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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 137

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Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1.
Albertolle ME, Song HD, Wilkey CJ, Segrest JP, Guengerich FP
(2019) Chem Res Toxicol 32: 484-492
MeSH Terms: Animals, Aryl Hydrocarbon Hydroxylases, Glutamine, Heme, Molecular Dynamics Simulation, Mutagenesis, Site-Directed, Oxidation-Reduction, Rabbits, Sulfenic Acids, Sulfhydryl Compounds
Added March 26, 2019
0 Communities
1 Members
0 Resources
10 MeSH Terms
Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants.
Shimada T, Murayama N, Kakimoto K, Takenaka S, Lim YR, Yeom S, Kim D, Yamazaki H, Guengerich FP, Komori M
(2018) Xenobiotica 48: 565-575
MeSH Terms: Alleles, Aryl Hydrocarbon Hydroxylases, Biocatalysis, Cytochrome P-450 CYP1B1, Humans, Molecular Docking Simulation, Oxidation-Reduction, Pyrenes
Added March 14, 2018
0 Communities
1 Members
0 Resources
8 MeSH Terms
Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6.
Shimada T, Takenaka S, Kakimoto K, Murayama N, Lim YR, Kim D, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M
(2016) Chem Res Toxicol 29: 1029-40
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Biphenyl Compounds, Cytochrome P-450 CYP2A6, Humans, Molecular Structure, Naphthalenes, Oxidation-Reduction, Phenanthrenes
Added March 14, 2018
0 Communities
1 Members
0 Resources
8 MeSH Terms
Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13.
Shimada T, Takenaka S, Murayama N, Kramlinger VM, Kim JH, Kim D, Liu J, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M
(2016) Xenobiotica 46: 211-24
MeSH Terms: Animals, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP2A6, Humans, Lepidoptera, Models, Biological, Molecular Docking Simulation, Oxidation-Reduction, Polycyclic Compounds, Pyrenes
Added March 14, 2018
0 Communities
1 Members
0 Resources
11 MeSH Terms
Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction.
Bajpai P, Srinivasan S, Ghosh J, Nagy LD, Wei S, Guengerich FP, Avadhani NG
(2014) J Biol Chem 289: 29614-30
MeSH Terms: Alternative Splicing, Amino Acid Sequence, Amino Acids, Animals, Arachidonic Acid, Aryl Hydrocarbon Hydroxylases, Biocatalysis, COS Cells, Cell Respiration, Chlorocebus aethiops, Computer Simulation, Cytochrome P-450 CYP2C8, Heme, Hep G2 Cells, Humans, Isoenzymes, Microsomes, Liver, Mitochondria, Models, Molecular, Molecular Sequence Data, Oxidation-Reduction, Oxidative Stress, Protein Binding, Protein Transport, RNA, Messenger, Reactive Oxygen Species, Sequence Alignment
Added January 20, 2015
0 Communities
2 Members
0 Resources
27 MeSH Terms
The role of cytochrome P450 epoxygenases in retinal angiogenesis.
Capozzi ME, McCollum GW, Penn JS
(2014) Invest Ophthalmol Vis Sci 55: 4253-60
MeSH Terms: Animals, Animals, Newborn, Aryl Hydrocarbon Hydroxylases, Astrocytes, Cell Proliferation, Cells, Cultured, Cytochrome P-450 CYP2C8, Cytochrome P-450 CYP2C9, Cytochrome P-450 CYP2J2, Cytochrome P-450 Enzyme System, Disease Models, Animal, Endothelium, Vascular, Enzyme-Linked Immunosorbent Assay, Female, Gene Expression Regulation, Developmental, Humans, Microcirculation, RNA, Messenger, Rats, Rats, Sprague-Dawley, Real-Time Polymerase Chain Reaction, Retina, Retinal Neovascularization, Vascular Endothelial Growth Factor A
Added February 19, 2015
1 Communities
1 Members
0 Resources
24 MeSH Terms
The impact of age and CYP2C9 and VKORC1 variants on stable warfarin dose in the paediatric population.
Vear SI, Ayers GD, Van Driest SL, Sidonio RF, Stein CM, Ho RH
(2014) Br J Haematol 165: 832-5
MeSH Terms: Adolescent, Age Factors, Alleles, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Child, Child, Preschool, Cross-Sectional Studies, Cytochrome P-450 CYP2C9, Genetic Variation, Genotype, Humans, Infant, Pharmacogenetics, Retrospective Studies, Vitamin K Epoxide Reductases, Warfarin
Added March 10, 2014
1 Communities
3 Members
0 Resources
17 MeSH Terms
Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction.
Bansal S, Leu AN, Gonzalez FJ, Guengerich FP, Chowdhury AR, Anandatheerthavarada HK, Avadhani NG
(2014) J Biol Chem 289: 9936-51
MeSH Terms: Adrenodoxin, Animals, Aryl Hydrocarbon Hydroxylases, Benzo(a)pyrene, COS Cells, Cell Line, Tumor, Chlorocebus aethiops, Cytochrome P-450 CYP1B1, Female, Humans, Male, Mice, Mice, Knockout, Mitochondria, Mutagenesis, Oxidation-Reduction, Oxygen Consumption, Polychlorinated Dibenzodioxins, Protein Sorting Signals, Protein Transport, Teratogens
Added March 10, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor.
Murayama N, van Beuningen R, Suemizu H, Guillouzo CG, Shibata N, Yajima K, Utoh M, Shimizu M, Chesné C, Nakamura M, Guengerich FP, Houtman R, Yamazaki H
(2014) Chem Res Toxicol 27: 304-308
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Biotransformation, Cell Line, Cells, Cultured, Cytochrome P-450 CYP2B6, Cytochrome P-450 CYP3A, Hepatocytes, Humans, Pregnane X Receptor, Protein Array Analysis, Receptors, Cytoplasmic and Nuclear, Receptors, Steroid, Thalidomide
Added March 10, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Influence of dietary fat type on benzo(a)pyrene [B(a)P] biotransformation in a B(a)P-induced mouse model of colon cancer.
Diggs DL, Myers JN, Banks LD, Niaz MS, Hood DB, Roberts LJ, Ramesh A
(2013) J Nutr Biochem 24: 2051-63
MeSH Terms: Animals, Aryl Hydrocarbon Hydroxylases, Benzo(a)pyrene, Biotransformation, Carcinogens, Chromatography, Thin Layer, Colon, Colonic Neoplasms, Cytochrome P-450 CYP1B1, DNA Adducts, Dietary Fats, Disease Models, Animal, Liver, Male, Mice
Added March 7, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms