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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 122

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Selective allosteric modulation of muscarinic acetylcholine receptors for the treatment of schizophrenia and substance use disorders.
Teal LB, Gould RW, Felts AS, Jones CK
(2019) Adv Pharmacol 86: 153-196
MeSH Terms: Allosteric Regulation, Animals, Antipsychotic Agents, Humans, Receptors, Muscarinic, Schizophrenia, Signal Transduction, Substance-Related Disorders
Added March 18, 2020
0 Communities
1 Members
0 Resources
8 MeSH Terms
Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness.
Girard TD, Exline MC, Carson SS, Hough CL, Rock P, Gong MN, Douglas IS, Malhotra A, Owens RL, Feinstein DJ, Khan B, Pisani MA, Hyzy RC, Schmidt GA, Schweickert WD, Hite RD, Bowton DL, Masica AL, Thompson JL, Chandrasekhar R, Pun BT, Strength C, Boehm LM, Jackson JC, Pandharipande PP, Brummel NE, Hughes CG, Patel MB, Stollings JL, Bernard GR, Dittus RS, Ely EW, MIND-USA Investigators
(2018) N Engl J Med 379: 2506-2516
MeSH Terms: Aged, Antipsychotic Agents, Critical Illness, Delirium, Dopamine Antagonists, Double-Blind Method, Female, Haloperidol, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Piperazines, Respiratory Insufficiency, Shock, Thiazoles, Treatment Failure
Added October 23, 2018
0 Communities
2 Members
0 Resources
17 MeSH Terms
Activation of the mGlu metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M muscarinic receptor allosteric modulators.
Yohn SE, Foster DJ, Covey DP, Moehle MS, Galbraith J, Garcia-Barrantes PM, Cho HP, Bubser M, Blobaum AL, Joffe ME, Cheer JF, Jones CK, Lindsley CW, Conn PJ
(2020) Mol Psychiatry 25: 2786-2799
MeSH Terms: Allosteric Regulation, Animals, Antipsychotic Agents, Glutamic Acid, Mice, Mice, Inbred C57BL, Receptor, Muscarinic M4, Receptors, Metabotropic Glutamate
Added March 18, 2020
0 Communities
1 Members
0 Resources
8 MeSH Terms
Mutual activation of glutamatergic mGlu and muscarinic M receptors reverses schizophrenia-related changes in rodents.
Cieślik P, Woźniak M, Rook JM, Tantawy MN, Conn PJ, Acher F, Tokarski K, Kusek M, Pilc A, Wierońska JM
(2018) Psychopharmacology (Berl) 235: 2897-2913
MeSH Terms: Amphetamine, Animals, Antipsychotic Agents, Disease Models, Animal, Dizocilpine Maleate, Dose-Response Relationship, Drug, Excitatory Amino Acid Agonists, Male, Mice, Motor Activity, Phosphinic Acids, Receptor, Muscarinic M4, Receptors, Metabotropic Glutamate, Rodentia, Schizophrenia
Added April 11, 2019
0 Communities
2 Members
0 Resources
MeSH Terms
A Novel M PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity.
Rook JM, Bertron JL, Cho HP, Garcia-Barrantes PM, Moran SP, Maksymetz JT, Nance KD, Dickerson JW, Remke DH, Chang S, Harp JM, Blobaum AL, Niswender CM, Jones CK, Stauffer SR, Conn PJ, Lindsley CW
(2018) ACS Chem Neurosci 9: 2274-2285
MeSH Terms: Allosteric Regulation, Animals, Antipsychotic Agents, CHO Cells, Cognition, Cognitive Dysfunction, Conditioning, Psychological, Cricetulus, Exploratory Behavior, Fear, Mice, Morpholines, Prefrontal Cortex, Pyrazoles, Rats, Risperidone, Seizures
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Intensive Care Unit Delirium and Intensive Care Unit-Related Posttraumatic Stress Disorder.
Marra A, Pandharipande PP, Patel MB
(2017) Surg Clin North Am 97: 1215-1235
MeSH Terms: Antipsychotic Agents, Brain Diseases, Cognition Disorders, Conscious Sedation, Critical Care, Critical Illness, Delirium, Early Ambulation, Exercise Therapy, Family, Humans, Pain Measurement, Stress Disorders, Post-Traumatic, Ventilator Weaning
Added June 26, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Liraglutide for the Treatment of Antipsychotic Drug-Induced Weight Gain.
Deutch AY
(2017) JAMA Psychiatry 74: 1172-1173
MeSH Terms: Antipsychotic Agents, Clozapine, Humans, Liraglutide, Obesity, Olanzapine, Overweight, Prediabetic State, Schizophrenia, Weight Gain
Added April 2, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M PAM VU0467154.
Gould RW, Grannan MD, Gunter BW, Ball J, Bubser M, Bridges TM, Wess J, Wood MW, Brandon NJ, Duggan ME, Niswender CM, Lindsley CW, Conn PJ, Jones CK
(2018) Neuropharmacology 128: 492-502
MeSH Terms: Allosteric Regulation, Animals, Antipsychotic Agents, Brain, Cognition Disorders, Discrimination, Psychological, Disease Models, Animal, Dizocilpine Maleate, Dose-Response Relationship, Drug, Hyperkinesis, Male, Memory Disorders, Mice, Mice, Inbred C57BL, Mice, Knockout, Pyridazines, Receptor, Muscarinic M4, Schizophrenia, Thiophenes
Added March 3, 2020
0 Communities
2 Members
0 Resources
MeSH Terms
Role of mGlu Receptors and Inhibitory Neurotransmission in M Dependent Muscarinic LTD in the Prefrontal Cortex: Implications in Schizophrenia.
Ghoshal A, Moran SP, Dickerson JW, Joffe ME, Grueter BA, Xiang Z, Lindsley CW, Rook JM, Conn PJ
(2017) ACS Chem Neurosci 8: 2254-2265
MeSH Terms: Animals, Antipsychotic Agents, Cholinergic Agents, Cognition, Mice, Inbred C57BL, Neuronal Plasticity, Phencyclidine, Prefrontal Cortex, Receptor, Metabotropic Glutamate 5, Receptors, N-Methyl-D-Aspartate, Schizophrenia, Synaptic Transmission
Added March 21, 2018
0 Communities
1 Members
0 Resources
12 MeSH Terms
Reducing Antipsychotic Medication Use in Nursing Homes: A Qualitative Study of Nursing Staff Perceptions.
Simmons SF, Bonnett KR, Hollingsworth E, Kim J, Powers J, Habermann R, Newhouse P, Schlundt DG
(2018) Gerontologist 58: e239-e250
MeSH Terms: Accidental Falls, Adult, Antipsychotic Agents, Attitude of Health Personnel, Dementia, Female, Humans, Male, Middle Aged, Needs Assessment, Nursing Homes, Nursing Staff, Prescription Drug Overuse, Qualitative Research, Quality of Life, Social Perception
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms