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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 11

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Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience.
Sanghani NS, Haase VH
(2019) Adv Chronic Kidney Dis 26: 253-266
MeSH Terms: Anemia, Barbiturates, Glycine, Humans, Isoquinolines, Picolinic Acids, Prolyl-Hydroxylase Inhibitors, Renal Insufficiency, Chronic, Treatment Outcome
Added March 24, 2020
0 Communities
1 Members
0 Resources
9 MeSH Terms
HIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism.
Haase VH
(2017) Hemodial Int 21 Suppl 1: S110-S124
MeSH Terms: Anemia, Barbiturates, Clinical Trials as Topic, Erythropoiesis, Erythropoietin, Glycine, Humans, Hypoxia-Inducible Factor-Proline Dioxygenases, Iron, Isoquinolines, Picolinic Acids, Prolyl-Hydroxylase Inhibitors, Renal Dialysis
Added April 28, 2017
0 Communities
1 Members
0 Resources
13 MeSH Terms
Targeting nucleophosmin 1 represents a rational strategy for radiation sensitization.
Sekhar KR, Benamar M, Venkateswaran A, Sasi S, Penthala NR, Crooks PA, Hann SR, Geng L, Balusu R, Abbas T, Freeman ML
(2014) Int J Radiat Oncol Biol Phys 89: 1106-1114
MeSH Terms: Animals, Barbiturates, Carcinoma, Non-Small-Cell Lung, DNA Breaks, Double-Stranded, DNA Repair, Fibroblasts, Histones, Humans, Indoles, Lung Neoplasms, Mice, Mice, Inbred C57BL, Mice, Nude, Molecular Targeted Therapy, Neoplasm Proteins, Nuclear Proteins, Nucleophosmin, Rad51 Recombinase, Radiation Tolerance, Radiation-Sensitizing Agents, Tissue Array Analysis, Tumor Cells, Cultured
Added January 20, 2015
0 Communities
1 Members
0 Resources
22 MeSH Terms
The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization.
Sekhar KR, Reddy YT, Reddy PN, Crooks PA, Venkateswaran A, McDonald WH, Geng L, Sasi S, Van Der Waal RP, Roti JL, Salleng KJ, Rachakonda G, Freeman ML
(2011) Clin Cancer Res 17: 6490-9
MeSH Terms: Animals, Barbiturates, Cell Line, Tumor, DNA Breaks, Double-Stranded, DNA Damage, DNA Repair, Humans, Indoles, Mice, Mice, Nude, Molecular Chaperones, Molecular Targeted Therapy, Neoplasms, Nuclear Proteins, Nucleophosmin, Radiation Tolerance, Radiation-Sensitizing Agents, Random Allocation
Added March 7, 2014
0 Communities
2 Members
0 Resources
18 MeSH Terms
Barbiturates require the N terminus and first transmembrane domain of the delta subunit for enhancement of alpha1beta3delta GABAA receptor currents.
Feng HJ, Macdonald RL
(2010) J Biol Chem 285: 23614-21
MeSH Terms: Allosteric Site, Barbiturates, Biophysics, Cell Line, DNA, Complementary, Humans, Ions, Patch-Clamp Techniques, Pentobarbital, Protein Structure, Tertiary, Receptors, GABA-A, Recombinant Proteins
Added January 24, 2015
0 Communities
1 Members
0 Resources
12 MeSH Terms
Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents.
Reddy YT, Sekhar KR, Sasi N, Reddy PN, Freeman ML, Crooks PA
(2010) Bioorg Med Chem Lett 20: 600-2
MeSH Terms: Antineoplastic Agents, Barbiturates, Benzene, HT29 Cells, Humans, Indoles, Pyrimidines, Radiation-Sensitizing Agents
Added March 5, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems.
Dostalek M, Hardy KD, Milne GL, Morrow JD, Chen C, Gonzalez FJ, Gu J, Ding X, Johnson DA, Johnson JA, Martin MV, Guengerich FP
(2008) J Biol Chem 283: 17147-57
MeSH Terms: Animals, Barbiturates, Cytochrome P-450 Enzyme System, Glutathione Peroxidase, Glutathione Reductase, Liver, Mice, Mice, Transgenic, Microsomes, Liver, Nicotinamide N-Methyltransferase, Nucleotides, Oxidative Stress, Pyridines, Rats, Reactive Oxygen Species
Added March 5, 2014
1 Communities
2 Members
0 Resources
15 MeSH Terms
In vivo oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers.
Dostalek M, Brooks JD, Hardy KD, Milne GL, Moore MM, Sharma S, Morrow JD, Guengerich FP
(2007) Mol Pharmacol 72: 1419-24
MeSH Terms: Animals, Barbiturates, Cytochrome P-450 Enzyme System, Enzyme Induction, Male, Oxidative Stress, Phenobarbital, Rats, Rats, Sprague-Dawley
Added March 5, 2014
1 Communities
2 Members
0 Resources
9 MeSH Terms
Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage.
Fortune JM, Osheroff N
(1998) J Biol Chem 273: 17643-50
MeSH Terms: Adenosine Triphosphate, Antigens, Neoplasm, Base Sequence, Catalysis, DNA, DNA Primers, DNA Topoisomerases, Type II, DNA-Binding Proteins, Enzyme Inhibitors, Humans, Hydrolysis, Isoenzymes, Protein Binding, Recombinant Proteins, Thiobarbiturates, Topoisomerase II Inhibitors
Added March 5, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
The induction of microsomal electron transport enzymes.
Waterman MR, Estabrook RW
(1983) Mol Cell Biochem 53-54: 267-78
MeSH Terms: Amino Acid Sequence, Animals, Barbiturates, Cloning, Molecular, Cytochrome P-450 Enzyme System, DNA, Hexobarbital, Microsomes, Microsomes, Liver, NADH, NADPH Oxidoreductases, NADPH Dehydrogenase, Protein Biosynthesis, RNA, Messenger, Sleep
Added February 12, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms