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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 59

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The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (/) of CK1α.
Shen C, Li B, Astudillo L, Deutscher MP, Cobb MH, Capobianco AJ, Lee E, Robbins DJ
(2019) Biochemistry 58: 5102-5106
MeSH Terms: Biocatalysis, Casein Kinase Ialpha, Enzyme Activation, HEK293 Cells, Humans, Kinetics, Pyrvinium Compounds
Added December 22, 2019
0 Communities
1 Members
0 Resources
7 MeSH Terms
Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications.
Li Z, Jiang Y, Guengerich FP, Ma L, Li S, Zhang W
(2020) J Biol Chem 295: 833-849
MeSH Terms: Biocatalysis, Biotechnology, Cytochrome P-450 Enzyme System, Metabolic Engineering, Protein Engineering, Steroids, Substrate Specificity, Xenobiotics
Added March 3, 2020
0 Communities
1 Members
0 Resources
8 MeSH Terms
Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone.
Reddish MJ, Guengerich FP
(2019) J Biol Chem 294: 12975-12991
MeSH Terms: 18-Hydroxycorticosterone, Aldosterone, Biocatalysis, Cytochrome P-450 CYP11B2, Humans, Kinetics, Models, Molecular, Molecular Conformation
Added March 3, 2020
0 Communities
1 Members
0 Resources
8 MeSH Terms
Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51.
Hargrove TY, Wawrzak Z, Fisher PM, Child SA, Nes WD, Guengerich FP, Waterman MR, Lepesheva GI
(2018) J Biol Chem 293: 19344-19353
MeSH Terms: Biocatalysis, Electron Transport, Enzyme Stability, Heme, Models, Molecular, Protein Binding, Protein Conformation, Sterol 14-Demethylase, Trypanosoma cruzi
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Sulfenylation of Human Liver and Kidney Microsomal Cytochromes P450 and Other Drug-Metabolizing Enzymes as a Response to Redox Alteration.
Albertolle ME, Phan TTN, Pozzi A, Guengerich FP
(2018) Mol Cell Proteomics 17: 889-900
MeSH Terms: Animals, Biocatalysis, Cysteine, Cytochrome P-450 Enzyme System, Humans, Hydrogen Peroxide, Kidney, Mice, Transgenic, Microsomes, Liver, Oxidation-Reduction, Pharmaceutical Preparations, Recombinant Proteins, Staining and Labeling, Sulfenic Acids, Sulfhydryl Compounds
Added March 14, 2018
1 Communities
1 Members
0 Resources
15 MeSH Terms
Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer.
Bhuripanyo K, Wang Y, Liu X, Zhou L, Liu R, Duong D, Zhao B, Bi Y, Zhou H, Chen G, Seyfried NT, Chazin WJ, Kiyokawa H, Yin J
(2018) Sci Adv 4: e1701393
MeSH Terms: Amino Acid Sequence, Bacteriophages, Biocatalysis, Cyclin-Dependent Kinase 4, Endoplasmic Reticulum Stress, HEK293 Cells, Humans, Mutant Proteins, Mutation, Peptides, Proteolysis, Reproducibility of Results, Signal Transduction, Substrate Specificity, Tumor Suppressor Protein p53, Tumor Suppressor Proteins, Ubiquitin, Ubiquitin-Protein Ligase Complexes, Ubiquitin-Protein Ligases, Ubiquitination
Added March 24, 2018
0 Communities
1 Members
0 Resources
20 MeSH Terms
Kinetic Deuterium Isotope Effects in Cytochrome P450 Reactions.
Guengerich FP
(2017) Methods Enzymol 596: 217-238
MeSH Terms: Biocatalysis, Cytochrome P-450 Enzyme System, Deuterium, Enzyme Assays, Humans, Hydrogen Bonding, Kinetics, Models, Chemical, Oxidation-Reduction, Substrate Specificity
Added March 14, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates -retinol to 3,4-dehydroretinol.
Johnson KM, Phan TTN, Albertolle ME, Guengerich FP
(2017) J Biol Chem 292: 13672-13687
MeSH Terms: Biocatalysis, Cytochrome P450 Family 27, Diterpenes, Gene Expression Profiling, Gene Expression Regulation, Enzymologic, Humans, Hydrogenation, Hydroxylation, Isoenzymes, Kinetics, Mitochondria, Molecular Structure, Organ Specificity, Oxidation-Reduction, Peptide Fragments, Proteolysis, Proteomics, Skin, Stereoisomerism, Substrate Specificity, Vitamin A
Added March 14, 2018
0 Communities
1 Members
0 Resources
21 MeSH Terms
Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.
Gonzalez E, Guengerich FP
(2017) J Biol Chem 292: 13168-13185
MeSH Terms: 17-alpha-Hydroxypregnenolone, Androstenedione, Animals, Binding Sites, Biocatalysis, Cytochrome P-450 Enzyme Inhibitors, Cytochromes b5, Dehydroepiandrosterone, Humans, Imidazoles, Kinetics, Ligands, Models, Molecular, NADPH-Ferrihemoprotein Reductase, Naphthalenes, Oxidation-Reduction, Pregnenolone, Progesterone, Protein Conformation, Rats, Recombinant Proteins, Stereoisomerism, Steroid 17-alpha-Hydroxylase
Added March 14, 2018
0 Communities
1 Members
0 Resources
23 MeSH Terms
Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants.
Shimada T, Murayama N, Kakimoto K, Takenaka S, Lim YR, Yeom S, Kim D, Yamazaki H, Guengerich FP, Komori M
(2018) Xenobiotica 48: 565-575
MeSH Terms: Alleles, Aryl Hydrocarbon Hydroxylases, Biocatalysis, Cytochrome P-450 CYP1B1, Humans, Molecular Docking Simulation, Oxidation-Reduction, Pyrenes
Added March 14, 2018
0 Communities
1 Members
0 Resources
8 MeSH Terms