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Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas.
Schaub FX, Dhankani V, Berger AC, Trivedi M, Richardson AB, Shaw R, Zhao W, Zhang X, Ventura A, Liu Y, Ayer DE, Hurlin PJ, Cherniack AD, Eisenman RN, Bernard B, Grandori C, Cancer Genome Atlas Network
(2018) Cell Syst 6: 282-300.e2
MeSH Terms: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Basic Helix-Loop-Helix Transcription Factors, Biomarkers, Tumor, Carcinogenesis, Chromatin, Computational Biology, Genes, myc, Genomics, Humans, Neoplasms, Oncogenes, Proteomics, Proto-Oncogene Proteins c-myc, Repressor Proteins, Signal Transduction, Transcription Factors
Added October 30, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
Zeng C, Matsuda K, Jia WH, Chang J, Kweon SS, Xiang YB, Shin A, Jee SH, Kim DH, Zhang B, Cai Q, Guo X, Long J, Wang N, Courtney R, Pan ZZ, Wu C, Takahashi A, Shin MH, Matsuo K, Matsuda F, Gao YT, Oh JH, Kim S, Jung KJ, Ahn YO, Ren Z, Li HL, Wu J, Shi J, Wen W, Yang G, Li B, Ji BT, Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Brenner H, Schoen RE, Küry S, Colorectal Transdisciplinary (CORECT) Study, Gruber SB, Schumacher FR, Stenzel SL, Colon Cancer Family Registry (CCFR), Casey G, Hopper JL, Jenkins MA, Kim HR, Jeong JY, Park JW, Tajima K, Cho SH, Kubo M, Shu XO, Lin D, Zeng YX, Zheng W
(2016) Gastroenterology 150: 1633-1645
MeSH Terms: Adult, Aged, Asians, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Case-Control Studies, Colorectal Neoplasms, Eukaryotic Initiation Factor-3, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Qb-SNARE Proteins, Ribosomal Proteins, Risk Factors, Steroid 17-alpha-Hydroxylase, Suppressor of Cytokine Signaling Proteins, Young Adult
Added May 4, 2017
0 Communities
2 Members
0 Resources
21 MeSH Terms
The MYC-WDR5 Nexus and Cancer.
Thomas LR, Foshage AM, Weissmiller AM, Tansey WP
(2015) Cancer Res 75: 4012-5
MeSH Terms: Antineoplastic Agents, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Chromatin Assembly and Disassembly, DNA, DNA Methylation, Drug Discovery, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Genes, myc, Histone-Lysine N-Methyltransferase, Histones, Humans, Intracellular Signaling Peptides and Proteins, Models, Genetic, Molecular Targeted Therapy, Neoplasm Proteins, Neoplasms, Protein Binding, Proto-Oncogene Proteins c-myc, Repressor Proteins, Signal Transduction
Added March 26, 2019
0 Communities
1 Members
0 Resources
21 MeSH Terms
Alveolar soft part sarcoma and granular cell tumor: an immunohistochemical comparison study.
Chamberlain BK, McClain CM, Gonzalez RS, Coffin CM, Cates JM
(2014) Hum Pathol 45: 1039-44
MeSH Terms: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Calbindin 2, Granular Cell Tumor, Humans, Immunohistochemistry, Inhibins, Nestin, S100 Proteins, SOXE Transcription Factors, Sarcoma, Alveolar Soft Part, Sensitivity and Specificity, Staining and Labeling
Added February 15, 2016
0 Communities
1 Members
0 Resources
12 MeSH Terms
A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.
Zhang X, Garbett K, Veeraraghavalu K, Wilburn B, Gilmore R, Mirnics K, Sisodia SS
(2012) J Neurosci 32: 8633-48
MeSH Terms: Animals, Autophagy, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Blastocyst, Blotting, Western, Cathepsin D, Cell Line, Tumor, Cells, Cultured, DNA Primers, Gene Expression, Humans, Hydrogen-Ion Concentration, Lysosomes, Mice, Mice, Knockout, Neurons, Polymerase Chain Reaction, Presenilin-1, Presenilin-2, Presenilins, RNA, RNA, Small Interfering, Vacuolar Proton-Translocating ATPases
Added May 19, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
Attenuation of the beta-catenin/TCF4 complex in colorectal cancer cells induces several growth-suppressive microRNAs that target cancer promoting genes.
Schepeler T, Holm A, Halvey P, Nordentoft I, Lamy P, Riising EM, Christensen LL, Thorsen K, Liebler DC, Helin K, Ørntoft TF, Andersen CL
(2012) Oncogene 31: 2750-60
MeSH Terms: Aged, Aged, 80 and over, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Cell Line, Tumor, Cell Proliferation, Chromatography, Liquid, Colon, Colorectal Neoplasms, Female, Gene Expression Profiling, Genes, Dominant, Humans, Luciferases, Male, MicroRNAs, Middle Aged, Oligonucleotide Array Sequence Analysis, Oncogenes, RNA, Messenger, RNA, Small Interfering, Rectum, Reverse Transcriptase Polymerase Chain Reaction, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Transcription Factor 4, Transcription Factors, Transcriptome, Tumor Cells, Cultured, Wnt Signaling Pathway, beta Catenin
Added March 20, 2014
0 Communities
1 Members
0 Resources
29 MeSH Terms
Impaired-inactivation of FoxO1 contributes to glucose-mediated increases in serum very low-density lipoprotein.
Wu K, Cappel D, Martinez M, Stafford JM
(2010) Endocrinology 151: 3566-76
MeSH Terms: Adenoviridae, Animals, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Cell Nucleus, Forkhead Transcription Factors, Glucose, Glucose Clamp Technique, Hyperinsulinism, Insulin, Lipid Metabolism, Lipoproteins, VLDL, Liver, Male, Nerve Tissue Proteins, Rats, Rats, Long-Evans, Rats, Transgenic, Transduction, Genetic, Up-Regulation
Added October 8, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
Hepatic glucose sensing: does flux matter?
Shiota M, Magnuson MA
(2008) J Clin Invest 118: 841-4
MeSH Terms: Animals, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, DNA-Binding Proteins, Gene Expression Regulation, Glucose, Lipogenesis, Liver, Liver X Receptors, Mice, Nuclear Proteins, Orphan Nuclear Receptors, Receptors, Cytoplasmic and Nuclear, Sterol Regulatory Element Binding Protein 1, Transcription Factors
Added February 23, 2011
1 Communities
2 Members
0 Resources
14 MeSH Terms
TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.
Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N
(2006) Nat Med 12: 107-13
MeSH Terms: Adenoviridae, Animals, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Blood Glucose, Blotting, Northern, Cells, Cultured, Chromatin Immunoprecipitation, Cloning, Molecular, Diabetes Mellitus, Diabetes Mellitus, Experimental, Dose-Response Relationship, Drug, Glycogen, Glycogen Synthase Kinase 3, Glycogen Synthase Kinase 3 beta, Green Fluorescent Proteins, Hepatocytes, Hexokinase, Humans, Immunoblotting, Immunoprecipitation, Insulin, Insulin Receptor Substrate Proteins, Intracellular Signaling Peptides and Proteins, Male, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Biological, Phosphoproteins, Phosphorylation, Plasmids, Promoter Regions, Genetic, Protein Structure, Tertiary, Proto-Oncogene Proteins c-akt, Rats, Ribosomal Protein S6 Kinases, 70-kDa, Signal Transduction, Streptozocin, Time Factors, Transcriptional Activation
Added March 27, 2013
0 Communities
1 Members
0 Resources
41 MeSH Terms
Control of pancreas and liver gene expression by HNF transcription factors.
Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA
(2004) Science 303: 1378-81
MeSH Terms: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Carbohydrate Metabolism, DNA-Binding Proteins, Diabetes Mellitus, Type 2, Gene Expression Profiling, Gene Expression Regulation, Genome, Human, Gluconeogenesis, Hepatocyte Nuclear Factor 1, Hepatocyte Nuclear Factor 1-alpha, Hepatocyte Nuclear Factor 1-beta, Hepatocyte Nuclear Factor 4, Hepatocyte Nuclear Factor 6, Hepatocytes, Homeodomain Proteins, Humans, Islets of Langerhans, Lipid Metabolism, Nuclear Proteins, Oligonucleotide Array Sequence Analysis, Phosphoproteins, Precipitin Tests, Promoter Regions, Genetic, RNA Polymerase II, Trans-Activators, Transcription Factors, Transcription, Genetic
Added April 19, 2011
0 Communities
0 Members
1 Resources
27 MeSH Terms