DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer.
Luo N, Nixon MJ, Gonzalez-Ericsson PI, Sanchez V, Opalenik SR, Li H, Zahnow CA, Nickels ML, Liu F, Tantawy MN, Sanders ME, Manning HC, Balko JM
(2018) Nat Commun 9
: 248MeSH Terms: Animals, Antineoplastic Agents, Azacitidine, Breast Neoplasms, Cell Line, Tumor, DNA (Cytosine-5-)-Methyltransferase 1, Female, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Genes, MHC Class I, Humans, Mammary Neoplasms, Experimental, Mice, Promoter Regions, Genetic, T-Lymphocytes, CytotoxicAdded March 14, 2018
15 MeSH Terms
KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine.
Stewart ML, Tamayo P, Wilson AJ, Wang S, Chang YM, Kim JW, Khabele D, Shamji AF, Schreiber SL
(2015) Cancer Res 75
: 2897-906MeSH Terms: Animals, Azacitidine, Biomarkers, Tumor, Cystadenocarcinoma, Serous, Decitabine, Drug Resistance, Neoplasm, Female, Genes, ras, Humans, Mice, Mice, Nude, Mice, Transgenic, Mutation, Ovarian Neoplasms, Prognosis, Tumor Cells, Cultured, Xenograft Model Antitumor AssaysAdded February 22, 2016
17 MeSH Terms
Gastric cancer prevention by demethylation.
Schneider BG, Peek RM
(2013) Cancer Prev Res (Phila) 6
: 253-6MeSH Terms: Adenocarcinoma, Animals, Azacitidine, DNA-Cytosine Methylases, Decitabine, Helicobacter Infections, Helicobacter pylori, Male, Stomach NeoplasmsAdded September 3, 2013
9 MeSH Terms
Evaluation of long-term transgene expression in piggyBac-modified human T lymphocytes.
Nakazawa Y, Saha S, Galvan DL, Huye L, Rollins L, Rooney CM, Wilson MH
(2013) J Immunother 36
: 3-10MeSH Terms: Antineoplastic Agents, Azacitidine, Cells, Cultured, Cytokines, DNA Transposable Elements, Gene Expression, Green Fluorescent Proteins, Histone Deacetylase Inhibitors, Humans, Hydroxamic Acids, Leukocytes, Mononuclear, Nerve Tissue Proteins, Receptors, Antigen, T-Cell, T-Lymphocytes, Transfection, TransgenesAdded August 22, 2013
16 MeSH Terms
Silencing of glutathione peroxidase 3 through DNA hypermethylation is associated with lymph node metastasis in gastric carcinomas.
Peng DF, Hu TL, Schneider BG, Chen Z, Xu ZK, El-Rifai W
(2012) PLoS One 7
: e46214MeSH Terms: Azacitidine, Case-Control Studies, Cell Line, Tumor, DNA Methylation, Decitabine, Fluorescent Antibody Technique, Gene Expression Regulation, Enzymologic, Gene Silencing, Glutathione Peroxidase, Humans, Lymphatic Metastasis, Promoter Regions, Genetic, RNA, Messenger, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Stomach NeoplasmsAdded March 5, 2014
16 MeSH Terms
Methylation-dependent activation of CDX1 through NF-κB: a link from inflammation to intestinal metaplasia in the human stomach.
Rau TT, Rogler A, Frischauf M, Jung A, Konturek PC, Dimmler A, Faller G, Sehnert B, El-Rifai W, Hartmann A, Voll RE, Schneider-Stock R
(2012) Am J Pathol 181
: 487-98MeSH Terms: Adult, Aged, Aged, 80 and over, Azacitidine, Base Sequence, Chromatin, Conserved Sequence, CpG Islands, DNA Methylation, Female, Gastric Mucosa, Gastritis, Gene Expression Regulation, Neoplastic, Homeodomain Proteins, Humans, Inflammation, Intestinal Mucosa, Intestines, Male, Metaplasia, Middle Aged, Molecular Sequence Data, NF-kappa B, Promoter Regions, Genetic, Protein Binding, Stomach, Stomach Neoplasms, Tumor Necrosis Factor-alpha, Young AdultAdded September 3, 2013
29 MeSH Terms
Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.
Martínez-López N, García-Rodríguez JL, Varela-Rey M, Gutiérrez V, Fernández-Ramos D, Beraza N, Aransay AM, Schlangen K, Lozano JJ, Aspichueta P, Luka Z, Wagner C, Evert M, Calvisi DF, Lu SC, Mato JM, Martínez-Chantar ML
(2012) Gastroenterology 143
: 787-798.e13MeSH Terms: AMP-Activated Protein Kinases, Animals, Apoptosis, Azacitidine, Calcium-Calmodulin-Dependent Protein Kinase Kinase, Carcinoma, Hepatocellular, Cell Line, Tumor, Cell Proliferation, Cell Transformation, Neoplastic, Cyclic AMP-Dependent Protein Kinases, DNA Methylation, Enzyme Activation, Enzyme Inhibitors, Glycine N-Methyltransferase, Guanine Nucleotide Exchange Factors, Humans, Liver Neoplasms, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Nude, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase Kinases, Phosphorylation, Protein Serine-Threonine Kinases, RNA Interference, Ribosomal Protein S6 Kinases, 90-kDa, Signal Transduction, Time Factors, Transfection, Tumor Burden, ras Guanine Nucleotide Exchange Factors, ras ProteinsAdded January 20, 2015
33 MeSH Terms
Location-specific epigenetic regulation of the metallothionein 3 gene in esophageal adenocarcinomas.
Peng D, Hu TL, Jiang A, Washington MK, Moskaluk CA, Schneider-Stock R, El-Rifai W
(2011) PLoS One 6
: e22009MeSH Terms: Adenocarcinoma, Adult, Aged, Aged, 80 and over, Azacitidine, Cell Line, Tumor, CpG Islands, DNA Methylation, Down-Regulation, Epigenesis, Genetic, Esophageal Neoplasms, Gene Expression Regulation, Neoplastic, Genes, Neoplasm, Histones, Humans, Lymphatic Metastasis, Metallothionein 3, Middle Aged, Neoplasm Staging, Nerve Tissue Proteins, Promoter Regions, Genetic, Protein Processing, Post-Translational, Repressor ProteinsAdded July 26, 2012
23 MeSH Terms
CpG methylation at the USF-binding site mediates cell-specific transcription of human ascorbate transporter SVCT2 exon 1a.
Qiao H, May JM
(2011) Biochem J 440
: 73-84MeSH Terms: Azacitidine, CCAAT-Binding Factor, Cell Line, Cell Line, Tumor, CpG Islands, Decitabine, Dinucleoside Phosphates, Exons, Humans, Methylation, Promoter Regions, Genetic, Sodium-Coupled Vitamin C Transporters, Upstream Stimulatory FactorsAdded December 5, 2013
13 MeSH Terms
Epigenetic silencing of somatostatin in gastric cancer.
Jackson K, Soutto M, Peng D, Hu T, Marshal D, El-Rifai W
(2011) Dig Dis Sci 56
: 125-30MeSH Terms: Adenocarcinoma, Antineoplastic Agents, Azacitidine, Biomarkers, Tumor, Cell Line, Tumor, DNA Methylation, Decitabine, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Humans, Hydroxamic Acids, Methylation, Predictive Value of Tests, RNA, Messenger, Reproducibility of Results, Somatostatin, Stomach NeoplasmsAdded July 26, 2012
17 MeSH Terms