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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 34

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Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice.
Brandt SL, Klopfenstein N, Wang S, Winfree S, McCarthy BP, Territo PR, Miller L, Serezani CH
(2018) PLoS Pathog 14: e1007244
MeSH Terms: Abscess, Animals, Arachidonate 5-Lipoxygenase, Bacterial Load, Cells, Cultured, Female, Leukotriene B4, Macrophages, Male, Methicillin-Resistant Staphylococcus aureus, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, Leukotriene B4, Staphylococcal Skin Infections
Added March 18, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Identification of Proteomic Features To Distinguish Benign Pulmonary Nodules from Lung Adenocarcinoma.
Codreanu SG, Hoeksema MD, Slebos RJC, Zimmerman LJ, Rahman SMJ, Li M, Chen SC, Chen H, Eisenberg R, Liebler DC, Massion PP
(2017) J Proteome Res 16: 3266-3276
MeSH Terms: 5-Lipoxygenase-Activating Proteins, Adenocarcinoma, Adenocarcinoma of Lung, Adult, Aged, Antigens, CD, Arachidonate 5-Lipoxygenase, Biomarkers, Tumor, CD11 Antigens, Cell Adhesion Molecules, Diagnosis, Differential, Female, GPI-Linked Proteins, Gene Expression Regulation, Neoplastic, Glucose Transporter Type 3, Humans, Integrin alpha Chains, Lung Neoplasms, Male, Middle Aged, Neoplasm Proteins, Proteomics, Respiratory Mucosa, Solitary Pulmonary Nodule, Tandem Mass Spectrometry, Tissue Array Analysis, Transcriptome
Added January 29, 2018
0 Communities
1 Members
0 Resources
27 MeSH Terms
Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality.
Zoccal KF, Sorgi CA, Hori JI, Paula-Silva FW, Arantes EC, Serezani CH, Zamboni DS, Faccioli LH
(2016) Nat Commun 7: 10760
MeSH Terms: Animals, Arachidonate 5-Lipoxygenase, Blotting, Western, Carrier Proteins, Celecoxib, Cyclic AMP, Cyclic AMP-Dependent Protein Kinases, Cyclooxygenase Inhibitors, Dinoprostone, In Vitro Techniques, Indoles, Indomethacin, Inflammasomes, Interleukin-1beta, Leukotriene B4, Lipoxygenase Inhibitors, Macrophages, Macrophages, Peritoneal, Mice, Mice, Knockout, NF-kappa B, NLR Family, Pyrin Domain-Containing 3 Protein, Phosphoproteins, Prostaglandin Antagonists, Receptors, Prostaglandin E, EP2 Subtype, Receptors, Prostaglandin E, EP4 Subtype, Reverse Transcriptase Polymerase Chain Reaction, Scorpion Stings, Scorpion Venoms, Scorpions, Xanthones
Added May 4, 2017
0 Communities
1 Members
0 Resources
31 MeSH Terms
Lipoxin Inhibits Fungal Uptake by Macrophages and Reduces the Severity of Acute Pulmonary Infection Caused by Paracoccidioides brasiliensis.
Ribeiro LR, Loures FV, de Araújo EF, Feriotti C, Costa TA, Serezani CH, Jancar S, Calich VL
(2015) Mediators Inflamm 2015: 852574
MeSH Terms: Acetates, Animals, Arachidonate 5-Lipoxygenase, Dinoprostone, Inflammation Mediators, Leukotriene Antagonists, Leukotriene C4, Lipoxins, Macrophages, Alveolar, Male, Mice, Mice, 129 Strain, Mice, Inbred A, Mice, Knockout, Paracoccidioides, Paracoccidioidomycosis, Quinolines, Receptors, Leukotriene, Receptors, Pattern Recognition
Added May 4, 2017
0 Communities
1 Members
0 Resources
19 MeSH Terms
Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes.
Filgueiras LR, Brandt SL, Wang S, Wang Z, Morris DL, Evans-Molina C, Mirmira RG, Jancar S, Serezani CH
(2015) Sci Signal 8: ra10
MeSH Terms: Analysis of Variance, Animals, Arachidonate 5-Lipoxygenase, Chromatin Immunoprecipitation, Cytokines, Diabetes Mellitus, Type 1, Female, Gene Expression Regulation, Immunoblotting, Inflammation, Inflammation Mediators, Insulin, Leukotriene B4, Macrophages, Mice, Mice, Knockout, Myeloid Differentiation Factor 88, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, STAT1 Transcription Factor, Sepsis
Added May 4, 2017
0 Communities
1 Members
0 Resources
21 MeSH Terms
Inhibitors of the 5-lipoxygenase arachidonic acid pathway induce ATP release and ATP-dependent organic cation transport in macrophages.
da Silva-Souza HA, Lira MN, Costa-Junior HM, da Cruz CM, Vasconcellos JS, Mendes AN, Pimenta-Reis G, Alvarez CL, Faccioli LH, Serezani CH, Schachter J, Persechini PM
(2014) Biochim Biophys Acta 1838: 1967-77
MeSH Terms: Adenosine Triphosphate, Animals, Arachidonate 5-Lipoxygenase, Calcium, Cations, Ion Transport, Lipoxygenase Inhibitors, Macrophages, Mice, Mice, Inbred C57BL, Phospholipases A2, Receptors, Purinergic P2X7
Added May 4, 2017
0 Communities
1 Members
0 Resources
12 MeSH Terms
The leukotriene B₄/BLT₁ axis is a key determinant in susceptibility and resistance to histoplasmosis.
Secatto A, Soares EM, Locachevic GA, Assis PA, Paula-Silva FW, Serezani CH, de Medeiros AI, Faccioli LH
(2014) PLoS One 9: e85083
MeSH Terms: Animals, Arachidonate 5-Lipoxygenase, Disease Susceptibility, Enzyme Inhibitors, Gene Expression, Histoplasma, Histoplasmosis, Host Specificity, Host-Pathogen Interactions, Leukotriene B4, Lung, Macrophages, Mice, Mice, 129 Strain, Mice, Inbred C57BL, Phagocytosis, Receptors, Leukotriene B4, Rodent Diseases, Signal Transduction, Spleen
Added May 4, 2017
0 Communities
1 Members
0 Resources
20 MeSH Terms
Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers.
Mohebati A, Milne GL, Zhou XK, Duffield-Lillico AJ, Boyle JO, Knutson A, Bosworth BP, Kingsley PJ, Marnett LJ, Brown PH, Akpa EG, Szabo E, Dannenberg AJ
(2013) Cancer Prev Res (Phila) 6: 646-55
MeSH Terms: Adult, Arachidonate 5-Lipoxygenase, Biomarkers, Celecoxib, Chromatography, Liquid, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Female, Humans, Hydroxyurea, Leukotriene E4, Lipoxygenase Inhibitors, Male, Maximum Tolerated Dose, Prognosis, Prostaglandins, Pyrazoles, Smoking, Sulfonamides, Tandem Mass Spectrometry
Added March 7, 2014
1 Communities
2 Members
0 Resources
20 MeSH Terms
Leukotriene B4 enhances innate immune defense against the puerperal sepsis agent Streptococcus pyogenes.
Soares EM, Mason KL, Rogers LM, Serezani CH, Faccioli LH, Aronoff DM
(2013) J Immunol 190: 1614-22
MeSH Terms: Adolescent, Adult, Animals, Arachidonate 5-Lipoxygenase, Cells, Cultured, Female, Genetic Predisposition to Disease, Humans, Immunity, Innate, Leukotriene B4, Mice, Mice, Inbred C57BL, Mice, Knockout, Puerperal Infection, Sepsis, Streptococcal Infections, Up-Regulation, Young Adult
Added May 4, 2017
0 Communities
1 Members
0 Resources
18 MeSH Terms
Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663.
Gilbert NC, Rui Z, Neau DB, Waight MT, Bartlett SG, Boeglin WE, Brash AR, Newcomer ME
(2012) FASEB J 26: 3222-9
MeSH Terms: Arachidonate 15-Lipoxygenase, Arachidonate 5-Lipoxygenase, Arachidonic Acid, Humans, Lipoxins, Models, Molecular, Phosphorylation, Point Mutation, Serine
Added January 21, 2015
0 Communities
1 Members
0 Resources
9 MeSH Terms