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Two-component system cross-regulation integrates Bacillus anthracis response to heme and cell envelope stress.
Mike LA, Choby JE, Brinkman PR, Olive LQ, Dutter BF, Ivan SJ, Gibbs CM, Sulikowski GA, Stauff DL, Skaar EP
(2014) PLoS Pathog 10: e1004044
MeSH Terms: Bacillus anthracis, Bacterial Proteins, Cell Wall, Gene Expression Regulation, Bacterial, Heme, Membrane Transport Proteins, Signal Transduction, Stress, Physiological
Added May 27, 2014
0 Communities
1 Members
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8 MeSH Terms
Delineating the effect of host environmental signals on a fully virulent strain of Bacillus anthracis using an integrated transcriptomics and proteomics approach.
Panda G, Basak T, Tanwer P, Sengupta S, dos Santos VA, Bhatnagar R
(2014) J Proteomics 105: 242-65
MeSH Terms: Bacillus anthracis, Bacterial Proteins, Gene Expression Profiling, Proteome, Proteomics, Signal Transduction, Transcriptome
Added November 3, 2017
0 Communities
1 Members
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7 MeSH Terms
Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.
Aldred KJ, Schwanz HA, Li G, McPherson SA, Turnbough CL, Kerns RJ, Osheroff N
(2013) ACS Chem Biol 8: 2660-8
MeSH Terms: Anti-Bacterial Agents, Antigens, Neoplasm, Bacillus anthracis, Cations, Divalent, DNA Cleavage, DNA Topoisomerase IV, DNA Topoisomerases, Type II, DNA, Bacterial, DNA-Binding Proteins, Drug Resistance, Bacterial, Humans, Kinetics, Magnesium, Mutation, Quinazolinones, Quinolones, Recombinant Proteins, Species Specificity, Structure-Activity Relationship, Water
Added March 7, 2014
0 Communities
1 Members
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20 MeSH Terms
Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance.
Aldred KJ, McPherson SA, Turnbough CL, Kerns RJ, Osheroff N
(2013) Nucleic Acids Res 41: 4628-39
MeSH Terms: Anti-Bacterial Agents, Bacillus anthracis, Cations, Divalent, Ciprofloxacin, DNA, DNA Cleavage, DNA Topoisomerase IV, Drug Resistance, Magnesium, Metals, Mutation, Quinazolinones, Quinolones, Water
Added March 7, 2014
0 Communities
1 Members
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14 MeSH Terms
Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance.
Aldred KJ, McPherson SA, Wang P, Kerns RJ, Graves DE, Turnbough CL, Osheroff N
(2012) Biochemistry 51: 370-81
MeSH Terms: Bacillus anthracis, DNA Gyrase, DNA Topoisomerase IV, Drug Interactions, Drug Resistance, Bacterial, Mutagenesis, Site-Directed, Quinolones
Added March 7, 2014
0 Communities
1 Members
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7 MeSH Terms
Entry of Bacillus anthracis spores into epithelial cells is mediated by the spore surface protein BclA, integrin α2β1 and complement component C1q.
Xue Q, Gu C, Rivera J, Höök M, Chen X, Pozzi A, Xu Y
(2011) Cell Microbiol 13: 620-34
MeSH Terms: Animals, Anthrax, Bacillus anthracis, Bacterial Adhesion, CHO Cells, Cell Line, Complement C1q, Cricetinae, Cricetulus, Endocytosis, Epithelial Cells, Humans, Integrin alpha2beta1, Membrane Glycoproteins, Mice, Skin Diseases, Bacterial, Spores, Bacterial
Added February 24, 2014
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17 MeSH Terms
Intrinsic curvature associated with the coordinately regulated anthrax toxin gene promoters.
Hadjifrangiskou M, Koehler TM
(2008) Microbiology (Reading) 154: 2501-2512
MeSH Terms: Antigens, Bacterial, Bacillus anthracis, Bacterial Proteins, Bacterial Toxins, Base Sequence, Gene Expression Regulation, Bacterial, Molecular Sequence Data, Nucleic Acid Conformation, Promoter Regions, Genetic, Sequence Alignment, Sequence Deletion, Trans-Activators
Added August 6, 2014
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1 Members
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12 MeSH Terms
Anthrax toxin receptor 2 determinants that dictate the pH threshold of toxin pore formation.
Scobie HM, Marlett JM, Rainey GJ, Lacy DB, Collier RJ, Young JA
(2007) PLoS One 2: e329
MeSH Terms: Amino Acid Sequence, Animals, Anthrax, Antigens, Bacterial, Bacillus anthracis, Bacterial Proteins, Conserved Sequence, DNA Primers, DNA, Bacterial, Endocytosis, Genes, Reporter, Hydrogen-Ion Concentration, Membrane Proteins, Mutagenesis, Plasmids, Receptors, Peptide
Added May 7, 2013
0 Communities
1 Members
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16 MeSH Terms
The alternative sigma factor sigmaH is required for toxin gene expression by Bacillus anthracis.
Hadjifrangiskou M, Chen Y, Koehler TM
(2007) J Bacteriol 189: 1874-83
MeSH Terms: Amino Acid Sequence, Antigens, Bacterial, Bacillus anthracis, Bacterial Proteins, Bacterial Toxins, Gene Expression Regulation, Bacterial, Molecular Sequence Data, Phenotype, Promoter Regions, Genetic, Sigma Factor, Trans-Activators
Added August 6, 2014
0 Communities
1 Members
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11 MeSH Terms
Anthrax toxin receptor 2-dependent lethal toxin killing in vivo.
Scobie HM, Wigelsworth DJ, Marlett JM, Thomas D, Rainey GJ, Lacy DB, Manchester M, Collier RJ, Young JA
(2006) PLoS Pathog 2: e111
MeSH Terms: Animals, Anthrax, Antibodies, Bacterial, Antigens, Bacterial, Bacillus anthracis, Bacterial Toxins, Base Sequence, Humans, Longevity, Male, Membrane Proteins, Microfilament Proteins, Molecular Sequence Data, Neoplasm Proteins, Rats, Rats, Inbred F344, Receptors, Cell Surface, Receptors, Peptide
Added May 7, 2013
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1 Members
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18 MeSH Terms