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Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males.
Walker EM, Cha J, Tong X, Guo M, Liu JH, Yu S, Iacovazzo D, Mauvais-Jarvis F, Flanagan SE, Korbonits M, Stafford J, Jacobson DA, Stein R
(2021) Cell Rep 37: 109813
MeSH Terms: Animals, Animals, Genetically Modified, Blood Glucose, Calcium Signaling, Cell Line, Cellular Senescence, DNA Damage, Diabetes Mellitus, Type 2, Disease Models, Animal, Female, Genetic Predisposition to Disease, Humans, Insulin, Insulin-Secreting Cells, Maf Transcription Factors, Large, Male, Mice, Inbred C57BL, Mutation, Missense, Phenotype, Sex Characteristics, Sex Factors
Added November 23, 2021
0 Communities
1 Members
0 Resources
21 MeSH Terms
A KCNK16 mutation causing TALK-1 gain of function is associated with maturity-onset diabetes of the young.
Graff SM, Johnson SR, Leo PJ, Dadi PK, Dickerson MT, Nakhe AY, McInerney-Leo AM, Marshall M, Zaborska KE, Schaub CM, Brown MA, Jacobson DA, Duncan EL
(2021) JCI Insight 6:
MeSH Terms: Animals, Blood Glucose, Calcium Signaling, Channelopathies, Diabetes Mellitus, Type 2, Gain of Function Mutation, Humans, Insulin Secretion, Insulin-Secreting Cells, Membrane Potentials, Mice, Potassium Channels, Tandem Pore Domain
Added June 14, 2021
0 Communities
1 Members
0 Resources
12 MeSH Terms
RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission.
Shumate KM, Tas ST, Kavalali ET, Emeson RB
(2021) J Neurochem 158: 182-196
MeSH Terms: Adenosine Deaminase, Animals, CRISPR-Cas Systems, Calcium-Binding Proteins, Electrophysiological Phenomena, Glutamic Acid, High-Throughput Nucleotide Sequencing, Hippocampus, Mice, Mutation, Nerve Tissue Proteins, Neuronal Plasticity, Primary Cell Culture, RNA Editing, Synaptic Transmission, gamma-Aminobutyric Acid
Added April 30, 2021
1 Communities
0 Members
0 Resources
16 MeSH Terms
Statins and Atherosclerotic Lesion Microcalcification: A New Mechanism for Plaque Stability?
Doran AC, Terry JG, Carr JJ, Linton MF
(2021) Arterioscler Thromb Vasc Biol 41: 1306-1308
MeSH Terms: Animals, Atherosclerosis, Calcium, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Mice, Plaque, Atherosclerotic, Vascular Calcification
Added April 20, 2021
0 Communities
1 Members
0 Resources
7 MeSH Terms
RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT.
Kryshtal DO, Blackwell DJ, Egly CL, Smith AN, Batiste SM, Johnston JN, Laver DR, Knollmann BC
(2021) Circ Res 128: 321-331
MeSH Terms: Action Potentials, Animals, Anti-Arrhythmia Agents, Calcium Channel Blockers, Calcium Signaling, Calsequestrin, Disease Models, Animal, Female, Flecainide, HEK293 Cells, Heart Rate, Humans, Male, Mice, Knockout, Myocytes, Cardiac, Phosphorylation, Ryanodine Receptor Calcium Release Channel, Sarcoplasmic Reticulum, Sheep, Domestic, Tachycardia, Ventricular, Voltage-Gated Sodium Channel Blockers
Added December 21, 2020
1 Communities
0 Members
0 Resources
21 MeSH Terms
Molecular and functional profiling of human islets: from heterogeneity to human phenotypes.
Arrojo E Drigo R, Roy B, MacDonald PE
(2020) Diabetologia 63: 2095-2101
MeSH Terms: Calcium, Genotype, Humans, Insulin Secretion, Insulin-Secreting Cells, Islets of Langerhans, Phenotype, Single-Cell Analysis, Transcriptome
Added April 14, 2021
0 Communities
1 Members
0 Resources
9 MeSH Terms
Tetraspanin-7 regulation of L-type voltage-dependent calcium channels controls pancreatic β-cell insulin secretion.
Dickerson MT, Dadi PK, Butterworth RB, Nakhe AY, Graff SM, Zaborska KE, Schaub CM, Jacobson DA
(2020) J Physiol 598: 4887-4905
MeSH Terms: Animals, Calcium, Calcium Channels, L-Type, Glucagon-Secreting Cells, Glucose, Insulin, Insulin Secretion, Insulin-Secreting Cells, Mice
Added June 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Lactate activation of α-cell K channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca entry.
Zaborska KE, Dadi PK, Dickerson MT, Nakhe AY, Thorson AS, Schaub CM, Graff SM, Stanley JE, Kondapavuluru RS, Denton JS, Jacobson DA
(2020) Mol Metab 42: 101056
MeSH Terms: Animals, Calcium, Cell Line, Cell Membrane, Glucagon, Glucagon-Secreting Cells, Glucose, Humans, Islets of Langerhans, KATP Channels, Lactic Acid, Male, Membrane Potentials, Mice, Mice, Inbred C57BL, Mice, Transgenic, Pancreas, Primary Cell Culture, Pyruvic Acid
Added June 14, 2021
0 Communities
1 Members
0 Resources
19 MeSH Terms
Association of Chronic Kidney Disease Stage with 24-Hour Urine Values Among Patients with Nephrolithiasis.
Sui W, Calvert JK, Kavoussi NL, Gould ER, Miller NL, Bejan CA, Hsi RS
(2020) J Endourol 34: 1263-1271
MeSH Terms: Calcium Oxalate, Humans, Kidney Calculi, Nephrolithiasis, Oxalates, Renal Insufficiency, Chronic, Retrospective Studies
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Cost-effectiveness of Contemporary Statin Use Guidelines With or Without Coronary Artery Calcium Assessment in African American Individuals.
Spahillari A, Zhu J, Ferket BS, Hunink MGM, Carr JJ, Terry JG, Nelson C, Mwasongwe S, Mentz RJ, O'Brien EC, Correa A, Shah RV, Murthy VL, Pandya A
(2020) JAMA Cardiol 5: 871-880
MeSH Terms: African Americans, Aged, Calcium, Coronary Disease, Coronary Vessels, Cost-Benefit Analysis, Health Care Costs, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Middle Aged, Models, Economic, Practice Guidelines as Topic, Quality-Adjusted Life Years, Risk Factors, Vascular Calcification
Added July 20, 2020
0 Communities
1 Members
0 Resources
16 MeSH Terms