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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 92

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Gut Microbiome and Response to Cardiovascular Drugs.
Tuteja S, Ferguson JF
(2019) Circ Genom Precis Med 12: 421-429
MeSH Terms: Animals, Bacteria, Biotransformation, Cardiovascular Agents, Gastrointestinal Microbiome, Gastrointestinal Tract, Humans
Added March 3, 2020
0 Communities
1 Members
0 Resources
7 MeSH Terms
Opportunities and Challenges in Cardiovascular Pharmacogenomics: From Discovery to Implementation.
Roden DM, Van Driest SL, Wells QS, Mosley JD, Denny JC, Peterson JF
(2018) Circ Res 122: 1176-1190
MeSH Terms: Biological Variation, Individual, Biotransformation, Cardiovascular Agents, Drug Development, Drug-Related Side Effects and Adverse Reactions, Forecasting, Genetic Association Studies, Genetic Predisposition to Disease, Genetic Testing, Genetic Variation, Genomics, Genotyping Techniques, Human Genome Project, Humans, Pharmacogenetics, Precision Medicine, Randomized Controlled Trials as Topic, Risk Assessment, Sample Size
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Mechanism of isoniazid-induced hepatotoxicity: then and now.
Metushi I, Uetrecht J, Phillips E
(2016) Br J Clin Pharmacol 81: 1030-6
MeSH Terms: Antitubercular Agents, Biotransformation, Chemical and Drug Induced Liver Injury, Humans, Isoniazid
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Dual drug delivery of tamoxifen and quercetin: Regulated metabolism for anticancer treatment with nanosponges.
Lockhart JN, Stevens DM, Beezer DB, Kravitz A, Harth E
(2015) J Control Release 220: 751-7
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Biological Availability, Biotransformation, Breast Neoplasms, Cell Line, Tumor, Cell Survival, Chemistry, Pharmaceutical, Cross-Linking Reagents, Cytochrome P-450 CYP3A, Delayed-Action Preparations, Dose-Response Relationship, Drug, Drug Carriers, Drug Stability, Female, Gastric Juice, Glucuronosyltransferase, Intestinal Secretions, Kinetics, Mice, Nanomedicine, Nanoparticles, Particle Size, Polyesters, Quercetin, Solubility, Tamoxifen
Added February 15, 2016
0 Communities
1 Members
0 Resources
27 MeSH Terms
VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis.
Lepesheva GI, Hargrove TY, Rachakonda G, Wawrzak Z, Pomel S, Cojean S, Nde PN, Nes WD, Locuson CW, Calcutt MW, Waterman MR, Daniels JS, Loiseau PM, Villalta F
(2015) J Infect Dis 212: 1439-48
MeSH Terms: Animals, Antiprotozoal Agents, Benzamides, Biotransformation, Chagas Disease, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Disease Models, Animal, Female, Humans, Imidazoles, Inhibitory Concentration 50, Leishmaniasis, Visceral, Mice, Mice, Inbred BALB C, Microsomes, Liver, Molecular Structure, Oxadiazoles, Rats, Structure-Activity Relationship, Tissue Distribution, Trypanosoma cruzi
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450.
Bojić M, Sedgeman CA, Nagy LD, Guengerich FP
(2015) Eur J Pharm Sci 73: 49-56
MeSH Terms: Aspirin, Benzaldehydes, Biotransformation, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Deferoxamine, Enzyme Inhibitors, Humans, Hydroxylation, Isoenzymes, Microsomes, Liver, NADP, Organophosphates, Oxidation-Reduction, Reactive Oxygen Species, Recombinant Proteins, Salicylic Acid
Added March 14, 2018
0 Communities
1 Members
0 Resources
17 MeSH Terms
Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals.
Rendic S, Guengerich FP
(2015) Chem Res Toxicol 28: 38-42
MeSH Terms: Biotransformation, Humans, Oxidoreductases, Xenobiotics
Added January 20, 2015
0 Communities
1 Members
0 Resources
4 MeSH Terms
Impact of structural and metabolic variations on the toxicity and carcinogenicity of hydroxy- and alkoxy-substituted allyl- and propenylbenzenes.
Rietjens IM, Cohen SM, Fukushima S, Gooderham NJ, Hecht S, Marnett LJ, Smith RL, Adams TB, Bastaki M, Harman CG, Taylor SV
(2014) Chem Res Toxicol 27: 1092-103
MeSH Terms: Animals, Benzene Derivatives, Biotransformation, Carcinogens, Humans
Added June 1, 2014
0 Communities
1 Members
0 Resources
5 MeSH Terms
Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor.
Murayama N, van Beuningen R, Suemizu H, Guillouzo CG, Shibata N, Yajima K, Utoh M, Shimizu M, Chesné C, Nakamura M, Guengerich FP, Houtman R, Yamazaki H
(2014) Chem Res Toxicol 27: 304-308
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Biotransformation, Cell Line, Cells, Cultured, Cytochrome P-450 CYP2B6, Cytochrome P-450 CYP3A, Hepatocytes, Humans, Pregnane X Receptor, Protein Array Analysis, Receptors, Cytoplasmic and Nuclear, Receptors, Steroid, Thalidomide
Added March 10, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Influence of dietary fat type on benzo(a)pyrene [B(a)P] biotransformation in a B(a)P-induced mouse model of colon cancer.
Diggs DL, Myers JN, Banks LD, Niaz MS, Hood DB, Roberts LJ, Ramesh A
(2013) J Nutr Biochem 24: 2051-63
MeSH Terms: Animals, Aryl Hydrocarbon Hydroxylases, Benzo(a)pyrene, Biotransformation, Carcinogens, Chromatography, Thin Layer, Colon, Colonic Neoplasms, Cytochrome P-450 CYP1B1, DNA Adducts, Dietary Fats, Disease Models, Animal, Liver, Male, Mice
Added March 7, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms