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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 10

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Vitamin C deficiency in the brain impairs cognition, increases amyloid accumulation and deposition, and oxidative stress in APP/PSEN1 and normally aging mice.
Dixit S, Bernardo A, Walker JM, Kennard JA, Kim GY, Kessler ES, Harrison FE
(2015) ACS Chem Neurosci 6: 570-81
MeSH Terms: Aging, Alzheimer Disease, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Animals, Anxiety, Ascorbic Acid, Ascorbic Acid Deficiency, Brain, Cognition Disorders, Disease Models, Animal, Female, Learning, Male, Memory, Mice, Transgenic, Motor Activity, Oxidative Stress, Peptide Fragments, Presenilin-1, Sodium-Coupled Vitamin C Transporters
Added May 11, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms
Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease.
Warner TA, Kang JQ, Kennard JA, Harrison FE
(2015) Epilepsy Res 110: 20-5
MeSH Terms: Alzheimer Disease, Amyloid beta-Protein Precursor, Animals, Ascorbic Acid, Ascorbic Acid Deficiency, Brain, Disease Models, Animal, Electrodes, Implanted, Electroencephalography, Female, Humans, Kainic Acid, Male, Malondialdehyde, Mice, Knockout, Mice, Transgenic, Oxidative Stress, Pentylenetetrazole, Presenilin-1, Seizures, Sodium-Coupled Vitamin C Transporters
Added May 11, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms
Behavioral and monoamine changes following severe vitamin C deficiency.
Ward MS, Lamb J, May JM, Harrison FE
(2013) J Neurochem 124: 363-75
MeSH Terms: Animals, Ascorbic Acid, Ascorbic Acid Deficiency, Behavior, Animal, Biogenic Monoamines, Disease Models, Animal, Female, L-Gulonolactone Oxidase, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Severity of Illness Index
Added December 10, 2013
0 Communities
2 Members
0 Resources
13 MeSH Terms
Selective macrophage ascorbate deficiency suppresses early atherosclerosis.
Babaev VR, Whitesell RR, Li L, Linton MF, Fazio S, May JM
(2011) Free Radic Biol Med 50: 27-36
MeSH Terms: Animals, Apolipoproteins E, Ascorbic Acid, Ascorbic Acid Deficiency, Atherosclerosis, Cells, Cultured, Disease Progression, Female, Genetic Predisposition to Disease, Macrophages, Peritoneal, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Organ Specificity, Organic Anion Transporters, Sodium-Dependent, Sodium-Coupled Vitamin C Transporters, Symporters, Time Factors
Added December 5, 2013
2 Communities
0 Members
0 Resources
19 MeSH Terms
Vitamin C distribution and retention in the mouse brain.
Harrison FE, Green RJ, Dawes SM, May JM
(2010) Brain Res 1348: 181-6
MeSH Terms: Animals, Ascorbic Acid, Ascorbic Acid Deficiency, Brain, Disease Models, Animal, L-Gulonolactone Oxidase, Malondialdehyde, Mice, Mice, Inbred C57BL, Mice, Knockout, Oxidative Stress, Statistics, Nonparametric, Tissue Distribution
Added December 10, 2013
0 Communities
1 Members
0 Resources
13 MeSH Terms
Combined vitamin C and vitamin E deficiency worsens early atherosclerosis in apolipoprotein E-deficient mice.
Babaev VR, Li L, Shah S, Fazio S, Linton MF, May JM
(2010) Arterioscler Thromb Vasc Biol 30: 1751-7
MeSH Terms: Animals, Aortic Diseases, Apolipoproteins E, Ascorbic Acid, Ascorbic Acid Deficiency, Atherosclerosis, Brain, Dietary Supplements, Disease Models, Animal, Disease Progression, Female, L-Gulonolactone Oxidase, Lipid Peroxidation, Liver, Macrophages, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Myocardium, Organic Anion Transporters, Sodium-Dependent, Oxidative Stress, Severity of Illness Index, Sex Factors, Sodium-Coupled Vitamin C Transporters, Symporters, Time Factors, Vitamin E, Vitamin E Deficiency, Vitamins
Added December 10, 2013
0 Communities
2 Members
0 Resources
30 MeSH Terms
Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic mice.
Harrison FE, May JM, McDonald MP
(2010) Pharmacol Biochem Behav 94: 543-52
MeSH Terms: Amyloid, Amyloid beta-Protein Precursor, Animals, Ascorbic Acid, Ascorbic Acid Deficiency, Brain, Exploratory Behavior, Female, L-Gulonolactone Oxidase, Lipid Peroxidation, Male, Maze Learning, Mice, Mice, Transgenic, Oxidative Stress, Presenilin-1, Survival Rate
Added December 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid.
Harrison FE, Yu SS, Van Den Bossche KL, Li L, May JM, McDonald MP
(2008) J Neurochem 106: 1198-208
MeSH Terms: Animals, Ascorbic Acid, Ascorbic Acid Deficiency, Cognition, Female, L-Gulonolactone Oxidase, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Motor Activity, Motor Skills Disorders, Oxidative Stress, Psychomotor Performance
Added December 10, 2013
0 Communities
1 Members
0 Resources
14 MeSH Terms
A combined deficiency of vitamins E and C causes severe central nervous system damage in guinea pigs.
Burk RF, Christensen JM, Maguire MJ, Austin LM, Whetsell WO, May JM, Hill KE, Ebner FF
(2006) J Nutr 136: 1576-81
MeSH Terms: Animals, Antioxidants, Ascorbic Acid Deficiency, Central Nervous System Diseases, Diet, Guinea Pigs, Male, Vitamin E Deficiency
Added December 10, 2013
0 Communities
2 Members
0 Resources
8 MeSH Terms
Combined deficiency of vitamins E and C causes paralysis and death in guinea pigs.
Hill KE, Montine TJ, Motley AK, Li X, May JM, Burk RF
(2003) Am J Clin Nutr 77: 1484-8
MeSH Terms: Animals, Ascorbic Acid, Ascorbic Acid Deficiency, Brain, Disease Models, Animal, Guinea Pigs, Male, Osmolar Concentration, Paralysis, Sciatic Nerve, Spinal Cord, Vitamin E Deficiency, alpha-Tocopherol
Added December 10, 2013
0 Communities
2 Members
0 Resources
13 MeSH Terms