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RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission.
Shumate KM, Tas ST, Kavalali ET, Emeson RB
(2021) J Neurochem 158: 182-196
MeSH Terms: Adenosine Deaminase, Animals, CRISPR-Cas Systems, Calcium-Binding Proteins, Electrophysiological Phenomena, Glutamic Acid, High-Throughput Nucleotide Sequencing, Hippocampus, Mice, Mutation, Nerve Tissue Proteins, Neuronal Plasticity, Primary Cell Culture, RNA Editing, Synaptic Transmission, gamma-Aminobutyric Acid
Added April 30, 2021
1 Communities
0 Members
0 Resources
16 MeSH Terms
Systematic genome editing of the genes spanning an entire chromosome by CRISPR/Cas9 in a vertebrate-zebrafish (Danio rerio).
Gong Y, Yang B, Chen W
(2020) Sci China Life Sci 63: 1096-1097
MeSH Terms: Animals, Animals, Genetically Modified, Base Sequence, CRISPR-Associated Protein 9, CRISPR-Cas Systems, Chromosomes, Databases, Genetic, Gene Editing, Genome, Transcriptome, Zebrafish, Zebrafish Proteins
Added September 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
CRISPR/Cas9 engineering of albino cystinuria Type A mice.
Beckermann TM, Welch RC, Williams FM, Mortlock DP, Sha F, Ikizler TA, Woodard LE, Wilson MH
(2020) Genesis 58: e23357
MeSH Terms: Amino Acid Transport Systems, Basic, Amino Acid Transport Systems, Neutral, Animals, CRISPR-Cas Systems, Cysteine, Cystinuria, Disease Models, Animal, Mice, Mice, Inbred C57BL, Mutation
Added March 3, 2020
1 Communities
2 Members
0 Resources
10 MeSH Terms
Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether.
Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P
(2019) Elife 8:
MeSH Terms: ATP-Binding Cassette Transporters, Activating Transcription Factor 6, CRISPR-Cas Systems, Endoplasmic Reticulum, HEK293 Cells, Hep G2 Cells, Humans, Organelles, Peroxisomes, Phenotype, Protein Binding, Small Molecule Libraries, Unfolded Protein Response
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
NATF (Native and Tissue-Specific Fluorescence): A Strategy for Bright, Tissue-Specific GFP Labeling of Native Proteins in .
He S, Cuentas-Condori A, Miller DM
(2019) Genetics 212: 387-395
MeSH Terms: Animals, CRISPR-Cas Systems, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Fluorescence, Gene Editing, Green Fluorescent Proteins, Membrane Proteins, Nerve Tissue Proteins
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
CRISPR/Cas9 engineering of a KIM-1 reporter human proximal tubule cell line.
Veach RA, Wilson MH
(2018) PLoS One 13: e0204487
MeSH Terms: Acute Kidney Injury, CRISPR-Cas Systems, Cell Line, Cisplatin, Gene Knock-In Techniques, Gene Targeting, Genes, Reporter, Genetic Engineering, Glucose, Green Fluorescent Proteins, Hepatitis A Virus Cellular Receptor 1, Homologous Recombination, Humans, Kidney Tubules, Proximal, Luciferases, Up-Regulation
Added December 13, 2018
0 Communities
1 Members
0 Resources
16 MeSH Terms
Arrestins and G proteins in cellular signaling: The coin has two sides.
Gurevich VV, Gurevich EV
(2018) Sci Signal 11:
MeSH Terms: Arrestins, CRISPR-Cas Systems, Phosphorylation, RNA, Small Interfering, beta-Arrestins
Added March 18, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16.
Shi CH, Rubel C, Soss SE, Sanchez-Hodge R, Zhang S, Madrigal SC, Ravi S, McDonough H, Page RC, Chazin WJ, Patterson C, Mao CY, Willis MS, Luo HY, Li YS, Stevens DA, Tang MB, Du P, Wang YH, Hu ZW, Xu YM, Schisler JC
(2018) PLoS Genet 14: e1007664
MeSH Terms: Animals, Behavior, Animal, CRISPR-Cas Systems, Cognition, Disease Models, Animal, Female, Humans, Male, Mice, Mice, Inbred C57BL, Models, Molecular, Motor Activity, Mutagenesis, Site-Directed, Phenotype, Point Mutation, Protein Domains, Protein Multimerization, Rats, Rats, Sprague-Dawley, Spinocerebellar Ataxias, Ubiquitin-Protein Ligases
Added March 26, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Alteration of BDNF in the medial prefrontal cortex and the ventral hippocampus impairs extinction of avoidance.
Rosas-Vidal LE, Lozada-Miranda V, Cantres-Rosario Y, Vega-Medina A, Melendez L, Quirk GJ
(2018) Neuropsychopharmacology 43: 2636-2644
MeSH Terms: Animals, Avoidance Learning, Brain-Derived Neurotrophic Factor, CRISPR-Cas Systems, Cell Line, Tumor, Extinction, Psychological, Hippocampus, Male, Neural Pathways, Neuronal Plasticity, Prefrontal Cortex, Rats, Rats, Sprague-Dawley
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Knockdown of survivin results in inhibition of epithelial to mesenchymal transition in retinal pigment epithelial cells by attenuating the TGFβ pathway.
Zhang P, Zhao G, Ji L, Yin J, Lu L, Li W, Zhou G, Chaum E, Yue J
(2018) Biochem Biophys Res Commun 498: 573-578
MeSH Terms: CRISPR-Cas Systems, Cell Line, Cell Proliferation, Epithelial-Mesenchymal Transition, Humans, Inhibitor of Apoptosis Proteins, Retinal Pigment Epithelium, Signal Transduction, Survivin, Transforming Growth Factor beta, Vitreoretinopathy, Proliferative
Added June 11, 2018
0 Communities
1 Members
0 Resources
11 MeSH Terms