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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 192

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Biased M receptor-positive allosteric modulators reveal role of phospholipase D in M-dependent rodent cortical plasticity.
Moran SP, Xiang Z, Doyle CA, Maksymetz J, Lv X, Faltin S, Fisher NM, Niswender CM, Rook JM, Lindsley CW, Conn PJ
(2019) Sci Signal 12:
MeSH Terms: Allosteric Site, Animals, CHO Cells, Calcium, Cerebral Cortex, Cognition, Cricetinae, Cricetulus, Electrophysiology, Female, Humans, Long-Term Synaptic Depression, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Neuronal Plasticity, Phospholipase D, Prefrontal Cortex, Receptor, Muscarinic M1, Signal Transduction, Type C Phospholipases
Added March 3, 2020
0 Communities
2 Members
0 Resources
22 MeSH Terms
Multiple mechanisms underlie increased cardiac late sodium current.
Kroncke BM, Yang T, Roden DM
(2019) Heart Rhythm 16: 1091-1097
MeSH Terms: Action Potentials, Animals, CHO Cells, Cardiac Conduction System Disease, Cricetinae, Cricetulus, Genotype, Humans, Induced Pluripotent Stem Cells, Kidney, Long QT Syndrome, Myocytes, Cardiac, NAV1.5 Voltage-Gated Sodium Channel, Phenotype, Phosphatidylinositol 3-Kinases
Added March 26, 2019
0 Communities
3 Members
0 Resources
15 MeSH Terms
Human Serotonin Transporter Coding Variation Establishes Conformational Bias with Functional Consequences.
Quinlan MA, Krout D, Katamish RM, Robson MJ, Nettesheim C, Gresch PJ, Mash DC, Henry LK, Blakely RD
(2019) ACS Chem Neurosci 10: 3249-3260
MeSH Terms: Animals, CHO Cells, Cricetulus, Fenfluramine, Hippocampus, Humans, Mice, Neurons, Protein Conformation, Serotonin, Serotonin Plasma Membrane Transport Proteins, Serotonin Uptake Inhibitors
Added February 22, 2019
1 Communities
0 Members
0 Resources
12 MeSH Terms
Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein.
Gilchuk P, Kuzmina N, Ilinykh PA, Huang K, Gunn BM, Bryan A, Davidson E, Doranz BJ, Turner HL, Fusco ML, Bramble MS, Hoff NA, Binshtein E, Kose N, Flyak AI, Flinko R, Orlandi C, Carnahan R, Parrish EH, Sevy AM, Bombardi RG, Singh PK, Mukadi P, Muyembe-Tamfum JJ, Ohi MD, Saphire EO, Lewis GK, Alter G, Ward AB, Rimoin AW, Bukreyev A, Crowe JE
(2018) Immunity 49: 363-374.e10
MeSH Terms: 3T3 Cells, Adult, Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, CHO Cells, Cell Line, Chlorocebus aethiops, Cricetulus, Disease Models, Animal, Drosophila, Ebolavirus, Female, Ferrets, Glycoproteins, Guinea Pigs, Hemorrhagic Fever, Ebola, Humans, Immunoglobulin G, Jurkat Cells, Male, Mice, Mice, Inbred BALB C, Mice, Knockout, THP-1 Cells, Vero Cells
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
The discovery of VU0486846: steep SAR from a series of M PAMs based on a novel benzomorpholine core.
Bertron JL, Cho HP, Garcia-Barrantes PM, Panarese JD, Salovich JM, Nance KD, Engers DW, Rook JM, Blobaum AL, Niswender CM, Stauffer SR, Conn PJ, Lindsley CW
(2018) Bioorg Med Chem Lett 28: 2175-2179
MeSH Terms: Animals, CHO Cells, Cricetulus, Drug Discovery, Humans, Molecular Structure, Morpholines, Pyrazoles, Rats, Receptor, Muscarinic M1, Structure-Activity Relationship
Added March 3, 2020
0 Communities
2 Members
0 Resources
MeSH Terms
Regulation of Insulin Receptor Pathway and Glucose Metabolism by CD36 Signaling.
Samovski D, Dhule P, Pietka T, Jacome-Sosa M, Penrose E, Son NH, Flynn CR, Shoghi KI, Hyrc KL, Goldberg IJ, Gamazon ER, Abumrad NA
(2018) Diabetes 67: 1272-1284
MeSH Terms: Animals, CD36 Antigens, CHO Cells, Carbohydrate Metabolism, Cells, Cultured, Cricetinae, Cricetulus, Diabetes Mellitus, Type 2, Female, Glucose, Humans, Insulin, Insulin Resistance, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Muscle, Skeletal, Receptor, Insulin, Signal Transduction
Added May 26, 2018
0 Communities
2 Members
0 Resources
20 MeSH Terms
A Novel M PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity.
Rook JM, Bertron JL, Cho HP, Garcia-Barrantes PM, Moran SP, Maksymetz JT, Nance KD, Dickerson JW, Remke DH, Chang S, Harp JM, Blobaum AL, Niswender CM, Jones CK, Stauffer SR, Conn PJ, Lindsley CW
(2018) ACS Chem Neurosci 9: 2274-2285
MeSH Terms: Allosteric Regulation, Animals, Antipsychotic Agents, CHO Cells, Cognition, Cognitive Dysfunction, Conditioning, Psychological, Cricetulus, Exploratory Behavior, Fear, Mice, Morpholines, Prefrontal Cortex, Pyrazoles, Rats, Risperidone, Seizures
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
PF-06827443 Displays Robust Allosteric Agonist and Positive Allosteric Modulator Activity in High Receptor Reserve and Native Systems.
Moran SP, Cho HP, Maksymetz J, Remke DH, Hanson RM, Niswender CM, Lindsley CW, Rook JM, Conn PJ
(2018) ACS Chem Neurosci 9: 2218-2224
MeSH Terms: Allosteric Regulation, Animals, CHO Cells, Calcium, Cricetulus, Dogs, Humans, Isoindoles, Mice, Oxazoles, Patch-Clamp Techniques, Prefrontal Cortex, Rats, Receptor, Muscarinic M1, Seizures
Added March 3, 2020
0 Communities
2 Members
0 Resources
MeSH Terms
M-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition.
Moran SP, Dickerson JW, Cho HP, Xiang Z, Maksymetz J, Remke DH, Lv X, Doyle CA, Rajan DH, Niswender CM, Engers DW, Lindsley CW, Rook JM, Conn PJ
(2018) Neuropsychopharmacology 43: 1763-1771
MeSH Terms: Allosteric Regulation, Animals, CHO Cells, Cholinergic Agents, Cricetulus, Excitatory Postsynaptic Potentials, Male, Mice, Inbred C57BL, Nootropic Agents, Prefrontal Cortex, Pyramidal Cells, Rats, Rats, Sprague-Dawley, Receptor, Muscarinic M1, Recognition, Psychology, Tissue Culture Techniques
Added March 3, 2020
0 Communities
2 Members
0 Resources
MeSH Terms
Inhibition of the -Subunit of Phosphoinositide 3-Kinase in Heart Increases Late Sodium Current and Is Arrhythmogenic.
Yang T, Meoli DF, Moslehi J, Roden DM
(2018) J Pharmacol Exp Ther 365: 460-466
MeSH Terms: Action Potentials, Animals, Arrhythmias, Cardiac, CHO Cells, Cricetulus, Dose-Response Relationship, Drug, Electrophysiological Phenomena, Enzyme Inhibitors, Female, Heart, Mice, Mice, Inbred C57BL, Myocytes, Cardiac, Phosphoinositide-3 Kinase Inhibitors, Sodium
Added April 22, 2018
0 Communities
2 Members
0 Resources
15 MeSH Terms