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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 37

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Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6.
Shimada T, Takenaka S, Kakimoto K, Murayama N, Lim YR, Kim D, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M
(2016) Chem Res Toxicol 29: 1029-40
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Biphenyl Compounds, Cytochrome P-450 CYP2A6, Humans, Molecular Structure, Naphthalenes, Oxidation-Reduction, Phenanthrenes
Added March 14, 2018
0 Communities
1 Members
0 Resources
8 MeSH Terms
Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition.
Hubers SA, Brown NJ
(2016) Circulation 133: 1115-24
MeSH Terms: Abnormalities, Drug-Induced, Aminobutyrates, Angioedema, Angiotensin Receptor Antagonists, Biphenyl Compounds, Bradykinin, Contraindications, Drug Combinations, Drug Costs, Drug Synergism, Enalapril, Enzyme Inhibitors, Female, Follow-Up Studies, Heart Failure, Humans, Hyperkalemia, Hypertension, Kidney, Multicenter Studies as Topic, Natriuretic Peptides, Neprilysin, Pregnancy, Prodrugs, Prospective Studies, Pyridines, Randomized Controlled Trials as Topic, Stroke Volume, Tetrazoles, Thiazepines, Valsartan
Added April 6, 2017
0 Communities
1 Members
0 Resources
31 MeSH Terms
PIM kinase inhibitor AZD1208 for treatment of MYC-driven prostate cancer.
Kirschner AN, Wang J, van der Meer R, Anderson PD, Franco-Coronel OE, Kushner MH, Everett JH, Hameed O, Keeton EK, Ahdesmaki M, Grosskurth SE, Huszar D, Abdulkadir SA
(2015) J Natl Cancer Inst 107:
MeSH Terms: Administration, Oral, Allografts, Animals, Antineoplastic Agents, Apoptosis, Biphenyl Compounds, Cell Hypoxia, Cell Proliferation, Down-Regulation, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Genes, myc, Humans, Male, Mice, Prostatic Neoplasms, Prostatic Neoplasms, Castration-Resistant, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-pim-1, Thiazolidines, Tumor Suppressor Protein p53, Xenograft Model Antitumor Assays
Added January 21, 2015
0 Communities
1 Members
0 Resources
22 MeSH Terms
Visit-to-visit variability in blood pressure and kidney and cardiovascular outcomes in patients with type 2 diabetes and nephropathy: a post hoc analysis from the RENAAL study and the Irbesartan Diabetic Nephropathy Trial.
McMullan CJ, Lambers Heerspink HJ, Parving HH, Dwyer JP, Forman JP, de Zeeuw D
(2014) Am J Kidney Dis 64: 714-22
MeSH Terms: Aged, Angiotensin II Type 1 Receptor Blockers, Biphenyl Compounds, Blood Pressure, Cardiovascular Diseases, Cohort Studies, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Double-Blind Method, Female, Follow-Up Studies, Humans, Irbesartan, Kidney, Male, Middle Aged, Office Visits, Prospective Studies, Tetrazoles, Treatment Outcome
Added October 28, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Estimated GFR decline as a surrogate end point for kidney failure: a post hoc analysis from the Reduction of End Points in Non-Insulin-Dependent Diabetes With the Angiotensin II Antagonist Losartan (RENAAL) study and Irbesartan Diabetic Nephropathy Trial (IDNT).
Lambers Heerspink HJ, Weldegiorgis M, Inker LA, Gansevoort R, Parving HH, Dwyer JP, Mondal H, Coresh J, Greene T, Levey AS, de Zeeuw D
(2014) Am J Kidney Dis 63: 244-50
MeSH Terms: Aged, Angiotensin II Type 1 Receptor Blockers, Biomarkers, Biphenyl Compounds, Diabetes Mellitus, Type 2, Double-Blind Method, Female, Glomerular Filtration Rate, Humans, Irbesartan, Kidney Failure, Chronic, Losartan, Male, Middle Aged, Tetrazoles
Added October 28, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737.
Boiani M, Daniel C, Liu X, Hogarty MD, Marnett LJ
(2013) J Biol Chem 288: 6980-90
MeSH Terms: Adaptor Proteins, Signal Transducing, Antineoplastic Agents, Apoptosis, Apoptosis Regulatory Proteins, Biphenyl Compounds, Cell Line, Tumor, Cell Survival, Drug Resistance, Neoplasm, Gene Expression Regulation, Neoplastic, HEK293 Cells, Humans, Immunoblotting, Myeloid Cell Leukemia Sequence 1 Protein, Neoplasms, Nitrophenols, Piperazines, Proteasome Endopeptidase Complex, Protein Binding, Protein Stability, Proteolysis, Proto-Oncogene Proteins c-bcl-2, RNA Interference, Reverse Transcriptase Polymerase Chain Reaction, Sulfonamides, Ubiquitination
Added March 7, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms
Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode.
Digby GJ, Utley TJ, Lamsal A, Sevel C, Sheffler DJ, Lebois EP, Bridges TM, Wood MR, Niswender CM, Lindsley CW, Conn PJ
(2012) ACS Chem Neurosci 3: 1025-36
MeSH Terms: Allosteric Regulation, Allosteric Site, Animals, Benzamides, Biphenyl Compounds, CHO Cells, Cricetinae, Ligands, Muscarinic Agonists, Rats, Receptor, Muscarinic M1
Added March 7, 2014
1 Communities
3 Members
0 Resources
11 MeSH Terms
A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.
Yamanaka K, Dorjsuren D, Eoff RL, Egli M, Maloney DJ, Jadhav A, Simeonov A, Lloyd RS
(2012) PLoS One 7: e45032
MeSH Terms: Acrolein, Benzimidazoles, Biphenyl Compounds, Cell Line, Transformed, Cell Survival, DNA, DNA Adducts, DNA Damage, DNA Repair, DNA-Directed DNA Polymerase, Deoxyguanosine, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Enzyme Inhibitors, Humans, Indoles, Nucleic Acid Synthesis Inhibitors, Small Molecule Libraries, Terpenes, Tetrazoles, Ultraviolet Rays
Added May 27, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models.
Digby GJ, Noetzel MJ, Bubser M, Utley TJ, Walker AG, Byun NE, Lebois EP, Xiang Z, Sheffler DJ, Cho HP, Davis AA, Nemirovsky NE, Mennenga SE, Camp BW, Bimonte-Nelson HA, Bode J, Italiano K, Morrison R, Daniels JS, Niswender CM, Olive MF, Lindsley CW, Jones CK, Conn PJ
(2012) J Neurosci 32: 8532-44
MeSH Terms: Animals, Arrestins, Behavior, Animal, Benzamides, Biphenyl Compounds, Brain, CHO Cells, Calcium, Cell Line, Corpus Striatum, Cricetinae, Cricetulus, Extracellular Signal-Regulated MAP Kinases, Extracellular Space, Fear, Gene Expression Profiling, Hippocampus, Humans, Male, Maze Learning, Membrane Potentials, Mice, Mice, Inbred C57BL, Muscarinic Agonists, Phosphorylation, Prefrontal Cortex, Rats, Rats, Sprague-Dawley, Receptor, Muscarinic M1
Added March 7, 2014
1 Communities
5 Members
0 Resources
29 MeSH Terms
Albuminuria and blood pressure, independent targets for cardioprotective therapy in patients with diabetes and nephropathy: a post hoc analysis of the combined RENAAL and IDNT trials.
Holtkamp FA, de Zeeuw D, de Graeff PA, Laverman GD, Berl T, Remuzzi G, Packham D, Lewis JB, Parving HH, Lambers Heerspink HJ
(2011) Eur Heart J 32: 1493-9
MeSH Terms: Aged, Albuminuria, Amlodipine, Angiotensin Receptor Antagonists, Biphenyl Compounds, Blood Pressure, Calcium Channel Blockers, Cardiotonic Agents, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Diabetic Nephropathies, Female, Heart Failure, Humans, Hypertension, Irbesartan, Losartan, Male, Middle Aged, Myocardial Infarction, Randomized Controlled Trials as Topic, Retrospective Studies, Risk Factors, Stroke, Tetrazoles, Treatment Outcome
Added December 10, 2013
0 Communities
1 Members
0 Resources
26 MeSH Terms