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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 35

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Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction.
Teder T, Boeglin WE, Brash AR
(2014) J Lipid Res 55: 2587-96
MeSH Terms: 8,11,14-Eicosatrienoic Acid, Animals, Arachidonate 12-Lipoxygenase, Arachidonate 15-Lipoxygenase, Biocatalysis, Blood Platelets, Chromatography, High Pressure Liquid, Eicosanoids, Epoxy Compounds, Gas Chromatography-Mass Spectrometry, Humans, Hydroxylation, Linolenic Acids, Lipid Peroxides, Lipoxygenase, Mice, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Oxidation-Reduction, Recombinant Proteins, Soybean Proteins, Spectrometry, Mass, Electrospray Ionization, Stereoisomerism
Added January 21, 2015
0 Communities
1 Members
0 Resources
23 MeSH Terms
The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier.
Muñoz-Garcia A, Thomas CP, Keeney DS, Zheng Y, Brash AR
(2014) Biochim Biophys Acta 1841: 401-8
MeSH Terms: 8,11,14-Eicosatrienoic Acid, Animals, Arachidonate 12-Lipoxygenase, Ceramides, Epidermis, Humans, Lipid Metabolism, Lipoxygenase
Added March 7, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity.
Yeung J, Apopa PL, Vesci J, Stolla M, Rai G, Simeonov A, Jadhav A, Fernandez-Perez P, Maloney DJ, Boutaud O, Holman TR, Holinstat M
(2013) Thromb Haemost 110: 569-81
MeSH Terms: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid, Animals, Arachidonate 12-Lipoxygenase, Blood Platelets, Cyclooxygenase 1, Eicosanoids, Flow Cytometry, Humans, Mice, Mice, Transgenic, Platelet Activation, Platelet Adhesiveness, Platelet Aggregation, Platelet Membrane Glycoproteins, Receptors, Thrombin, Thrombosis, Time Factors
Added March 27, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis.
Xu S, Mueser TC, Marnett LJ, Funk MO
(2012) Structure 20: 1490-7
MeSH Terms: Animals, Arachidonate 12-Lipoxygenase, Biocatalysis, Catalytic Domain, Coordination Complexes, Crystallography, X-Ray, Hydrogen Bonding, Hydrophobic and Hydrophilic Interactions, Iron, Lipoxygenase Inhibitors, Models, Molecular, Oxygen, Phenylpropionates, Protein Binding, Protein Structure, Secondary, Sus scrofa
Added June 1, 2014
0 Communities
2 Members
0 Resources
16 MeSH Terms
Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation.
Yeung J, Apopa PL, Vesci J, Kenyon V, Rai G, Jadhav A, Simeonov A, Holman TR, Maloney DJ, Boutaud O, Holinstat M
(2012) Mol Pharmacol 81: 420-30
MeSH Terms: Arachidonate 12-Lipoxygenase, Blood Platelets, Blotting, Western, Calcium, Enzyme Activation, Flow Cytometry, Gas Chromatography-Mass Spectrometry, Humans, Lipoxygenase Inhibitors, Platelet Activation, Platelet Glycoprotein GPIIb-IIIa Complex, Protein Kinase C, Protein Kinase Inhibitors
Added March 27, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope.
Zheng Y, Yin H, Boeglin WE, Elias PM, Crumrine D, Beier DR, Brash AR
(2011) J Biol Chem 286: 24046-56
MeSH Terms: Animals, Arachidonate 12-Lipoxygenase, Ceramides, Epidermis, Fatty Acids, Essential, Lipoxygenase, Mice, Oxidation-Reduction, Swine
Added December 10, 2013
0 Communities
1 Members
0 Resources
9 MeSH Terms
Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis.
Holinstat M, Boutaud O, Apopa PL, Vesci J, Bala M, Oates JA, Hamm HE
(2011) Arterioscler Thromb Vasc Biol 31: 435-42
MeSH Terms: 1-Butanol, 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid, Arachidonate 12-Lipoxygenase, Arachidonic Acid, Blood Platelets, Calcium, Chromones, Cyclooxygenase 1, Cytosol, Eicosanoids, Enzyme Inhibitors, Group IV Phospholipases A2, Humans, In Vitro Techniques, Morpholines, Propranolol, Protein Kinase C, Receptors, Proteinase-Activated, Signal Transduction, Thromboxane A2, p38 Mitogen-Activated Protein Kinases
Added March 20, 2014
1 Communities
2 Members
0 Resources
21 MeSH Terms
EPR spectroscopy and electrospray ionization mass spectrometry reveal distinctive features of the iron site in leukocyte 12-lipoxygenase.
Rapp J, Xu S, Sharp AM, Griffith WP, Kim YW, Funk MO
(2009) Arch Biochem Biophys 490: 50-6
MeSH Terms: Amino Acid Sequence, Animals, Arachidonate 12-Lipoxygenase, Electron Spin Resonance Spectroscopy, Escherichia coli, Hydrogen-Ion Concentration, Iron, Leukocytes, Lipid Peroxides, Molecular Weight, Oxidation-Reduction, Recombinant Proteins, Spectrometry, Mass, Electrospray Ionization, Sus scrofa, Temperature, Transformation, Genetic
Added April 14, 2017
0 Communities
1 Members
0 Resources
16 MeSH Terms
Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.
Turman MV, Kingsley PJ, Rouzer CA, Cravatt BF, Marnett LJ
(2008) Biochemistry 47: 3917-25
MeSH Terms: Amidohydrolases, Animals, Arachidonate 12-Lipoxygenase, Arachidonate 15-Lipoxygenase, Arachidonic Acids, Chromatography, Liquid, Cyclooxygenase 2, Female, Humans, Kinetics, Macrophages, Peritoneal, Mass Spectrometry, Mice, Oxidation-Reduction, Taurine
Added March 5, 2014
0 Communities
2 Members
0 Resources
15 MeSH Terms
A mouse mutation in the 12R-lipoxygenase, Alox12b, disrupts formation of the epidermal permeability barrier.
Moran JL, Qiu H, Turbe-Doan A, Yun Y, Boeglin WE, Brash AR, Beier DR
(2007) J Invest Dermatol 127: 1893-7
MeSH Terms: Animals, Arachidonate 12-Lipoxygenase, Codon, Nonsense, Epidermis, Genotype, Ichthyosiform Erythroderma, Congenital, Mice, Permeability
Added December 10, 2013
0 Communities
1 Members
0 Resources
8 MeSH Terms