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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 51

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Cell-free hemoglobin increases inflammation, lung apoptosis, and microvascular permeability in murine polymicrobial sepsis.
Meegan JE, Shaver CM, Putz ND, Jesse JJ, Landstreet SR, Lee HNR, Sidorova TN, McNeil JB, Wynn JL, Cheung-Flynn J, Komalavilas P, Brophy CM, Ware LB, Bastarache JA
(2020) PLoS One 15: e0228727
MeSH Terms: Animals, Apoptosis, Capillary Permeability, Endothelial Cells, Female, Hemoglobins, Humans, Inflammation, Lung, Mice, Mice, Inbred C57BL, Oxidative Stress, Sepsis
Added March 3, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
Toll-like receptor 3-mediated inflammation by p38 is enhanced by endothelial nitric oxide synthase knockdown.
Koch SR, Choi H, Mace EH, Stark RJ
(2019) Cell Commun Signal 17: 33
MeSH Terms: Capillary Permeability, Cells, Cultured, Chemokine CXCL10, Endothelium, Vascular, Gene Knockdown Techniques, Humans, Inflammation, Interleukin-6, Interleukin-8, Nitric Oxide Synthase Type III, Poly I-C, RNA, Small Interfering, Toll-Like Receptor 3, p38 Mitogen-Activated Protein Kinases
Added April 17, 2019
0 Communities
1 Members
0 Resources
14 MeSH Terms
Rapid changes in the microvascular circulation of skeletal muscle impair insulin delivery during sepsis.
Mignemi NA, McClatchey PM, Kilchrist KV, Williams IM, Millis BA, Syring KE, Duvall CL, Wasserman DH, McGuinness OP
(2019) Am J Physiol Endocrinol Metab 316: E1012-E1023
MeSH Terms: Animals, Capillaries, Capillary Permeability, Disease Models, Animal, Echocardiography, Hyperglycemia, Insulin, Insulin Resistance, Lipopolysaccharides, Mice, Microcirculation, Microvessels, Muscle Fibers, Skeletal, Muscle, Skeletal, Sepsis
Added March 26, 2019
1 Communities
1 Members
0 Resources
15 MeSH Terms
Matrix stiffness regulates vascular integrity through focal adhesion kinase activity.
Wang W, Lollis EM, Bordeleau F, Reinhart-King CA
(2019) FASEB J 33: 1199-1208
MeSH Terms: Adherens Junctions, Animals, Antigens, CD, Cadherins, Capillary Permeability, Chick Embryo, Endothelium, Vascular, Enzyme Activation, Extracellular Matrix, Female, Focal Adhesion Protein-Tyrosine Kinases, Human Umbilical Vein Endothelial Cells, Humans, Mice, Mice, Transgenic, Phosphorylation, Protein Transport, Tyrosine, src-Family Kinases
Added April 10, 2019
0 Communities
1 Members
0 Resources
19 MeSH Terms
Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury.
Haeger SM, Liu X, Han X, McNeil JB, Oshima K, McMurtry SA, Yang Y, Ouyang Y, Zhang F, Nozik-Grayck E, Zemans RL, Tuder RM, Bastarache JA, Linhardt RJ, Schmidt EP
(2018) Am J Respir Cell Mol Biol 59: 363-374
MeSH Terms: Animals, Capillary Permeability, Endothelium, Vascular, Glycocalyx, Heparitin Sulfate, Lipopolysaccharides, Lung Injury, Mice, Respiratory Distress Syndrome, Syndecans
Added May 31, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury.
Shaver CM, Wickersham N, McNeil JB, Nagata H, Miller A, Landstreet SR, Kuck JL, Diamond JM, Lederer DJ, Kawut SM, Palmer SM, Wille KM, Weinacker A, Lama VN, Crespo MM, Orens JB, Shah PD, Hage CA, Cantu E, Porteous MK, Dhillon G, McDyer J, Bastarache JA, Christie JD, Ware LB, Lung Transplant Outcomes Group (LTOG)
(2018) JCI Insight 3:
MeSH Terms: Acetaminophen, Allografts, Capillary Permeability, Case-Control Studies, Cell Line, Endothelial Cells, Female, Hemoglobins, Humans, Hyperoxia, Lung, Lung Transplantation, Male, Microvessels, Middle Aged, Oxidative Stress, Primary Graft Dysfunction
Added May 31, 2018
0 Communities
1 Members
0 Resources
17 MeSH Terms
Ascorbic acid attenuates endothelial permeability triggered by cell-free hemoglobin.
Kuck JL, Bastarache JA, Shaver CM, Fessel JP, Dikalov SI, May JM, Ware LB
(2018) Biochem Biophys Res Commun 495: 433-437
MeSH Terms: Antioxidants, Ascorbic Acid, Capillary Permeability, Endothelium, Vascular, Hemoglobins, Human Umbilical Vein Endothelial Cells, Humans, Sepsis
Added March 14, 2018
0 Communities
3 Members
0 Resources
8 MeSH Terms
Endothelial nitric oxide synthase modulates Toll-like receptor 4-mediated IL-6 production and permeability via nitric oxide-independent signaling.
Stark RJ, Koch SR, Choi H, Mace EH, Dikalov SI, Sherwood ER, Lamb FS
(2018) FASEB J 32: 945-956
MeSH Terms: Capillary Permeability, Cells, Cultured, Chronic Disease, Endothelial Cells, Gene Expression Regulation, Enzymologic, Humans, Imidazoles, Interleukin-6, Lipopolysaccharides, MAP Kinase Signaling System, Nitric Oxide, Nitric Oxide Synthase Type III, Pyridines, Toll-Like Receptor 4, Vasculitis, p38 Mitogen-Activated Protein Kinases
Added October 27, 2017
0 Communities
3 Members
0 Resources
16 MeSH Terms
Cell-Free Hemoglobin-mediated Increases in Vascular Permeability. A Novel Mechanism of Primary Graft Dysfunction and a New Therapeutic Target.
Shaver CM, Wickersham N, McNeil JB, Nagata H, Sills G, Kuck JL, Janz DR, Bastarache JA, Ware LB
(2017) Ann Am Thorac Soc 14: S251-S252
MeSH Terms: Acetaminophen, Capillary Permeability, Endothelial Cells, Hemoglobins, Humans, Lung, Lung Transplantation, Primary Graft Dysfunction
Added May 31, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
High efficacy vasopermeability drug candidates identified by screening in an ex ovo chorioallantoic membrane model.
Pink D, Luhrs KA, Zhou L, Schulte W, Chase J, Frosch C, Haberl U, Nguyen V, Roy AI, Lewis JD, Zijlstra A, Parseghian MH
(2015) Sci Rep 5: 15756
MeSH Terms: Animals, Antineoplastic Agents, Capillary Permeability, Cell Line, Tumor, Chick Embryo, Chorioallantoic Membrane, Drug Screening Assays, Antitumor, Humans, Mice
Added April 6, 2017
1 Communities
1 Members
0 Resources
9 MeSH Terms