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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 12

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7,8-benzoflavone binding to human cytochrome P450 3A4 reveals complex fluorescence quenching, suggesting binding at multiple protein sites.
Marsch GA, Carlson BT, Guengerich FP
(2018) J Biomol Struct Dyn 36: 841-860
MeSH Terms: Benzoflavones, Binding Sites, Cytochrome P-450 CYP3A, Fluorescence, Humans, Kinetics, Ligands, Models, Chemical, Oxidation-Reduction, Protein Binding, Spectrometry, Fluorescence, Substrate Specificity
Added March 14, 2018
0 Communities
1 Members
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12 MeSH Terms
Cooperativity in oxidations catalyzed by cytochrome P450 3A4.
Ueng YF, Kuwabara T, Chun YJ, Guengerich FP
(1997) Biochemistry 36: 370-81
MeSH Terms: Aflatoxin B1, Amitriptyline, Benzoflavones, Carbamazepine, Chromatography, High Pressure Liquid, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System, Cytochromes b5, Diazepam, Estradiol, Humans, Hydroxylation, Kinetics, Magnesium Chloride, Microsomes, Liver, Mixed Function Oxygenases, Models, Chemical, Oxidation-Reduction, Substrate Specificity, Testosterone
Added March 5, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme.
Sandhu P, Guo Z, Baba T, Martin MV, Tukey RH, Guengerich FP
(1994) Arch Biochem Biophys 309: 168-77
MeSH Terms: Amino Acid Sequence, Base Sequence, Benzoflavones, Catalysis, Cytochrome P-450 CYP1A2, Cytochrome P-450 Enzyme System, Enzyme Stability, Escherichia coli, Gene Expression, Humans, Microsomes, Liver, Molecular Sequence Data, Nucleic Acid Hybridization, Oxidoreductases, Protein Structure, Secondary, Recombinant Proteins, Sequence Analysis, Spectrophotometry
Added March 5, 2014
0 Communities
1 Members
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18 MeSH Terms
Activation of procarcinogens by human cytochrome P450 enzymes expressed in Escherichia coli. Simplified bacterial systems for genotoxicity assays.
Shimada T, Gillam EM, Sandhu P, Guo Z, Tukey RH, Guengerich FP
(1994) Carcinogenesis 15: 2523-9
MeSH Terms: Amino Acid Sequence, Benzoflavones, Biotransformation, Carcinogens, Cytochrome P-450 Enzyme System, Escherichia coli, Humans, Microsomes, Liver, Molecular Sequence Data, Mutagenicity Tests, Recombinant Proteins
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes.
Bauer E, Guo Z, Ueng YF, Bell LC, Zeldin D, Guengerich FP
(1995) Chem Res Toxicol 8: 136-42
MeSH Terms: Benzo(a)pyrene, Benzoflavones, Biotransformation, Cytochrome P-450 Enzyme System, Humans, Oxidation-Reduction, Recombinant Proteins
Added March 5, 2014
0 Communities
1 Members
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7 MeSH Terms
Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.
Shimada T, Guengerich FP
(1989) Proc Natl Acad Sci U S A 86: 462-5
MeSH Terms: Aflatoxin B1, Aflatoxins, Antibodies, Benzoflavones, Biotransformation, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System, Humans, Immunochemistry, Microsomes, Liver, Mixed Function Oxygenases, Nifedipine, Oxidation-Reduction, Sterigmatocystin, Troleandomycin
Added March 5, 2014
0 Communities
1 Members
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15 MeSH Terms
Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes.
Shimada T, Guengerich FP
(1991) Cancer Res 51: 5284-91
MeSH Terms: Aflatoxin B1, Animals, Aroclors, Benzoflavones, Carbolines, Chlorodiphenyl (54% Chlorine), Cytochrome P-450 Enzyme System, DNA, Dose-Response Relationship, Drug, Humans, Imidazoles, In Vitro Techniques, Male, Microsomes, Liver, Mutagens, Plants, Toxic, Quinidine, Rats, Rats, Inbred Strains, SOS Response, Genetics, Safrole, Smoke, Tobacco, beta-Galactosidase
Added March 5, 2014
0 Communities
1 Members
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24 MeSH Terms
Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4'-methylene-bis(2-chloroaniline).
Yun CH, Shimada T, Guengerich FP
(1992) Carcinogenesis 13: 217-22
MeSH Terms: Benzoflavones, Cytochrome P-450 Enzyme System, Humans, Methylenebis(chloroaniline), Microsomes, Liver, Oxidation-Reduction, Recombinant Proteins
Added March 5, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms
Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4.
Fleming CM, Branch RA, Wilkinson GR, Guengerich FP
(1992) Mol Pharmacol 41: 975-80
MeSH Terms: Antibodies, Benzoflavones, Cytochrome P-450 Enzyme System, Humans, Hydroxylation, Isoenzymes, Kinetics, Microsomes, Liver, Norpregnenes, Troleandomycin
Added March 5, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Roles of human liver cytochrome P4502C and 3A enzymes in the 3-hydroxylation of benzo(a)pyrene.
Yun CH, Shimada T, Guengerich FP
(1992) Cancer Res 52: 1868-74
MeSH Terms: Antibodies, Benzo(a)pyrene, Benzoflavones, Cytochrome P-450 Enzyme System, Gene Expression, Humans, Hydroxylation, Isoenzymes, Kinetics, Liver, Microsomes, Liver, Norpregnenes, Recombinant Proteins, Saccharomyces cerevisiae, Sulfaphenazole
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms