Barthel BL, Zhang Z, Rudnicki DL, Coldren CD, Polinkovsky M, Sun H, Koch GG, Chan DC, Koch TH
(2009) J Med Chem 52: 7678-88
MeSH Terms: Animals, Antineoplastic Agents, Blotting, Western, Carbamates, Carboxylesterase, Cell Line, Tumor, Cell Proliferation, Doxorubicin, Drug Evaluation, Preclinical, Female, Gene Expression Regulation, Enzymologic, Humans, Mice, Myocytes, Cardiac, Neoplasms, Oxazoles, Prodrugs, Rats, Regression Analysis
Added November 17, 2011
0 Communities
1 Members
0 Resources
19 MeSH Terms
Room-temperature Pd-catalyzed amidation of aryl bromides using tert-butyl carbamate.
Bhagwanth S, Waterson AG, Adjabeng GM, Hornberger KR
(2009) J Org Chem 74: 4634-7
MeSH Terms: Aniline Compounds, Bromobenzenes, Carbamates, Catalysis, Organometallic Compounds, Palladium, Temperature
Added March 5, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms