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Results: 1 to 10 of 17

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In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice.
Cho SH, Guengerich FP
(2013) Chem Res Toxicol 26: 1765-74
MeSH Terms: Animals, Butadienes, Buthionine Sulfoximine, Chromatography, High Pressure Liquid, DNA Adducts, DNA Mutational Analysis, Epoxy Compounds, Ethylene Dibromide, Glutathione, Glutathione Transferase, Guanine, Liver, Male, Mice, Mice, Transgenic, Mutagenicity Tests, Mutation, Mutation Rate, O(6)-Methylguanine-DNA Methyltransferase, Spectrometry, Mass, Electrospray Ionization
Added March 7, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Ascorbic acid prevents oxidant-induced increases in endothelial permeability.
May JM, Qu ZC
(2011) Biofactors 37: 46-50
MeSH Terms: Antioxidants, Ascorbic Acid, Buthionine Sulfoximine, Cell Line, Endothelial Cells, Glutamate-Cysteine Ligase, Glutathione, Humans, Hydrogen Peroxide, Inulin, Oxidants, Permeability, Vitamin K 3
Added December 5, 2013
1 Communities
0 Members
0 Resources
13 MeSH Terms
Characterization of natural antimony resistance in Leishmania donovani isolates.
Mittal MK, Rai S, Ashutosh , Ravinder , Gupta S, Sundar S, Goyal N
(2007) Am J Trop Med Hyg 76: 681-8
MeSH Terms: Animals, Antimony, Antiprotozoal Agents, Buthionine Sulfoximine, Cells, Cultured, Drug Resistance, Gene Expression Regulation, Humans, Leishmania donovani, Leishmaniasis, Visceral, Sulfhydryl Compounds
Added July 10, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line.
Armstrong JS, Steinauer KK, Hornung B, Irish JM, Lecane P, Birrell GW, Peehl DM, Knox SJ
(2002) Cell Death Differ 9: 252-63
MeSH Terms: Antimetabolites, Antineoplastic, Apoptosis, Buthionine Sulfoximine, Cell Cycle, Cytochrome c Group, Cytosol, Dithiothreitol, Glutathione, Humans, Lymphoma, B-Cell, Membrane Potentials, Mitochondria, NF-kappa B, Protein Transport, Reactive Oxygen Species, Signal Transduction, Transcription Factor RelA, Tumor Cells, Cultured, Tumor Suppressor Protein p53
Added February 15, 2013
1 Communities
1 Members
0 Resources
19 MeSH Terms
GSH is required to recycle ascorbic acid in cultured liver cell lines.
Li X, Qu ZC, May JM
(2001) Antioxid Redox Signal 3: 1089-97
MeSH Terms: Animals, Arsenicals, Ascorbic Acid, Buthionine Sulfoximine, Cell Line, Cells, Cultured, Dose-Response Relationship, Drug, Enzyme Inhibitors, Glutathione, Humans, Kinetics, Liver, Maleates, NADP, Rats, Thioredoxin-Disulfide Reductase, Time Factors, Water
Added December 10, 2013
0 Communities
1 Members
0 Resources
18 MeSH Terms
Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by L-BSO and apoptosis.
Stokes AH, Lewis DY, Lash LH, Jerome WG, Grant KW, Aschner M, Vrana KE
(2000) Brain Res 858: 1-8
MeSH Terms: Apoptosis, Ascorbic Acid, Biological Assay, Buthionine Sulfoximine, Cell Membrane, Chromatography, High Pressure Liquid, DNA Fragmentation, Dopamine, Drug Synergism, Glutathione, Humans, Manganese, Microscopy, Electron, Scanning, Neuroblastoma, Oxidative Stress, Pyruvic Acid, Tumor Cells, Cultured
Added December 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
Synthesis of hsp-70 is enhanced in glutathione-depleted Hep G2 cells.
Freeman ML, Sierra-Rivera E, Voorhees GJ, Eisert DR, Meredith MJ
(1993) Radiat Res 135: 387-93
MeSH Terms: Buthionine Sulfoximine, Carmustine, Cells, Cultured, Dimethyl Sulfoxide, Glutathione, Heat-Shock Proteins, Hot Temperature, Humans, Methionine Sulfoximine, Oxidation-Reduction, RNA, Messenger
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Interactions of nitroglycerin and sulfhydryl-donating compounds in coronary microvessels.
Wheatley RM, Dockery SP, Kurz MA, Sayegh HS, Harrison DG
(1994) Am J Physiol 266: H291-7
MeSH Terms: Animals, Blood Vessels, Buffers, Buthionine Sulfoximine, Coronary Circulation, Cysteine, Dogs, Drug Interactions, Female, Glutathione, Male, Methionine Sulfoximine, Microcirculation, Nitric Oxide, Nitroglycerin, Oxygen, Sulfhydryl Compounds, Vasodilation
Added December 10, 2013
1 Communities
1 Members
0 Resources
18 MeSH Terms
Effect of selenium deficiency and glutathione-modulating agents on diquat toxicity and lipid peroxidation in rats.
Awad JA, Burk RF, Roberts LJ
(1994) J Pharmacol Exp Ther 270: 858-64
MeSH Terms: Animals, Antimetabolites, Arachidonic Acids, Buthionine Sulfoximine, Carmustine, Diquat, Glutathione, Ketones, Kidney, Lipid Peroxidation, Liver, Lung, Male, Methionine Sulfoximine, Rats, Rats, Inbred F344, Selenium
Added December 10, 2013
0 Communities
2 Members
0 Resources
17 MeSH Terms
Liver and kidney necrosis in selenium-deficient rats depleted of glutathione.
Burk RF, Hill KE, Awad JA, Morrow JD, Lyons PR
(1995) Lab Invest 72: 723-30
MeSH Terms: Animals, Buthionine Sulfoximine, Dinoprost, Glutathione, Ketones, Kidney, Lipid Peroxides, Liver, Male, Maleates, Methionine Sulfoximine, Necrosis, Osmolar Concentration, Proteins, Rats, Rats, Sprague-Dawley, Selenium, Selenoprotein P, Selenoproteins
Added March 5, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms