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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 24

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Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu positive allosteric modulators that mitigate CYP1A2 induction liability.
Engers DW, Bollinger SR, Engers JL, Panarese JD, Breiner MM, Gregro A, Blobaum AL, Bronson JJ, Wu YJ, Macor JE, Rodriguez AL, Zamorano R, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR
(2018) Bioorg Med Chem Lett 28: 2641-2646
MeSH Terms: Allosteric Regulation, Animals, Antiparkinson Agents, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inducers, Drug Discovery, Enzyme Induction, Humans, Pyrazoles, Pyridines, Rats, Receptors, Metabotropic Glutamate, Structure-Activity Relationship
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Ventral striatal network connectivity reflects reward learning and behavior in patients with Parkinson's disease.
Petersen K, Van Wouwe N, Stark A, Lin YC, Kang H, Trujillo-Diaz P, Kessler R, Zald D, Donahue MJ, Claassen DO
(2018) Hum Brain Mapp 39: 509-521
MeSH Terms: Analysis of Variance, Antiparkinson Agents, Brain Mapping, Cerebrovascular Circulation, Dopamine Agonists, Female, Humans, Linear Models, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Neuropsychological Tests, Oxygen, Parkinson Disease, Reward, Ventral Striatum
Added March 21, 2018
0 Communities
2 Members
0 Resources
17 MeSH Terms
Focused stimulation of dorsal subthalamic nucleus improves reactive inhibitory control of action impulses.
van Wouwe NC, Pallavaram S, Phibbs FT, Martinez-Ramirez D, Neimat JS, Dawant BM, D'Haese PF, Kanoff KE, van den Wildenberg WPM, Okun MS, Wylie SA
(2017) Neuropsychologia 99: 37-47
MeSH Terms: Antiparkinson Agents, Deep Brain Stimulation, Dopamine Agents, Female, Humans, Imaging, Three-Dimensional, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Middle Aged, Motor Activity, Neuropsychological Tests, Parkinson Disease, Reaction Time, Subthalamic Nucleus
Added April 10, 2018
0 Communities
1 Members
0 Resources
15 MeSH Terms
Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers.
Niswender CM, Jones CK, Lin X, Bubser M, Thompson Gray A, Blobaum AL, Engers DW, Rodriguez AL, Loch MT, Daniels JS, Lindsley CW, Hopkins CR, Javitch JA, Conn PJ
(2016) ACS Chem Neurosci 7: 1201-11
MeSH Terms: Allosteric Regulation, Animals, Antiparkinson Agents, Antipsychotic Agents, Apomorphine, Brain, Catalepsy, Disease Models, Animal, Dopamine Agonists, Forelimb, Glutamic Acid, HEK293 Cells, Haloperidol, Humans, Oxidopamine, Parkinson Disease, Rats, Rats, Sprague-Dawley, Receptors, Metabotropic Glutamate, Transfection
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and L-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist.
Iderberg H, Maslava N, Thompson AD, Bubser M, Niswender CM, Hopkins CR, Lindsley CW, Conn PJ, Jones CK, Cenci MA
(2015) Neuropharmacology 95: 121-9
MeSH Terms: Aminobutyrates, Animals, Antiparkinson Agents, Catalepsy, Dyskinesia, Drug-Induced, Excitatory Amino Acid Agents, Haloperidol, Levodopa, Male, Oxidopamine, Parkinsonian Disorders, Phosphinic Acids, Picolinic Acids, Random Allocation, Rats, Sprague-Dawley, Receptors, Metabotropic Glutamate
Added February 18, 2016
0 Communities
3 Members
0 Resources
16 MeSH Terms
The thorny problem of dyskinesias: dendritic spines, synaptic plasticity, and striatal dysfunction.
Deutch AY
(2014) Biol Psychiatry 75: 676-7
MeSH Terms: Animals, Antiparkinson Agents, Corpus Striatum, Dendritic Spines, Dyskinesia, Drug-Induced, Levodopa, Male, Neurons
Added April 6, 2017
0 Communities
1 Members
0 Resources
8 MeSH Terms
Linked clinical trials--the development of new clinical learning studies in Parkinson's disease using screening of multiple prospective new treatments.
Brundin P, Barker RA, Conn PJ, Dawson TM, Kieburtz K, Lees AJ, Schwarzschild MA, Tanner CM, Isaacs T, Duffen J, Matthews H, Wyse RK
(2013) J Parkinsons Dis 3: 231-9
MeSH Terms: Antiparkinson Agents, Clinical Trials as Topic, Humans, Parkinson Disease, Prospective Studies
Added February 19, 2015
0 Communities
1 Members
0 Resources
5 MeSH Terms
Validating an objective video-based dyskinesia severity score in Parkinson's disease patients.
Rao AS, Dawant BM, Bodenheimer RE, Li R, Fang J, Phibbs F, Hedera P, Davis T
(2013) Parkinsonism Relat Disord 19: 232-7
MeSH Terms: Antiparkinson Agents, Dyskinesia, Drug-Induced, Humans, Levodopa, Observer Variation, Parkinson Disease, Severity of Illness Index, Video Recording
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model.
Jones CK, Engers DW, Thompson AD, Field JR, Blobaum AL, Lindsley SR, Zhou Y, Gogliotti RD, Jadhav S, Zamorano R, Bogenpohl J, Smith Y, Morrison R, Daniels JS, Weaver CD, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR
(2011) J Med Chem 54: 7639-47
MeSH Terms: Administration, Oral, Allosteric Regulation, Animals, Antiparkinson Agents, Biological Availability, CHO Cells, Catalepsy, Cricetinae, Cricetulus, Haloperidol, Humans, In Vitro Techniques, Isoindoles, Microsomes, Liver, Picolinic Acids, Rats, Receptors, Metabotropic Glutamate, Structure-Activity Relationship
Added February 16, 2015
0 Communities
4 Members
0 Resources
18 MeSH Terms
Vascular endothelial growth factor is upregulated by L-dopa in the parkinsonian brain: implications for the development of dyskinesia.
Ohlin KE, Francardo V, Lindgren HS, Sillivan SE, O'Sullivan SS, Luksik AS, Vassoler FM, Lees AJ, Konradi C, Cenci MA
(2011) Brain 134: 2339-57
MeSH Terms: Aged, Aged, 80 and over, Analysis of Variance, Animals, Antigens, CD, Antigens, Surface, Antiparkinson Agents, Astrocytes, Behavior, Animal, Benserazide, Blood Vessels, Blood-Brain Barrier, Brain, Bromodeoxyuridine, Cell Count, Cells, Cultured, Disease Models, Animal, Dopamine, Dose-Response Relationship, Drug, Dyskinesia, Drug-Induced, Embryo, Mammalian, Enzyme Inhibitors, Enzyme-Linked Immunosorbent Assay, Female, Humans, Laminin, Levodopa, Male, Neovascularization, Pathologic, Nerve Tissue Proteins, Parkinsonian Disorders, RNA, Messenger, Rats, Rats, Sprague-Dawley, Time Factors, Up-Regulation, Vascular Endothelial Growth Factor A
Added May 27, 2014
0 Communities
1 Members
0 Resources
37 MeSH Terms