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Results: 1 to 10 of 234

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Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions.
Rigg RA, Healy LD, Chu TT, Ngo ATP, Mitrugno A, Zilberman-Rudenko J, Aslan JE, Hinds MT, Vecchiarelli LD, Morgan TK, Gruber A, Temple KJ, Lindsley CW, Duvernay MT, Hamm HE, McCarty OJT
(2019) Platelets 30: 126-135
MeSH Terms: Animals, Biomarkers, Blood Platelets, Cell Communication, Cytoplasmic Granules, Flow Cytometry, Humans, Leukocytes, Male, Papio, Platelet Activation, Platelet Aggregation, Receptors, Thrombin
Added March 24, 2020
0 Communities
1 Members
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MeSH Terms
The role of coagulation and platelets in colon cancer-associated thrombosis.
Mitrugno A, Tassi Yunga S, Sylman JL, Zilberman-Rudenko J, Shirai T, Hebert JF, Kayton R, Zhang Y, Nan X, Shatzel JJ, Esener S, Duvernay MT, Hamm HE, Gruber A, Williams CD, Takata Y, Armstrong R, Morgan TK, McCarty OJT
(2019) Am J Physiol Cell Physiol 316: C264-C273
MeSH Terms: Blood Coagulation, Blood Platelets, Cell Line, Tumor, Colonic Neoplasms, Cross-Sectional Studies, Humans, Retrospective Studies, Thrombosis
Added March 24, 2020
0 Communities
1 Members
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MeSH Terms
Platelet-Based Drug Delivery for Cancer Applications.
Ortiz-Otero N, Mohamed Z, King MR
(2018) Adv Exp Med Biol 1092: 235-251
MeSH Terms: Blood Platelets, Drug Delivery Systems, Hemostasis, Humans, Male, Neoplasm Metastasis, Neoplasms
Added April 15, 2019
0 Communities
1 Members
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7 MeSH Terms
Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation in Human Platelets.
Duvernay MT, Temple KJ, Maeng JG, Blobaum AL, Stauffer SR, Lindsley CW, Hamm HE
(2017) Mol Pharmacol 91: 39-47
MeSH Terms: Blood Platelets, Humans, Integrin beta3, Ligands, Platelet Glycoprotein GPIb-IX Complex, Receptor, PAR-1, Receptors, Thrombin, Signal Transduction, Thrombin
Added March 24, 2020
0 Communities
1 Members
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MeSH Terms
Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazoles.
Temple KJ, Duvernay MT, Maeng JG, Blobaum AL, Stauffer SR, Hamm HE, Lindsley CW
(2016) Bioorg Med Chem Lett 26: 5481-5486
MeSH Terms: Blood Platelets, Humans, Platelet Aggregation, Platelet Aggregation Inhibitors, Receptors, Thrombin, Thiadiazoles, Thrombin
Added March 24, 2020
0 Communities
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Loss of Serotonin Transporter Function Alters ADP-mediated Glycoprotein αIIbβ3 Activation through Dysregulation of the 5-HT2A Receptor.
Oliver KH, Duvernay MT, Hamm HE, Carneiro AM
(2016) J Biol Chem 291: 20210-9
MeSH Terms: Adenosine Diphosphate, Animals, Blood Platelets, Citalopram, Female, Male, Mice, Mice, Knockout, Platelet Glycoprotein GPIIb-IIIa Complex, Receptor, Serotonin, 5-HT2A, Serotonin Plasma Membrane Transport Proteins
Added October 26, 2016
1 Communities
3 Members
0 Resources
11 MeSH Terms
Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals.
Eicher JD, Chami N, Kacprowski T, Nomura A, Chen MH, Yanek LR, Tajuddin SM, Schick UM, Slater AJ, Pankratz N, Polfus L, Schurmann C, Giri A, Brody JA, Lange LA, Manichaikul A, Hill WD, Pazoki R, Elliot P, Evangelou E, Tzoulaki I, Gao H, Vergnaud AC, Mathias RA, Becker DM, Becker LC, Burt A, Crosslin DR, Lyytikäinen LP, Nikus K, Hernesniemi J, Kähönen M, Raitoharju E, Mononen N, Raitakari OT, Lehtimäki T, Cushman M, Zakai NA, Nickerson DA, Raffield LM, Quarells R, Willer CJ, Peloso GM, Abecasis GR, Liu DJ, Global Lipids Genetics Consortium, Deloukas P, Samani NJ, Schunkert H, Erdmann J, CARDIoGRAM Exome Consortium, Myocardial Infarction Genetics Consortium, Fornage M, Richard M, Tardif JC, Rioux JD, Dube MP, de Denus S, Lu Y, Bottinger EP, Loos RJ, Smith AV, Harris TB, Launer LJ, Gudnason V, Velez Edwards DR, Torstenson ES, Liu Y, Tracy RP, Rotter JI, Rich SS, Highland HM, Boerwinkle E, Li J, Lange E, Wilson JG, Mihailov E, Mägi R, Hirschhorn J, Metspalu A, Esko T, Vacchi-Suzzi C, Nalls MA, Zonderman AB, Evans MK, Engström G, Orho-Melander M, Melander O, O'Donoghue ML, Waterworth DM, Wallentin L, White HD, Floyd JS, Bartz TM, Rice KM, Psaty BM, Starr JM, Liewald DC, Hayward C, Deary IJ, Greinacher A, Völker U, Thiele T, Völzke H, van Rooij FJ, Uitterlinden AG, Franco OH, Dehghan A, Edwards TL, Ganesh SK, Kathiresan S, Faraday N, Auer PL, Reiner AP, Lettre G, Johnson AD
(2016) Am J Hum Genet 99: 40-55
MeSH Terms: Blood Platelets, Exome, Female, Genetic Variation, Genome-Wide Association Study, Humans, Male, Mean Platelet Volume, Platelet Count
Added April 26, 2017
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9 MeSH Terms
Activated tumor cell integrin αvβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream.
Weber MR, Zuka M, Lorger M, Tschan M, Torbett BE, Zijlstra A, Quigley JP, Staflin K, Eliceiri BP, Krueger JS, Marchese P, Ruggeri ZM, Felding BH
(2016) Thromb Res 140 Suppl 1: S27-36
MeSH Terms: Animals, Blood Platelets, Cell Line, Tumor, Cell Movement, Humans, Integrin alphaVbeta3, Mice, SCID, Neoplasm Metastasis, Neoplastic Cells, Circulating
Added April 6, 2017
1 Communities
1 Members
0 Resources
9 MeSH Terms
Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin.
Bensing BA, Loukachevitch LV, McCulloch KM, Yu H, Vann KR, Wawrzak Z, Anderson S, Chen X, Sullam PM, Iverson TM
(2016) J Biol Chem 291: 7230-40
MeSH Terms: Adhesins, Bacterial, Binding Sites, Blood Platelets, Endocarditis, Humans, N-Acetylneuraminic Acid, Streptococcal Infections, Streptococcus, Virulence Factors
Added April 1, 2019
0 Communities
1 Members
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Platelet Lipidomic Profiling: Novel Insight into Cytosolic Phospholipase A2α Activity and Its Role in Human Platelet Activation.
Duvernay MT, Matafonov A, Lindsley CW, Hamm HE
(2015) Biochemistry 54: 5578-88
MeSH Terms: Benzoates, Blood Platelets, Glycerophospholipids, Group IV Phospholipases A2, Humans, Lipids, Oligopeptides, Peptide Fragments, Platelet Activation, Platelet Membrane Glycoproteins, Receptor, PAR-1, Receptors, Thrombin, Spectrometry, Mass, Electrospray Ionization, Stress, Mechanical, Sulfonamides, Thrombin
Added March 24, 2020
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MeSH Terms