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Modified sites and functional consequences of 4-oxo-2-nonenal adducts in HDL that are elevated in familial hypercholesterolemia.
May-Zhang LS, Yermalitsky V, Melchior JT, Morris J, Tallman KA, Borja MS, Pleasent T, Amarnath V, Song W, Yancey PG, Davidson WS, Linton MF, Davies SS
(2019) J Biol Chem 294: 19022-19033
MeSH Terms: Aldehydes, Animals, Apolipoprotein A-I, Atherosclerosis, Cells, Cultured, Female, Humans, Hyperlipoproteinemia Type II, Lipoproteins, HDL, Lysine, Male, Mice, Mice, Inbred C57BL, Mice, Knockout
Show Abstract · Added November 13, 2019
The lipid aldehyde 4-oxo-2-nonenal (ONE) is a highly reactive protein crosslinker derived from peroxidation of n-6 polyunsaturated fatty acids and generated together with 4-hydroxynonenal (HNE). Lipid peroxidation product-mediated crosslinking of proteins in high-density lipoprotein (HDL) causes HDL dysfunction and contributes to atherogenesis. Although HNE is relatively well-studied, the role of ONE in atherosclerosis and in modifying HDL is unknown. Here, we found that individuals with familial hypercholesterolemia (FH) had significantly higher ONE-ketoamide (lysine) adducts in HDL (54.6 ± 33.8 pmol/mg) than healthy controls (15.3 ± 5.6 pmol/mg). ONE crosslinked apolipoprotein A-I (apoA-I) on HDL at a concentration of > 3 mol ONE per 10 mol apoA-I (0.3 eq), which was 100-fold lower than HNE, but comparable to the potent protein crosslinker isolevuglandin. ONE-modified HDL partially inhibited HDL's ability to protect against lipopolysaccharide (LPS)-induced tumor necrosis factor α (TNFα) and interleukin-1β (IL-1β) gene expression in murine macrophages. At 3 eq, ONE dramatically decreased apoA-I exchange from HDL, from ∼46.5 to ∼18.4% ( < 0.001). Surprisingly, ONE modification of HDL or apoA-I did not alter macrophage cholesterol efflux capacity. LC-MS/MS analysis revealed that Lys-12, Lys-23, Lys-96, and Lys-226 in apoA-I are modified by ONE ketoamide adducts. Compared with other dicarbonyl scavengers, pentylpyridoxamine (PPM) most efficaciously blocked ONE-induced protein crosslinking in HDL and also prevented HDL dysfunction in an model of inflammation. Our findings show that ONE-HDL adducts cause HDL dysfunction and are elevated in individuals with FH who have severe hypercholesterolemia.
© 2019 May-Zhang et al.
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14 MeSH Terms
Left Ventricular Mass at MRI and Long-term Risk of Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis (MESA).
Kawel-Boehm N, Kronmal R, Eng J, Folsom A, Burke G, Carr JJ, Shea S, Lima JAC, Bluemke DA
(2019) Radiology 293: 107-114
MeSH Terms: Aged, Aged, 80 and over, Atherosclerosis, Cohort Studies, Comorbidity, Ethnic Groups, Female, Heart Failure, Heart Ventricles, Humans, Hypertrophy, Left Ventricular, Magnetic Resonance Imaging, Male, Middle Aged, Myocardial Infarction, Prospective Studies, Risk, Risk Factors, United States
Show Abstract · Added January 10, 2020
Background Few data exist on the long-term risk prediction of elevated left ventricular (LV) mass quantified by MRI for cardiovascular (CV) events in a contemporary, ethnically diverse cohort. Purpose To assess the long-term impact of elevated LV mass on CV events in a prospective cohort study of a multiethnic population in relationship to risk factors and coronary artery calcium (CAC) score. Materials and Methods The Multi-Ethnic Study of Atherosclerosis, or MESA (: NCT00005487), is an ongoing prospective multicenter population-based study in the United States. A total of 6814 participants (age range, 45-84 years) free of clinical CV disease at baseline were enrolled between 2000 and 2002. In 4988 participants (2613 [52.4%] women; mean age, 62 years ± 10.1 [standard deviation]) followed over 15 years for CV events, LV mass was derived from cardiac MRI at baseline enrollment by using semiautomated software at a central core laboratory. Cox proportional hazard models, Kaplan-Meier curves, and scores were applied to assess the impact of LV hypertrophy. Results A total of 290 participants had hard coronary heart disease (CHD) events (207 myocardial infarctions [MIs], 95 CHD deaths), 57 had other CV disease-related deaths, and 215 had heart failure (HF). LV hypertrophy was an independent predictor of hard CHD events (hazard ratio [HR]: 2.7; 95% confidence interval [CI]: 1.9, 3.8), MI (HR: 2.8; 95% CI: 1.8, 4.0), CHD death (HR: 4.3; 95% CI: 2.5, 7.3), other CV death (HR: 7.5; 95% CI: 4.2, 13.5), and HF (HR: 5.4; 95% CI: 3.8, 7.5) ( < .001 for all end points). LV hypertrophy was a stronger predictor than CAC for CHD death, other CV death, and HF ( scores: 5.4 vs 3.4, 6.8 vs 2.4, and 9.7 vs 3.2 for LV hypertrophy vs CAC, respectively). Kaplan-Meier analysis demonstrated an increased risk of CV events in participants with LV hypertrophy, particularly after 5 years. Conclusion Elevated left ventricular mass was strongly associated with hard coronary heart disease events, other cardiovascular death, and heart failure over 15 years of follow-up, independent of traditional risk factors and coronary artery calcium score. © RSNA, 2019 See also the editorial by Hanneman in this issue.
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19 MeSH Terms
Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis.
Linton MF, Moslehi JJ, Babaev VR
(2019) Int J Mol Sci 20:
MeSH Terms: Animals, Apoptosis, Atherosclerosis, Blood Cells, Cell Survival, Humans, Macrophage Activation, Macrophages, Phosphatidylinositol 3-Kinases, Protein Isoforms, Proto-Oncogene Proteins c-akt, Signal Transduction
Show Abstract · Added November 12, 2019
The PI3K/Akt pathway plays a crucial role in the survival, proliferation, and migration of macrophages, which may impact the development of atherosclerosis. Changes in Akt isoforms or modulation of the Akt activity levels in macrophages significantly affect their polarization phenotype and consequently atherosclerosis in mice. Moreover, the activity levels of Akt signaling determine the viability of monocytes/macrophages and their resistance to pro-apoptotic stimuli in atherosclerotic lesions. Therefore, elimination of pro-apoptotic factors as well as factors that antagonize or suppress Akt signaling in macrophages increases cell viability, protecting them from apoptosis, and this markedly accelerates atherosclerosis in mice. In contrast, inhibition of Akt signaling by the ablation of Rictor in myeloid cells, which disrupts mTORC2 assembly, significantly decreases the viability and proliferation of blood monocytes and macrophages with the suppression of atherosclerosis. In addition, monocytes and macrophages exhibit a threshold effect for Akt protein levels in their ability to survive. Ablation of two Akt isoforms, preserving only a single Akt isoform in myeloid cells, markedly compromises monocyte and macrophage viability, inducing monocytopenia and diminishing early atherosclerosis. These recent advances in our understanding of Akt signaling in macrophages in atherosclerosis may have significant relevance in the burgeoning field of cardio-oncology, where PI3K/Akt inhibitors being tested in cancer patients can have significant cardiovascular and metabolic ramifications.
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NT-proBNP, race and endothelial function in the Multi-Ethnic Study of Atherosclerosis.
Yang S, Huang S, Daniels LB, Yeboah J, Lima JAC, Cannone V, Burnett JC, Beckman JA, Carr JJ, Wang TJ, Gupta DK
(2019) Heart 105: 1590-1596
MeSH Terms: African Americans, Asian Americans, Atherosclerosis, Cross-Sectional Studies, Endothelium, Vascular, Female, Humans, Male, Middle Aged, Natriuretic Peptide, Brain, Peptide Fragments, Risk Factors, United States, Vasodilation
Show Abstract · Added January 10, 2020
OBJECTIVE - Natriuretic peptides (NPs) are hormones with cardioprotective effects. NP levels vary by race; however, the pathophysiological consequences of lower NP levels are not well understood. We aimed to quantify the association between NPs and endothelial function as measured by flow-mediated dilation (FMD) and the contribution of NP levels to racial differences in endothelial function.
METHODS - In this cross-sectional study of 2938 Multi-Ethnic Study of Atherosclerosis participants (34% Caucasian, 20% African-American, 20% Asian-American and 26% Hispanic) without cardiovascular disease at baseline, multivariable linear regression models were used to examine the association between serum N-terminal pro-B-type NP (NT-proBNP) and natural log-transformed FMD. We also tested whether NT-proBNP mediated the relationship between race and FMD using the product of coefficients method.
RESULTS - Among African-American and Chinese-American individuals, lower NT-proBNP levels were associated with lower FMD, β=0.06 (95% CI: 0.03 to 0.09; p<0.001) and β=0.06 (95% CI: 0.02 to 0.09; p=0.002), respectively. Non-significant associations between NT-proBNP and FMD were found in Hispanic and Caucasian individuals. In multivariable models, endothelial function differed by race, with African-American individuals having the lowest FMD compared with Caucasians, p<0.001. Racial differences in FMD among African-Americans and Chinese-Americans were mediated in part by NT-proBNP levels (African-Americans, mediation effect: -0.03(95% CI: -0.05 to -0.01); Chinese-Americans, mediation effect: -0.03(95% CI: -0.05 to -0.01)).
CONCLUSIONS - Lower NP levels are associated with worse endothelial function among African-Americans and Chinese-Americans. A relative NP deficiency in some racial/ethnic groups may contribute to differences in vascular function.
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
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14 MeSH Terms
FcγRIIb on CD11c cells modulates serum cholesterol and triglyceride levels and differentially affects atherosclerosis in male and female Ldlr mice.
Marvin J, Rhoads JP, Major AS
(2019) Atherosclerosis 285: 108-119
MeSH Terms: Animals, Atherosclerosis, CD11 Antigens, Cholesterol, Dendritic Cells, Female, Male, Mice, Mice, Inbred C57BL, Receptors, IgG, Sex Factors, Triglycerides
Show Abstract · Added March 30, 2020
BACKGROUND AND AIMS - Circulating levels of oxidized lipoprotein (oxLDL) correlate with myocardial infarction risk and atherosclerosis severity. Our previous study demonstrates that oxLDL immune complexes (oxLDL-ICs) can signal through FcγRs on bone marrow-derived dendritic cells (BMDCs) and enhance their activation and inflammatory cytokine secretion. While global FcγR studies have shown that activating FcγRs are proatherogenic, the role of the inhibitory FcγRIIb is unclear. We sought to determine the role of DC-specific FcγRIIb in atherosclerosis.
METHODS - Bone marrow chimeras were generated by rescuing lethally irradiated Ldlr mice with hematopoietic cells from littermate CD11c-Cre or CD11c-CreFcgr2b donors. Four weeks following transplant, recipients were placed on a Western diet for eight weeks. Various tissues and organs were analyzed for differences in inflammation.
RESULTS - Quantitation of atherosclerosis in the proximal aorta demonstrated a 58% increase in female CD11c-CreFcgr2b recipients, but a surprising 44% decrease in male recipients. Hepatic cholesterol and triglycerides were increased in female CD11c-CreFcgr2b recipients. This was associated with an increase in CD36 and MHC Class II expression on hepatic CD11cCD11b DCs in female livers. In contrast, male CD11c-CreFcgr2b recipients had decreased hepatic lipids with a corresponding decrease in CD36 and MHC Class II expression on CD11c cells. Interestingly, both sexes of CD11c-CreFcgr2b recipients had significant decreases in serum cholesterol and TGs with corresponding decreases in liver Fasn transcripts.
CONCLUSIONS - The absence of FcγRIIb expression on CD11c cells results in sex-dependent alteration in liver inflammation influencing atherogenesis and sex-independent modulation of serum cholesterol and TGs.
Published by Elsevier B.V.
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How Oxidized Low-Density Lipoprotein Activates Inflammatory Responses.
Rhoads JP, Major AS
(2018) Crit Rev Immunol 38: 333-342
MeSH Terms: Animals, Atherosclerosis, Humans, Inflammation, Lipoproteins, LDL
Show Abstract · Added March 30, 2020
Cardiovascular disease (CVD) is the number one cause of death in the United States and worldwide. The most common cause of cardiovascular disease is atherosclerosis, or formation of fatty plaques in the arteries. Low-density lipoprotein (LDL), termed "bad cholesterol", is a large molecule comprised of many proteins as well as lipids including cholesterol, phospholipids, and triglycerides. Circulating levels of LDL are directly associated with atherosclerosis disease severity. Once thought to simply be caused by passive retention of LDL in the vasculature, atherosclerosis studies over the past 40-50 years have uncovered a much more complex mechanism. It has now become well established that within the vasculature, LDL can undergo many different types of oxidative modifications such as esterification and lipid peroxidation. The resulting oxidized LDL (oxLDL) has been found to have antigenic potential and contribute heavily to atherosclerosis associated inflammation, activating both innate and adaptive immunity. This review discusses the many proposed mechanisms by which oxidized LDL modulates inflammatory responses and how this might modulate atherosclerosis.
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Body Composition and Diabetes Risk in South Asians: Findings From the MASALA and MESA Studies.
Flowers E, Lin F, Kandula NR, Allison M, Carr JJ, Ding J, Shah R, Liu K, Herrington D, Kanaya AM
(2019) Diabetes Care 42: 946-953
MeSH Terms: Aged, Asia, Asian Americans, Atherosclerosis, Body Composition, Cohort Studies, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Prediabetic State, Prevalence, Risk Factors, United States
Show Abstract · Added January 10, 2020
OBJECTIVE - South Asians have a higher prevalence of type 2 diabetes compared with other race/ethnic groups. Body composition is associated with the risk for type 2 diabetes. Differences in body composition between South Asians and other race/ethnic groups are one hypothesized mechanism to explain the disproportionate prevalence of type 2 diabetes in this population.
RESEARCH DESIGN AND METHODS - This study used data from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) and the Multi-Ethnic Study of Atherosclerosis (MESA) cohorts to determine whether body composition mediated the elevated prevalence of impaired fasting glucose and type 2 diabetes in South Asians. Participants ( = 2,615) with complete body composition data were included. Ordinal logistic regression models were calculated to determine the odds for glycemic impairment in South Asians compared with the MESA cohort.
RESULTS - In multivariate models, South Asians had a significantly higher prevalence of glycemic impairment and type 2 diabetes compared with all four race/ethnic groups included in the MESA ( < 0.001 for all). In unadjusted and multivariate adjusted models, South Asians had higher odds for impaired fasting glucose and type 2 diabetes compared with all other race/ethnic groups ( < 0.001 for all). The addition of body composition measures did not significantly mitigate this relationship.
CONCLUSIONS - We did not identify strong evidence that accounting for body composition explains differences in the risk for type 2 diabetes. Future prospective studies of the MESA and MASALA cohorts are needed to understand how adipose tissue impacts the risk for type 2 diabetes and how to best assess this risk.
© 2019 by the American Diabetes Association.
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16 MeSH Terms
Dual inhibition of endothelial miR-92a-3p and miR-489-3p reduces renal injury-associated atherosclerosis.
Wiese CB, Zhong J, Xu ZQ, Zhang Y, Ramirez Solano MA, Zhu W, Linton MF, Sheng Q, Kon V, Vickers KC
(2019) Atherosclerosis 282: 121-131
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Aorta, Atherosclerosis, Cell Line, Disease Models, Animal, Endothelium, Vascular, Female, Gene Expression Regulation, HEK293 Cells, Humans, Kidney Diseases, Mice, Mice, Knockout, ApoE, MicroRNAs, Nephrectomy, Nuclear Proteins, Phenotype, Phosphorylation, RNA, Small Interfering, STAT3 Transcription Factor, Signal Transduction, Transcriptome, Transforming Growth Factor beta
Show Abstract · Added April 10, 2019
BACKGROUND AND AIMS - Cardiovascular disease (CVD) is the leading cause of death in chronic kidney disease (CKD) patients, however, the underlying mechanisms that link CKD and CVD are not fully understood and limited treatment options exist in this high-risk population. microRNAs (miRNA) are critical regulators of gene expression for many biological processes in atherosclerosis, including endothelial dysfunction and inflammation. We hypothesized that renal injury-induced endothelial miRNAs promote atherosclerosis. Here, we demonstrate that dual inhibition of endothelial miRNAs inhibits atherosclerosis in the setting of renal injury.
METHODS - Aortic endothelial miRNAs were analyzed in apolipoprotein E-deficient (Apoe) mice with renal damage (5/6 nephrectomy, 5/6Nx) by real-time PCR. Endothelial miR-92a-3p and miR-489-3p were inhibited by locked-nucleic acid (LNA) miRNA inhibitors complexed to HDL.
RESULTS - Renal injury significantly increased endothelial miR-92a-3p levels in Apoe;5/6Nx mice. Dual inhibition of miR-92a-3p and miR-489-3p in Apoe;5/6Nx with a single injection of HDL + LNA inhibitors significantly reduced atherosclerotic lesion area by 28.6% compared to HDL + LNA scramble (LNA-Scr) controls. To examine the impact of dual LNA treatment on aortic endothelial gene expression, total RNA sequencing was completed, and multiple putative target genes and pathways were identified to be significantly altered, including the STAT3 immune response pathway. Among the differentially expressed genes, Tgfb2 and Fam220a were identified as putative targets of miR-489-3p and miR-92a-3p, respectively. Both Tgfb2 and Fam220a were significantly increased in aortic endothelium after miRNA inhibition in vivo compared to HDL + LNA-Scr controls. Furthermore, Tgfb2 and Fam220a were validated with gene reporter assays as direct targets of miR-489-3p and miR-92a-3p, respectively. In human coronary artery endothelial cells, over-expression and inhibition of miR-92a-3p decreased and increased FAM220A expression, respectively. Moreover, miR-92a-3p overexpression increased STAT3 phosphorylation, likely through direct regulation of FAM220A, a negative regulator of STAT3 phosphorylation.
CONCLUSIONS - These results support endothelial miRNAs as therapeutic targets and dual miRNA inhibition as viable strategy to reduce CKD-associated atherosclerosis.
Copyright © 2019. Published by Elsevier B.V.
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24 MeSH Terms
Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation.
Brophy ML, Dong Y, Tao H, Yancey PG, Song K, Zhang K, Wen A, Wu H, Lee Y, Malovichko MV, Sithu SD, Wong S, Yu L, Kocher O, Bischoff J, Srivastava S, Linton MF, Ley K, Chen H
(2019) Circ Res 124: e6-e19
MeSH Terms: Adaptor Proteins, Vesicular Transport, Animals, Apolipoproteins E, Atherosclerosis, Cells, Cultured, Down-Regulation, Gene Deletion, HEK293 Cells, Humans, Low Density Lipoprotein Receptor-Related Protein-1, Macrophages, Mice, Myeloid Cells, RAW 264.7 Cells, Receptors, LDL, Tumor Suppressor Proteins, Ubiquitination
Show Abstract · Added April 10, 2019
RATIONALE - Atherosclerosis is, in part, caused by immune and inflammatory cell infiltration into the vascular wall, leading to enhanced inflammation and lipid accumulation in the aortic endothelium. Understanding the molecular mechanisms underlying this disease is critical for the development of new therapies. Our recent studies demonstrate that epsins, a family of ubiquitin-binding endocytic adaptors, are critical regulators of atherogenicity. Given the fundamental contribution lesion macrophages make to fuel atherosclerosis, whether and how myeloid-specific epsins promote atherogenesis is an open and significant question.
OBJECTIVE - We will determine the role of myeloid-specific epsins in regulating lesion macrophage function during atherosclerosis.
METHODS AND RESULTS - We engineered myeloid cell-specific epsins double knockout mice (LysM-DKO) on an ApoE background. On Western diet, these mice exhibited marked decrease in atherosclerotic lesion formation, diminished immune and inflammatory cell content in aortas, and reduced necrotic core content but increased smooth muscle cell content in aortic root sections. Epsins deficiency hindered foam cell formation and suppressed proinflammatory macrophage phenotype but increased efferocytosis and anti-inflammatory macrophage phenotype in primary macrophages. Mechanistically, we show that epsin loss specifically increased total and surface levels of LRP-1 (LDLR [low-density lipoprotein receptor]-related protein 1), an efferocytosis receptor with antiatherosclerotic properties. We further show that epsin and LRP-1 interact via epsin's ubiquitin-interacting motif domain. ox-LDL (oxidized LDL) treatment increased LRP-1 ubiquitination, subsequent binding to epsin, and its internalization from the cell surface, suggesting that epsins promote the ubiquitin-dependent internalization and downregulation of LRP-1. Crossing ApoE/LysM-DKO mice onto an LRP-1 heterozygous background restored, in part, atherosclerosis, suggesting that epsin-mediated LRP-1 downregulation in macrophages plays a pivotal role in propelling atherogenesis.
CONCLUSIONS - Myeloid epsins promote atherogenesis by facilitating proinflammatory macrophage recruitment and inhibiting efferocytosis in part by downregulating LRP-1, implicating that targeting epsins in macrophages may serve as a novel therapeutic strategy to treat atherosclerosis.
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17 MeSH Terms
Loss of 2 Akt (Protein Kinase B) Isoforms in Hematopoietic Cells Diminished Monocyte and Macrophage Survival and Reduces Atherosclerosis in Ldl Receptor-Null Mice.
Babaev VR, Ding L, Zhang Y, May JM, Ramsey SA, Vickers KC, Linton MF
(2019) Arterioscler Thromb Vasc Biol 39: 156-169
MeSH Terms: Animals, Atherosclerosis, Cell Survival, Female, Hematopoietic System, Macrophages, Male, Mice, Mice, Inbred C57BL, Monocytes, Protein Isoforms, Proto-Oncogene Proteins c-akt, Receptors, LDL
Show Abstract · Added April 10, 2019
Objective- Macrophages express 3 Akt (protein kinase B) isoforms, Akt1, Akt2, and Akt3, which display isoform-specific functions but may be redundant in terms of Akt survival signaling. We hypothesize that loss of 2 Akt isoforms in macrophages will suppress their ability to survive and modulate the development of atherosclerosis. Approach and Results- To test this hypothesis, we reconstituted male Ldlr mice with double Akt2/Akt3 knockout hematopoietic cells expressing only the Akt1 isoform (Akt1). There were no differences in body weight and plasma lipid levels between the groups after 8 weeks of the Western diet; however, Akt1→ Ldlr mice developed smaller (57.6% reduction) atherosclerotic lesions with more apoptotic macrophages than control mice transplanted with WT (wild type) cells. Next, male and female Ldlr mice were reconstituted with double Akt1/Akt2 knockout hematopoietic cells expressing the Akt3 isoform (Akt3). Female and male Akt3→ Ldlr recipients had significantly smaller (61% and 41%, respectively) lesions than the control WT→ Ldlr mice. Loss of 2 Akt isoforms in hematopoietic cells resulted in markedly diminished levels of white blood cells, B cells, and monocytes and compromised viability of monocytes and peritoneal macrophages compared with WT cells. In response to lipopolysaccharides, macrophages with a single Akt isoform expressed low levels of inflammatory cytokines; however, Akt1 macrophages were distinct in expressing high levels of antiapoptotic Il10 compared with WT and Akt3 cells. Conclusions- Loss of 2 Akt isoforms in hematopoietic cells, preserving only a single Akt1 or Akt3 isoform, markedly compromises monocyte and macrophage viability and diminishes early atherosclerosis in Ldlr mice.
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13 MeSH Terms