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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 15

Publication Record

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Connecting the Dots: Therapy-Induced Senescence and a Tumor-Suppressive Immune Microenvironment.
Vilgelm AE, Johnson CA, Prasad N, Yang J, Chen SC, Ayers GD, Pawlikowski JS, Raman D, Sosman JA, Kelley M, Ecsedy JA, Shyr Y, Levy SE, Richmond A
(2016) J Natl Cancer Inst 108: djv406
MeSH Terms: Animals, Aurora Kinase A, Cell Line, Tumor, Cellular Senescence, Chemokine CCL5, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, Gene Expression Regulation, Neoplastic, Heterografts, Humans, Immunocompetence, Immunocompromised Host, Immunotherapy, Lymphocyte Activation, Lymphocytes, Tumor-Infiltrating, Melanoma, Mice, Real-Time Polymerase Chain Reaction, Skin Neoplasms, Transcriptome, Tumor Microenvironment, Tumor Necrosis Factor Receptor Superfamily, Member 9
Added January 18, 2016
2 Communities
3 Members
0 Resources
25 MeSH Terms
Aurora kinase A in gastrointestinal cancers: time to target.
Katsha A, Belkhiri A, Goff L, El-Rifai W
(2015) Mol Cancer 14: 106
MeSH Terms: Animals, Aurora Kinase A, Clinical Trials as Topic, Gastrointestinal Neoplasms, Humans, Molecular Targeted Therapy, Protein Kinase Inhibitors, Signal Transduction
Added September 28, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms
Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells.
Vilgelm AE, Pawlikowski JS, Liu Y, Hawkins OE, Davis TA, Smith J, Weller KP, Horton LW, McClain CM, Ayers GD, Turner DC, Essaka DC, Stewart CF, Sosman JA, Kelley MC, Ecsedy JA, Johnston JN, Richmond A
(2015) Cancer Res 75: 181-93
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Aurora Kinase A, Azepines, Cell Proliferation, Humans, Imidazoles, Melanoma, Melanoma, Experimental, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Nude, Piperazines, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-mdm2, Pyrimidines
Added January 20, 2015
2 Communities
4 Members
0 Resources
17 MeSH Terms
AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers.
Katsha A, Arras J, Soutto M, Belkhiri A, El-Rifai W
(2014) Mol Oncol 8: 1419-28
MeSH Terms: Aurora Kinase A, Blotting, Western, Cell Line, Tumor, Cell Survival, Esophageal Neoplasms, Fluorescent Antibody Technique, Humans, Janus Kinase 2, RNA, Small Interfering, STAT3 Transcription Factor, Stomach Neoplasms
Added February 19, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
HDM2 regulation by AURKA promotes cell survival in gastric cancer.
Sehdev V, Katsha A, Arras J, Peng D, Soutto M, Ecsedy J, Zaika A, Belkhiri A, El-Rifai W
(2014) Clin Cancer Res 20: 76-86
MeSH Terms: Adenocarcinoma, Animals, Antineoplastic Agents, Aurora Kinase A, Azepines, Cell Line, Tumor, Cell Survival, Female, Humans, Mice, Mice, Nude, Phosphorylation, Proteolysis, Proto-Oncogene Proteins c-mdm2, Pyrimidines, Stomach Neoplasms, Tumor Suppressor Protein p53, Ubiquitination, Up-Regulation, Xenograft Model Antitumor Assays
Added March 5, 2014
0 Communities
2 Members
0 Resources
20 MeSH Terms
Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia.
Katsha A, Soutto M, Sehdev V, Peng D, Washington MK, Piazuelo MB, Tantawy MN, Manning HC, Lu P, Shyr Y, Ecsedy J, Belkhiri A, El-Rifai W
(2013) Gastroenterology 145: 1312-22.e1-8
MeSH Terms: Adenocarcinoma, Animals, Aurora Kinase A, Azepines, Carcinogenesis, Cell Line, Tumor, Disease Models, Animal, Female, Gastric Mucosa, Heterografts, Humans, In Vitro Techniques, Inflammation, Mice, Knockout, Mice, Nude, NF-kappa B, Peptides, Phosphorylation, Protein Kinase Inhibitors, Pyrimidines, Stomach Neoplasms, Trefoil Factor-1, Up-Regulation
Added September 3, 2013
1 Communities
6 Members
0 Resources
23 MeSH Terms
The combination of alisertib, an investigational Aurora kinase A inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas.
Sehdev V, Katsha A, Ecsedy J, Zaika A, Belkhiri A, El-Rifai W
(2013) Cancer 119: 904-14
MeSH Terms: Adenocarcinoma, Animals, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Aurora Kinase A, Aurora Kinases, Azepines, Cell Cycle Checkpoints, Cell Survival, Docetaxel, Female, Gastrointestinal Neoplasms, Humans, Mice, Mice, Nude, Polyploidy, Protein Kinase Inhibitors, Protein-Serine-Threonine Kinases, Pyrimidines, Taxoids, Xenograft Model Antitumor Assays
Added September 3, 2013
0 Communities
3 Members
0 Resources
21 MeSH Terms
The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells.
Sehdev V, Peng D, Soutto M, Washington MK, Revetta F, Ecsedy J, Zaika A, Rau TT, Schneider-Stock R, Belkhiri A, El-Rifai W
(2012) Mol Cancer Ther 11: 763-74
MeSH Terms: Adenocarcinoma, Animals, Antineoplastic Agents, Apoptosis, Apoptosis Regulatory Proteins, Aurora Kinase A, Aurora Kinases, Azepines, Blotting, Western, Cell Cycle Checkpoints, Cell Line, Cell Line, Tumor, Cell Survival, Cisplatin, Drug Synergism, Esophageal Neoplasms, Esophagus, Female, Gene Expression, Humans, Mice, Mice, Nude, Phosphorylation, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, Pyrimidines, Reverse Transcriptase Polymerase Chain Reaction, Xenograft Model Antitumor Assays
Added September 3, 2013
1 Communities
4 Members
0 Resources
29 MeSH Terms
Conditional ablation of Ikkb inhibits melanoma tumor development in mice.
Yang J, Splittgerber R, Yull FE, Kantrow S, Ayers GD, Karin M, Richmond A
(2010) J Clin Invest 120: 2563-74
MeSH Terms: Animals, Apoptosis, Aurora Kinase A, Aurora Kinase B, Aurora Kinases, Cyclin-Dependent Kinase 2, Cyclin-Dependent Kinase 4, Genes, ras, I-kappa B Kinase, Melanocytes, Melanoma, Mice, Mice, Knockout, Mice, Transgenic, NF-kappa B, Neoplasms, Phosphorylation, Protein-Serine-Threonine Kinases, Transcription Factor RelA, Transcription, Genetic, Tumor Suppressor Protein p53
Added June 14, 2013
3 Communities
3 Members
0 Resources
21 MeSH Terms
Aurora kinase inhibitors--rising stars in cancer therapeutics?
Dar AA, Goff LW, Majid S, Berlin J, El-Rifai W
(2010) Mol Cancer Ther 9: 268-78
MeSH Terms: Antineoplastic Agents, Aurora Kinase A, Aurora Kinases, Clinical Trials as Topic, Enzyme Inhibitors, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Humans, Models, Biological, Neoplasms, Protein-Serine-Threonine Kinases, Signal Transduction
Added March 11, 2014
0 Communities
3 Members
0 Resources
12 MeSH Terms