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Human antibody recognition of antigenic site IV on Pneumovirus fusion proteins.
Mousa JJ, Binshtein E, Human S, Fong RH, Alvarado G, Doranz BJ, Moore ML, Ohi MD, Crowe JE
(2018) PLoS Pathog 14: e1006837
MeSH Terms: Amino Acid Sequence, Amino Acid Substitution, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Antibody Specificity, Binding Sites, Antibody, Binding, Competitive, Cross Reactions, Epitope Mapping, Epitopes, Humans, Kinetics, Metapneumovirus, Microscopy, Electron, Mutation, Recombinant Proteins, Respiratory Syncytial Virus, Human, Viral Fusion Proteins
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein.
Sangha AK, Dong J, Williamson L, Hashiguchi T, Saphire EO, Crowe JE, Meiler J
(2017) Structure 25: 1820-1828.e2
MeSH Terms: Antibodies, Monoclonal, Antibodies, Neutralizing, Antibody Affinity, Binding Sites, Antibody, Molecular Docking Simulation, Protein Binding, Viral Envelope Proteins
Added March 14, 2018
0 Communities
2 Members
0 Resources
7 MeSH Terms
Epitope and Paratope Mapping Reveals Temperature-Dependent Alterations in the Dengue-Antibody Interface.
Lim XX, Chandramohan A, Lim XE, Crowe JE, Lok SM, Anand GS
(2017) Structure 25: 1391-1402.e3
MeSH Terms: Antibodies, Neutralizing, Antibodies, Viral, Binding Sites, Antibody, Dengue Virus, Deuterium Exchange Measurement, Epitope Mapping, Epitopes, Humans, Mass Spectrometry, Models, Molecular, Protein Binding, Protein Conformation, Temperature, Viral Envelope Proteins
Added March 14, 2018
0 Communities
1 Members
0 Resources
14 MeSH Terms
Use of a neutralizing antibody helps identify structural features critical for binding of toxin TcdA to the host cell surface.
Kroh HK, Chandrasekaran R, Rosenthal K, Woods R, Jin X, Ohi MD, Nyborg AC, Rainey GJ, Warrener P, Spiller BW, Lacy DB
(2017) J Biol Chem 292: 14401-14412
MeSH Terms: Amino Acid Sequence, Anti-Bacterial Agents, Antibodies, Monoclonal, Humanized, Antibodies, Neutralizing, Bacterial Proteins, Bacterial Toxins, Binding Sites, Antibody, Caco-2 Cells, Clostridioides difficile, Conserved Sequence, Crystallography, X-Ray, Enterocytes, Enterotoxins, Epitope Mapping, Glucosyltransferases, Humans, Immunoglobulin Fab Fragments, Models, Molecular, Peptide Fragments, Protein Conformation, Protein Interaction Domains and Motifs, Recombinant Proteins, Repetitive Sequences, Amino Acid
Added March 15, 2018
0 Communities
3 Members
0 Resources
23 MeSH Terms
Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.
Huang J, Kang BH, Ishida E, Zhou T, Griesman T, Sheng Z, Wu F, Doria-Rose NA, Zhang B, McKee K, O'Dell S, Chuang GY, Druz A, Georgiev IS, Schramm CA, Zheng A, Joyce MG, Asokan M, Ransier A, Darko S, Migueles SA, Bailer RT, Louder MK, Alam SM, Parks R, Kelsoe G, Von Holle T, Haynes BF, Douek DC, Hirsch V, Seaman MS, Shapiro L, Mascola JR, Kwong PD, Connors M
(2016) Immunity 45: 1108-1121
MeSH Terms: Antibodies, Neutralizing, Antibody Specificity, Binding Sites, Antibody, CD4-Positive T-Lymphocytes, Cell Separation, HIV Antibodies, HIV Envelope Protein gp120, HIV Infections, HIV-1, Humans
Added May 3, 2017
0 Communities
1 Members
0 Resources
10 MeSH Terms
H7N9 influenza virus neutralizing antibodies that possess few somatic mutations.
Thornburg NJ, Zhang H, Bangaru S, Sapparapu G, Kose N, Lampley RM, Bombardi RG, Yu Y, Graham S, Branchizio A, Yoder SM, Rock MT, Creech CB, Edwards KM, Lee D, Li S, Wilson IA, García-Sastre A, Albrecht RA, Crowe JE
(2016) J Clin Invest 126: 1482-94
MeSH Terms: Adult, Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Binding Sites, Antibody, Epitope Mapping, Epitopes, Female, Humans, Influenza A Virus, H7N9 Subtype, Influenza Vaccines, Male, Mice, Middle Aged, Mutation
Added May 4, 2016
0 Communities
1 Members
0 Resources
16 MeSH Terms
Differential accessibility of a rotavirus VP6 epitope in trimers comprising type I, II, or III channels as revealed by binding of a human rotavirus VP6-specific antibody.
Aiyegbo MS, Eli IM, Spiller BW, Williams DR, Kim R, Lee DE, Liu T, Li S, Stewart PL, Crowe JE
(2014) J Virol 88: 469-76
MeSH Terms: Amino Acid Sequence, Antibodies, Viral, Antigens, Viral, Base Sequence, Binding Sites, Antibody, Biopolymers, Capsid Proteins, Cryoelectron Microscopy, DNA Primers, Epitopes, Mass Spectrometry, Molecular Sequence Data
Added March 7, 2014
0 Communities
2 Members
0 Resources
12 MeSH Terms
Antibody recognition of the pandemic H1N1 Influenza virus hemagglutinin receptor binding site.
Hong M, Lee PS, Hoffman RM, Zhu X, Krause JC, Laursen NS, Yoon SI, Song L, Tussey L, Crowe JE, Ward AB, Wilson IA
(2013) J Virol 87: 12471-80
MeSH Terms: Antibodies, Viral, Antibody Affinity, Antigens, Viral, Binding Sites, Antibody, Crystallography, X-Ray, Hemagglutinin Glycoproteins, Influenza Virus, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human, Models, Molecular, Pandemics, Protein Conformation, Receptors, Virus, United States
Added March 7, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Engineered protease-resistant antibodies with selectable cell-killing functions.
Kinder M, Greenplate AR, Grugan KD, Soring KL, Heeringa KA, McCarthy SG, Bannish G, Perpetua M, Lynch F, Jordan RE, Strohl WR, Brezski RJ
(2013) J Biol Chem 288: 30843-54
MeSH Terms: Antibodies, Monoclonal, Antibody-Dependent Cell Cytotoxicity, Binding Sites, Antibody, Cell Line, Humans, Immunoglobulin G, Protein Engineering, Proteolysis, Receptors, IgG
Added March 27, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Influenza human monoclonal antibody 1F1 interacts with three major antigenic sites and residues mediating human receptor specificity in H1N1 viruses.
Tsibane T, Ekiert DC, Krause JC, Martinez O, Crowe JE, Wilson IA, Basler CF
(2012) PLoS Pathog 8: e1003067
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Viral, Antibody Affinity, Binding Sites, Antibody, Crystallography, X-Ray, Epitopes, Hemagglutinin Glycoproteins, Influenza Virus, Humans, Immunoglobulin Heavy Chains, Influenza A Virus, H1N1 Subtype, Mice, Mutagenesis, Site-Directed, Protein Structure, Quaternary
Added January 26, 2016
0 Communities
1 Members
0 Resources
14 MeSH Terms