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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 9 of 9

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Combined effect of CYP2B6 and NAT2 genotype on plasma efavirenz exposure during rifampin-based antituberculosis therapy in the STRIDE study.
Luetkemeyer AF, Rosenkranz SL, Lu D, Grinsztejn B, Sanchez J, Ssemmanda M, Sanne I, McIlleron H, Havlir DV, Haas DW, Adult AIDS Clinical Trials Group A5221 and A5243 Study Teams
(2015) Clin Infect Dis 60: 1860-3
MeSH Terms: Alkynes, Antitubercular Agents, Arylamine N-Acetyltransferase, Benzoxazines, Cyclopropanes, Cytochrome P-450 CYP2B6, Female, Genotype, HIV Infections, Humans, Male, Peru, Pharmacogenetics, Rifampin, South Africa, Tuberculosis, Uganda
Added March 13, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Activation of aminophenylnorharman, aminomethylphenylnorharman and aminophenylharman to genotoxic metabolites by human N-acetyltransferases and cytochrome P450 enzymes expressed in Salmonella typhimurium umu tester strains.
Oda Y, Totsuka Y, Wakabayashi K, Guengerich FP, Shimada T
(2006) Mutagenesis 21: 411-6
MeSH Terms: Aniline Compounds, Arylamine N-Acetyltransferase, Cytochrome P-450 CYP1A2, DNA Damage, Humans, Indoles, Isoenzymes, Microsomes, Liver, Mutagenicity Tests, Mutagens, Phthalazines, Pyridines, Salmonella typhimurium, Toluidines, beta-Galactosidase
Added March 26, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Cytochrome P450 activation of arylamines and heterocyclic amines.
Kim D, Guengerich FP
(2005) Annu Rev Pharmacol Toxicol 45: 27-49
MeSH Terms: Amines, Animals, Arylamine N-Acetyltransferase, Cytochrome P-450 Enzyme System, Enzyme Activation, Heterocyclic Compounds, Humans
Added March 5, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms
Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferase.
Oda Y, Aryal P, Terashita T, Gillam EM, Guengerich FP, Shimada T
(2001) Mutat Res 492: 81-90
MeSH Terms: Acetyltransferases, Amines, Arylamine N-Acetyltransferase, Carcinogens, Cytochrome P-450 Enzyme System, Dose-Response Relationship, Drug, Enzyme Activation, Fluorenes, Heterocyclic Compounds, Humans, Isoenzymes, Mutagenicity Tests, Mutagens, NADPH-Ferrihemoprotein Reductase, Salmonella typhimurium, Sensitivity and Specificity
Added May 26, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Tissue- and gender-specific expression of N-acetyltransferase 2 (Nat2*) during development of the outbred mouse strain CD-1.
Estrada L, Kanelakis KC, Levy GN, Weber WW
(2000) Drug Metab Dispos 28: 139-46
MeSH Terms: Aging, Alleles, Animals, Arylamine N-Acetyltransferase, Cytosol, Female, Genotype, Immunoblotting, Kidney, Liver, Male, Mice, Organ Specificity, Phenotype, Plasmids, Polymerase Chain Reaction, Polymorphism, Genetic, RNA, Messenger, Ribonucleases, Sex Characteristics
Added February 27, 2013
0 Communities
1 Members
0 Resources
20 MeSH Terms
Characterization of a hormone response element in the mouse N-acetyltransferase 2 (Nat2*) promoter.
Estrada-Rodgers L, Levy GN, Weber WW
(1998) Gene Expr 7: 13-24
MeSH Terms: Animals, Arylamine N-Acetyltransferase, Base Sequence, Binding Sites, Cells, Cultured, Codon, Initiator, DNA, Genes, Reporter, Hormones, Humans, Kidney, Male, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Promoter Regions, Genetic, Sex Characteristics, Sp1 Transcription Factor, TATA Box, Transcription Factor AP-1, Transcription, Genetic
Added February 27, 2013
0 Communities
1 Members
0 Resources
21 MeSH Terms
Metabolic activation of aromatic amine mutagens by simultaneous expression of human cytochrome P450 1A2, NADPH-cytochrome P450 reductase, and N-acetyltransferase in Escherichia coli.
Josephy PD, Evans DH, Parikh A, Guengerich FP
(1998) Chem Res Toxicol 11: 70-4
MeSH Terms: Arylamine N-Acetyltransferase, Biotransformation, Cytochrome P-450 CYP1A2, Escherichia coli, Humans, Hydrocarbons, Aromatic, Mutagens, NADH, NADPH Oxidoreductases, NADPH-Ferrihemoprotein Reductase, Plasmids
Added May 26, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Pineal and retinal serotonin N-acetyltransferase activity: modulation by phosphate.
Hamm HE, Menaker M
(1981) J Neurochem 37: 1567-72
MeSH Terms: Acetyltransferases, Animals, Arylamine N-Acetyltransferase, Brain, Cerebellum, Chickens, Darkness, Kinetics, Light, Liver, Organ Specificity, Osmolar Concentration, Phosphates, Pineal Gland, Retina
Added December 10, 2013
0 Communities
1 Members
0 Resources
15 MeSH Terms
Light-induced decrease of serotonin N-acetyltransferase activity and melatonin in the chicken pineal gland and retina.
Hamm HE, Takahashi JS, Menaker M
(1983) Brain Res 266: 287-93
MeSH Terms: Acetyltransferases, Animals, Arylamine N-Acetyltransferase, Brain, Chickens, Kinetics, Light, Melatonin, Organ Culture Techniques, Pineal Gland, Retina, Tissue Distribution
Added December 10, 2013
0 Communities
1 Members
0 Resources
12 MeSH Terms