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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 54

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Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage.
Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR
(2017) Nature 551: 464-471
MeSH Terms: Adenosine Deaminase, Base Pairing, CRISPR-Associated Proteins, Cell Line, Tumor, DNA, DNA Cleavage, Gene Editing, Genome, Human, HEK293 Cells, Humans, Models, Molecular, Polymorphism, Single Nucleotide
Added March 13, 2018
0 Communities
0 Members
1 Resources
12 MeSH Terms
Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity.
Komor AC, Zhao KT, Packer MS, Gaudelli NM, Waterbury AL, Koblan LW, Kim YB, Badran AH, Liu DR
(2017) Sci Adv 3: eaao4774
MeSH Terms: Bacteriophage mu, Base Pairing, Cell Line, DNA Repair, DNA-Binding Proteins, Enzyme Activation, Gene Frequency, Gene Order, Humans, INDEL Mutation, Uracil-DNA Glycosidase, Viral Proteins
Added March 21, 2018
0 Communities
0 Members
1 Resources
12 MeSH Terms
The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
Mullins EA, Shi R, Parsons ZD, Yuen PK, David SS, Igarashi Y, Eichman BF
(2015) Nature 527: 254-8
MeSH Terms: Bacillus cereus, Base Pairing, Biocatalysis, Catalytic Domain, Crystallography, X-Ray, DNA Adducts, DNA Damage, DNA Glycosylases, DNA Repair, Duocarmycins, Indoles, Models, Molecular, Pyrroles
Added November 10, 2015
1 Communities
1 Members
0 Resources
13 MeSH Terms
Predicting near-UV electronic circular dichroism in nucleosomal DNA by means of DFT response theory.
Norman P, Parello J, Polavarapu PL, Linares M
(2015) Phys Chem Chem Phys 17: 21866-79
MeSH Terms: Base Pairing, Circular Dichroism, DNA, B-Form, Electrons, Models, Molecular, Nucleosides, Nucleosomes, Quantum Theory, Spectrophotometry, Ultraviolet, Thermodynamics
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
NMR analysis of base-pair opening kinetics in DNA.
Szulik MW, Voehler M, Stone MP
(2014) Curr Protoc Nucleic Acid Chem 59: 7.20.1-18
MeSH Terms: Base Pairing, DNA, Kinetics, Magnetic Resonance Spectroscopy
Added January 20, 2015
0 Communities
1 Members
0 Resources
4 MeSH Terms
Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates.
Goubau D, Schlee M, Deddouche S, Pruijssers AJ, Zillinger T, Goldeck M, Schuberth C, Van der Veen AG, Fujimura T, Rehwinkel J, Iskarpatyoti JA, Barchet W, Ludwig J, Dermody TS, Hartmann G, Reis e Sousa C
(2014) Nature 514: 372-375
MeSH Terms: Animals, Base Pairing, Base Sequence, DEAD Box Protein 58, DEAD-box RNA Helicases, Diphosphates, Female, Genome, Viral, Immunity, Innate, Male, Mice, RNA, Viral, Reoviridae
Added January 21, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
Looking for Waldo: a potential thermodynamic signature to DNA damage.
Gold B, Stone MP, Marky LA
(2014) Acc Chem Res 47: 1446-54
MeSH Terms: Base Pairing, Binding Sites, DNA, DNA Damage, DNA Glycosylases, DNA Repair, Kinetics, Nucleic Acid Conformation, Thermodynamics, Water
Added May 29, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Recognition of O6-benzyl-2'-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction.
Kowal EA, Lad RR, Pallan PS, Dhummakupt E, Wawrzak Z, Egli M, Sturla SJ, Stone MP
(2013) Nucleic Acids Res 41: 7566-76
MeSH Terms: Base Pairing, Base Sequence, DNA, Deoxyguanosine, Glycosylation, Guanine, Hydrogen Bonding, Models, Molecular, Nucleic Acid Conformation, Nucleosides, Thermodynamics, Thymine
Added March 7, 2014
0 Communities
2 Members
0 Resources
12 MeSH Terms
Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs.
Patra A, Harp J, Pallan PS, Zhao L, Abramov M, Herdewijn P, Egli M
(2013) Nucleic Acids Res 41: 2689-97
MeSH Terms: Adenine, Base Pairing, DNA, B-Form, Deoxyribonuclease EcoRI, Guanine, Models, Molecular, Ribonuclease H, Thermodynamics, Uracil
Added March 7, 2014
0 Communities
2 Members
0 Resources
9 MeSH Terms
The steric hypothesis for DNA replication and fluorine hydrogen bonding revisited in light of structural data.
Egli M
(2012) Acc Chem Res 45: 1237-46
MeSH Terms: Base Pairing, Base Sequence, DNA, DNA Replication, DNA-Directed DNA Polymerase, Fluorine, Humans, Hydrogen Bonding
Added May 27, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms