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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 31

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The use of venetoclax-based salvage therapy for post-hematopoietic cell transplantation relapse of acute myeloid leukemia.
Byrne M, Danielson N, Sengsayadeth S, Rasche A, Culos K, Gatwood K, Wyatt H, Chinratanalab W, Dholaria B, Ferrell PB, Fogo K, Goodman S, Jagasia M, Jayani R, Kassim A, Mohan SR, Savani BN, Strickland SA, Engelhardt BG, Savona M
(2020) Am J Hematol 95: 1006-1014
MeSH Terms: Adult, Aged, Allografts, Bridged Bicyclo Compounds, Heterocyclic, Disease-Free Survival, Female, Hematopoietic Stem Cell Transplantation, Humans, Leukemia, Myeloid, Acute, Male, Middle Aged, Salvage Therapy, Sulfonamides, Survival Rate
Added September 1, 2022
0 Communities
1 Members
0 Resources
MeSH Terms
Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.
Tian J, Teuscher KB, Aho ER, Alvarado JR, Mills JJ, Meyers KM, Gogliotti RD, Han C, Macdonald JD, Sai J, Shaw JG, Sensintaffar JL, Zhao B, Rietz TA, Thomas LR, Payne WG, Moore WJ, Stott GM, Kondo J, Inoue M, Coffey RJ, Tansey WP, Stauffer SR, Lee T, Fesik SW
(2020) J Med Chem 63: 656-675
MeSH Terms: Antineoplastic Agents, Bridged Bicyclo Compounds, Heterocyclic, Cell Cycle, Cell Line, Tumor, Cell Proliferation, Chromatin, Crystallography, X-Ray, Drug Design, Drug Discovery, Epigenetic Repression, Genes, myc, Humans, Intracellular Signaling Peptides and Proteins, Quinolones, Structure-Activity Relationship, WD40 Repeats
Added March 3, 2020
0 Communities
1 Members
0 Resources
16 MeSH Terms
Antagonism of the Thromboxane-Prostanoid Receptor as a Potential Therapy for Cardiomyopathy of Muscular Dystrophy.
West JD, Galindo CL, Kim K, Shin JJ, Atkinson JB, Macias-Perez I, Pavliv L, Knollmann BC, Soslow JH, Markham LW, Carrier EJ
(2019) J Am Heart Assoc 8: e011902
MeSH Terms: Animals, Bridged Bicyclo Compounds, Heterocyclic, Cardiomyopathies, Disease Models, Animal, Female, Male, Mice, Mice, Inbred mdx, Mice, Knockout, Muscular Dystrophy, Duchenne, Oxazoles, Prostaglandin Antagonists, Random Allocation, Receptors, Thromboxane
Added March 4, 2020
0 Communities
1 Members
0 Resources
14 MeSH Terms
Intraarterial administration of norcantharidin attenuates ischemic stroke damage in rodents when given at the time of reperfusion: novel uses of endovascular capabilities.
Khan IS, Odom M, Ehtesham M, Colvin D, Quarles CC, McLaughlin B, Singer RJ
(2016) J Neurosurg 125: 152-9
MeSH Terms: Animals, Brain Ischemia, Bridged Bicyclo Compounds, Heterocyclic, Disease Models, Animal, Injections, Intra-Arterial, Male, Matrix Metalloproteinase 9, Matrix Metalloproteinase Inhibitors, Rats, Stroke
Added April 25, 2016
1 Communities
1 Members
0 Resources
10 MeSH Terms
Multitargeting of selected prostanoid receptors provides agents with enhanced anti-inflammatory activity in macrophages.
Wang JW, Woodward DF, Martos JL, Cornell CL, Carling RW, Kingsley PJ, Marnett LJ
(2016) FASEB J 30: 394-404
MeSH Terms: Anti-Inflammatory Agents, Non-Steroidal, Bridged Bicyclo Compounds, Heterocyclic, Cells, Cultured, Cinnamates, Humans, Macrophages, Receptors, Prostaglandin, Receptors, Thromboxane, Substrate Specificity
Added February 22, 2016
0 Communities
2 Members
0 Resources
9 MeSH Terms
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead.
Jones CK, Sheffler DJ, Williams R, Jadhav SB, Felts AS, Morrison RD, Niswender CM, Daniels JS, Conn PJ, Lindsley CW
(2014) Bioorg Med Chem Lett 24: 1067-70
MeSH Terms: Bridged Bicyclo Compounds, Dose-Response Relationship, Drug, Glycine Plasma Membrane Transport Proteins, Humans, Molecular Structure, Piperidines, Structure-Activity Relationship
Added February 19, 2015
0 Communities
3 Members
0 Resources
7 MeSH Terms
A randomized, double-blind, placebo-controlled crossover study of α4β 2* nicotinic acetylcholine receptor agonist AZD1446 (TC-6683) in adults with attention-deficit/hyperactivity disorder.
Jucaite A, Öhd J, Potter AS, Jaeger J, Karlsson P, Hannesdottir K, Boström E, Newhouse PA, Paulsson B
(2014) Psychopharmacology (Berl) 231: 1251-65
MeSH Terms: Adult, Attention Deficit Disorder with Hyperactivity, Bridged Bicyclo Compounds, Heterocyclic, Cognition, Cross-Over Studies, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Nicotinic Agonists, Psychiatric Status Rating Scales, Receptors, Nicotinic, Time Factors, Tobacco Use Disorder, Treatment Outcome, Young Adult
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Isoprostanes as physiological mediators of transition to newborn life: novel mechanisms regulating patency of the term and preterm ductus arteriosus.
Chen JX, O'Mara PW, Poole SD, Brown N, Ehinger NJ, Slaughter JC, Paria BC, Aschner JL, Reese J
(2012) Pediatr Res 72: 122-8
MeSH Terms: Analysis of Variance, Animals, Animals, Newborn, Bridged Bicyclo Compounds, Heterocyclic, Dinoprost, Dinoprostone, Ductus Arteriosus, Ductus Arteriosus, Patent, Fatty Acids, Unsaturated, Female, Gas Chromatography-Mass Spectrometry, Gene Expression Profiling, Hydrazines, Isoprostanes, Mice, Myography, Oxidative Stress, Oxygen, Pregnancy, Premature Birth, Receptors, Prostaglandin E, EP4 Subtype, Receptors, Thromboxane A2, Prostaglandin H2, Vasodilation
Added May 26, 2015
0 Communities
1 Members
0 Resources
23 MeSH Terms
Pyridoxine-derived bicyclic aminopyridinol antioxidants: synthesis and their antioxidant activities.
Nam TG, Ku JM, Rector CL, Choi H, Porter NA, Jeong BS
(2011) Org Biomol Chem 9: 8475-82
MeSH Terms: Aminopyridines, Antioxidants, Bridged Bicyclo Compounds, Heterocyclic, Molecular Structure, Pyridoxine
Added March 7, 2014
0 Communities
1 Members
0 Resources
5 MeSH Terms
Cytoskeleton disruption in J774 macrophages: consequences for lipid droplet formation and cholesterol flux.
Weibel GL, Joshi MR, Jerome WG, Bates SR, Yu KJ, Phillips MC, Rothblat GH
(2012) Biochim Biophys Acta 1821: 464-72
MeSH Terms: Actin Cytoskeleton, Animals, Bridged Bicyclo Compounds, Heterocyclic, Cell Line, Cholesterol Esters, Cytochalasin D, Cytoskeletal Proteins, Foam Cells, Hydrolysis, Lipid Metabolism, Mice, Organelle Size, Organelles, Proteome, Sterol Esterase, Thiazolidines, Triglycerides
Added December 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms