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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 9 of 9

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RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT.
Kryshtal DO, Blackwell DJ, Egly CL, Smith AN, Batiste SM, Johnston JN, Laver DR, Knollmann BC
(2021) Circ Res 128: 321-331
MeSH Terms: Action Potentials, Animals, Anti-Arrhythmia Agents, Calcium Channel Blockers, Calcium Signaling, Calsequestrin, Disease Models, Animal, Female, Flecainide, HEK293 Cells, Heart Rate, Humans, Male, Mice, Knockout, Myocytes, Cardiac, Phosphorylation, Ryanodine Receptor Calcium Release Channel, Sarcoplasmic Reticulum, Sheep, Domestic, Tachycardia, Ventricular, Voltage-Gated Sodium Channel Blockers
Added December 21, 2020
1 Communities
0 Members
0 Resources
21 MeSH Terms
Channel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes.
Savio-Galimberti E, Knollmann BC
(2015) PLoS One 10: e0131179
MeSH Terms: Animals, Arrhythmias, Cardiac, Caffeine, Calcium, Calcium Signaling, Calsequestrin, Cell Membrane Permeability, Flecainide, Heart Ventricles, Humans, Inhibitory Concentration 50, Male, Mice, Inbred C57BL, Myocytes, Cardiac, Propafenone, Rabbits, Ryanodine Receptor Calcium Release Channel, Tetracaine
Added February 22, 2016
0 Communities
1 Members
0 Resources
18 MeSH Terms
Alternating membrane potential/calcium interplay underlies repetitive focal activity in a genetic model of calcium-dependent atrial arrhythmias.
Lou Q, Belevych AE, Radwański PB, Liu B, Kalyanasundaram A, Knollmann BC, Fedorov VV, Györke S
(2015) J Physiol 593: 1443-58
MeSH Terms: Action Potentials, Animals, Atrial Fibrillation, Calcium Signaling, Calsequestrin, Cells, Cultured, Heart Atria, Membrane Potentials, Mice, Myocytes, Cardiac, Periodicity
Added February 12, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
Suppression of spontaneous ca elevations prevents atrial fibrillation in calsequestrin 2-null hearts.
Faggioni M, Savio-Galimberti E, Venkataraman R, Hwang HS, Kannankeril PJ, Darbar D, Knollmann BC
(2014) Circ Arrhythm Electrophysiol 7: 313-20
MeSH Terms: Animals, Atrial Fibrillation, Calcium, Calsequestrin, Cardiac Pacing, Artificial, Disease Models, Animal, Mice, Mice, Knockout, Muscle Cells, Propafenone, Treatment Outcome, Voltage-Gated Sodium Channel Blockers
Added May 29, 2014
0 Communities
2 Members
0 Resources
12 MeSH Terms
Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex1.
Glukhov AV, Kalyanasundaram A, Lou Q, Hage LT, Hansen BJ, Belevych AE, Mohler PJ, Knollmann BC, Periasamy M, Györke S, Fedorov VV
(2015) Eur Heart J 36: 686-97
MeSH Terms: Action Potentials, Animals, Atrial Fibrillation, Atrial Function, Bradycardia, Calcium, Calsequestrin, Cardiomegaly, Fibrosis, Gene Deletion, Gene Knockout Techniques, Mice, Transgenic, Sarcoplasmic Reticulum, Sinoatrial Node
Added February 12, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
Triadin regulates cardiac muscle couplon structure and microdomain Ca(2+) signalling: a path towards ventricular arrhythmias.
Chopra N, Knollmann BC
(2013) Cardiovasc Res 98: 187-91
MeSH Terms: Animals, Calcium Channels, L-Type, Calcium Signaling, Calsequestrin, Carrier Proteins, Excitation Contraction Coupling, Humans, Membrane Microdomains, Muscle Proteins, Myocytes, Cardiac, Ryanodine Receptor Calcium Release Channel, Sarcoplasmic Reticulum, Tachycardia, Ventricular
Added February 12, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
Efficacy and potency of class I antiarrhythmic drugs for suppression of Ca2+ waves in permeabilized myocytes lacking calsequestrin.
Galimberti ES, Knollmann BC
(2011) J Mol Cell Cardiol 51: 760-8
MeSH Terms: Animals, Anti-Arrhythmia Agents, Calcium, Calcium Signaling, Calsequestrin, Cell Membrane Permeability, Cells, Cultured, Disease, Dose-Response Relationship, Drug, Flecainide, Humans, Inhibitory Concentration 50, Mice, Mice, Knockout, Microscopy, Confocal, Molecular Imaging, Myocytes, Cardiac, Propafenone, Saponins, Stereoisomerism, Tachycardia, Ventricular
Added July 21, 2014
1 Communities
0 Members
0 Resources
21 MeSH Terms
Phosphorylation-status of phospholamban and calsequestrin modifies their affinity towards commonly used antibodies.
Huke S, Periasamy M
(2004) J Mol Cell Cardiol 37: 795-9
MeSH Terms: Animals, Antibodies, Antibody Affinity, Binding Sites, Antibody, Blotting, Western, Calcium-Binding Proteins, Calsequestrin, Mice, Myocardium, Phosphorylation, Sarcoplasmic Reticulum
Added May 27, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Functional properties of transgenic mouse hearts overexpressing both calsequestrin and the Na(+)-Ca(2+) exchanger.
Linck B, Bokník P, Huke S, Kirchhefer U, Knapp J, Lüss H, Müller FU, Neumann J, Tanriseven Z, Vahlensieck U, Baba HA, Jones LR, Philipson KD, Schmitz W
(2000) J Pharmacol Exp Ther 294: 648-57
MeSH Terms: Animals, Body Weight, Caffeine, Calcium, Calcium Channels, L-Type, Calcium-Transporting ATPases, Calsequestrin, Cardiomegaly, Cytosol, Female, Gene Expression, Heart, Heart Rate, In Vitro Techniques, Male, Mice, Mice, Transgenic, Myocardial Contraction, Myocardium, Organ Size, RNA, Messenger, Sarcoplasmic Reticulum, Sodium-Calcium Exchanger
Added May 27, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms