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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 110

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Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males.
Walker EM, Cha J, Tong X, Guo M, Liu JH, Yu S, Iacovazzo D, Mauvais-Jarvis F, Flanagan SE, Korbonits M, Stafford J, Jacobson DA, Stein R
(2021) Cell Rep 37: 109813
MeSH Terms: Animals, Animals, Genetically Modified, Blood Glucose, Calcium Signaling, Cell Line, Cellular Senescence, DNA Damage, Diabetes Mellitus, Type 2, Disease Models, Animal, Female, Genetic Predisposition to Disease, Humans, Insulin, Insulin-Secreting Cells, Maf Transcription Factors, Large, Male, Mice, Inbred C57BL, Mutation, Missense, Phenotype, Sex Characteristics, Sex Factors
Added November 23, 2021
0 Communities
1 Members
0 Resources
21 MeSH Terms
A KCNK16 mutation causing TALK-1 gain of function is associated with maturity-onset diabetes of the young.
Graff SM, Johnson SR, Leo PJ, Dadi PK, Dickerson MT, Nakhe AY, McInerney-Leo AM, Marshall M, Zaborska KE, Schaub CM, Brown MA, Jacobson DA, Duncan EL
(2021) JCI Insight 6:
MeSH Terms: Animals, Blood Glucose, Calcium Signaling, Channelopathies, Diabetes Mellitus, Type 2, Gain of Function Mutation, Humans, Insulin Secretion, Insulin-Secreting Cells, Membrane Potentials, Mice, Potassium Channels, Tandem Pore Domain
Added June 14, 2021
0 Communities
1 Members
0 Resources
12 MeSH Terms
RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT.
Kryshtal DO, Blackwell DJ, Egly CL, Smith AN, Batiste SM, Johnston JN, Laver DR, Knollmann BC
(2021) Circ Res 128: 321-331
MeSH Terms: Action Potentials, Animals, Anti-Arrhythmia Agents, Calcium Channel Blockers, Calcium Signaling, Calsequestrin, Disease Models, Animal, Female, Flecainide, HEK293 Cells, Heart Rate, Humans, Male, Mice, Knockout, Myocytes, Cardiac, Phosphorylation, Ryanodine Receptor Calcium Release Channel, Sarcoplasmic Reticulum, Sheep, Domestic, Tachycardia, Ventricular, Voltage-Gated Sodium Channel Blockers
Added December 21, 2020
1 Communities
0 Members
0 Resources
21 MeSH Terms
Calmodulin Mutations Associated with Heart Arrhythmia: A Status Report.
Chazin WJ, Johnson CN
(2020) Int J Mol Sci 21:
MeSH Terms: Arrhythmias, Cardiac, Calcium Signaling, Calmodulin, Humans, Ion Channels, Long QT Syndrome, Myocytes, Cardiac, Ryanodine Receptor Calcium Release Channel, Tachycardia, Ventricular
Added March 11, 2020
0 Communities
1 Members
0 Resources
9 MeSH Terms
Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist.
Azumaya CM, Linton EA, Risener CJ, Nakagawa T, Karakas E
(2020) J Biol Chem 295: 1743-1753
MeSH Terms: Binding Sites, Calcium Signaling, Cryoelectron Microscopy, Humans, Inositol 1,4,5-Trisphosphate, Inositol 1,4,5-Trisphosphate Receptors, Models, Molecular, Peptides, Protein Conformation
Added March 3, 2020
0 Communities
2 Members
0 Resources
9 MeSH Terms
Small Molecule Inhibitor Screen Reveals Calcium Channel Signaling as a Mechanistic Mediator of TcdB-Induced Necrosis.
Farrow MA, Chumber NM, Bloch SC, King M, Moton-Melancon K, Shupe J, Washington MK, Spiller BW, Lacy DB
(2020) ACS Chem Biol 15: 1212-1221
MeSH Terms: Actin Cytoskeleton, Animals, Anti-Infective Agents, Bacterial Toxins, Calcium Channel Blockers, Calcium Channels, Calcium Signaling, Clostridioides difficile, Cytokines, Dihydropyridines, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Glucosyltransferases, Humans, Kinetics, Mice, NADPH Oxidases, Necrosis, Reactive Oxygen Species, Virulence Factors
Added March 24, 2020
0 Communities
2 Members
0 Resources
20 MeSH Terms
Ion Channels of the Islets in Type 2 Diabetes.
Jacobson DA, Shyng SL
(2020) J Mol Biol 432: 1326-1346
MeSH Terms: Animals, Calcium, Calcium Channels, Calcium Signaling, Diabetes Mellitus, Type 2, Glucose, Humans, Hyperglycemia, Insulin, Insulin Secretion, Insulin-Secreting Cells, Islets of Langerhans
Added June 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Interplay between ER Ca Binding Proteins, STIM1 and STIM2, Is Required for Store-Operated Ca Entry.
Nelson HA, Leech CA, Kopp RF, Roe MW
(2018) Int J Mol Sci 19:
MeSH Terms: 3T3 Cells, Animals, Calcium, Calcium Signaling, Fluorescence Resonance Energy Transfer, Green Fluorescent Proteins, Humans, Membrane Microdomains, Mice, Neoplasm Proteins, ORAI1 Protein, Protein Binding, Stromal Interaction Molecule 1, Stromal Interaction Molecule 2
Added July 6, 2018
0 Communities
1 Members
0 Resources
14 MeSH Terms
TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion.
Vierra NC, Dickerson MT, Jordan KL, Dadi PK, Katdare KA, Altman MK, Milian SC, Jacobson DA
(2018) Mol Metab 9: 84-97
MeSH Terms: Animals, Calcium Signaling, Cells, Cultured, Cytoplasm, Endoplasmic Reticulum, Glucagon, Humans, Male, Mice, Mice, Inbred C57BL, Potassium Channels, Tandem Pore Domain, Somatostatin, Somatostatin-Secreting Cells
Added February 7, 2018
0 Communities
1 Members
0 Resources
13 MeSH Terms
Molecular physiology and pathophysiology of stromal interaction molecules.
Nelson HA, Roe MW
(2018) Exp Biol Med (Maywood) 243: 451-472
MeSH Terms: Animals, Calcium, Calcium Channels, Calcium Signaling, Cell Line, Endoplasmic Reticulum, Humans, Mice, Neoplasm Proteins, Stromal Interaction Molecule 1, Stromal Interaction Molecule 2
Added July 6, 2018
0 Communities
1 Members
0 Resources
11 MeSH Terms