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Results: 1 to 10 of 37

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The antifungal drug isavuconazole inhibits the replication of human cytomegalovirus (HCMV) and acts synergistically with anti-HCMV drugs.
Mercorelli B, Celegato M, Luganini A, Gribaudo G, Lepesheva GI, Loregian A
(2021) Antiviral Res 189: 105062
MeSH Terms: Antifungal Agents, Antiviral Agents, Cell Line, Cytomegalovirus, Cytomegalovirus Infections, Drug Repositioning, Drug Resistance, Viral, Drug Synergism, Drug Therapy, Combination, Humans, Nitriles, Pyridines, Sterol 14-Demethylase, Triazoles, Virus Replication
Added July 2, 2021
0 Communities
1 Members
0 Resources
15 MeSH Terms
The Clinically Approved Antifungal Drug Posaconazole Inhibits Human Cytomegalovirus Replication.
Mercorelli B, Luganini A, Celegato M, Palù G, Gribaudo G, Lepesheva GI, Loregian A
(2020) Antimicrob Agents Chemother 64:
MeSH Terms: Antifungal Agents, Antiviral Agents, Cytomegalovirus, Cytomegalovirus Infections, Ganciclovir, Humans, Pharmaceutical Preparations, Triazoles, Virus Replication
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
A multi-institutional review of outcomes in biopsy-proven chronic invasive fungal sinusitis.
Humphreys IM, Wandell GM, Miller C, Rathor A, Schmidt RA, Turner JH, Hwang PH, Davis GE
(2020) Int Forum Allergy Rhinol 10: 738-747
MeSH Terms: Adolescent, Adult, Aged, Aged, 80 and over, Antifungal Agents, Biopsy, Child, Child, Preschool, Female, Humans, Invasive Fungal Infections, Kaplan-Meier Estimate, Leukocyte Count, Male, Middle Aged, Sinusitis, Treatment Outcome, Young Adult
Added July 23, 2020
0 Communities
1 Members
0 Resources
18 MeSH Terms
Probiotics Modulate a Novel Amphibian Skin Defense Peptide That Is Antifungal and Facilitates Growth of Antifungal Bacteria.
Woodhams DC, Rollins-Smith LA, Reinert LK, Lam BA, Harris RN, Briggs CJ, Vredenburg VT, Patel BT, Caprioli RM, Chaurand P, Hunziker P, Bigler L
(2020) Microb Ecol 79: 192-202
MeSH Terms: Amino Acid Sequence, Animals, Antifungal Agents, Chytridiomycota, Microbiota, Peptides, Probiotics, Ranidae, Skin
Added March 3, 2020
0 Communities
1 Members
0 Resources
9 MeSH Terms
The role of HLA-A*33:01 in patients with cholestatic hepatitis attributed to terbinafine.
Fontana RJ, Cirulli ET, Gu J, Kleiner D, Ostrov D, Phillips E, Schutte R, Barnhart H, Chalasani N, Watkins PB, Hoofnagle JH
(2018) J Hepatol 69: 1317-1325
MeSH Terms: Adult, Aged, Alanine Transaminase, Alkaline Phosphatase, Antifungal Agents, Biomarkers, Chemical and Drug Induced Liver Injury, Cholestasis, Female, Follow-Up Studies, HLA-A Antigens, HLA-B14 Antigen, Haplotypes, Humans, Liver, Male, Middle Aged, Molecular Docking Simulation, Polymorphism, Genetic, Prospective Studies, Protein Binding, Terbinafine
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis.
Friggeri L, Hargrove TY, Wawrzak Z, Blobaum AL, Rachakonda G, Lindsley CW, Villalta F, Nes WD, Botta M, Guengerich FP, Lepesheva GI
(2018) J Med Chem 61: 5679-5691
MeSH Terms: 14-alpha Demethylase Inhibitors, Antifungal Agents, Aspergillus fumigatus, Candida albicans, Catalytic Domain, Chemistry Techniques, Synthetic, Crystallography, X-Ray, Drug Design, Imidazoles, Ligands, Models, Molecular, Sterol 14-Demethylase
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
CYP51 as drug targets for fungi and protozoan parasites: past, present and future.
Lepesheva GI, Friggeri L, Waterman MR
(2018) Parasitology 145: 1820-1836
MeSH Terms: 14-alpha Demethylase Inhibitors, Animals, Antifungal Agents, Cytochrome P450 Family 51, Fungemia, Fungi, Humans, Models, Molecular, Parasites, Protein Binding, Substrate Specificity, Trypanosoma brucei brucei, Trypanosoma cruzi
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity.
Hargrove TY, Garvey EP, Hoekstra WJ, Yates CM, Wawrzak Z, Rachakonda G, Villalta F, Lepesheva GI
(2017) Antimicrob Agents Chemother 61:
MeSH Terms: Antifungal Agents, Aspergillus fumigatus, Candida albicans, Drugs, Investigational, Fluconazole, Ketoconazole, Microbial Sensitivity Tests, Pyridines, Sterol 14-Demethylase, Tetrazoles, Triazoles, Voriconazole
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Structural analyses of sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis.
Hargrove TY, Friggeri L, Wawrzak Z, Qi A, Hoekstra WJ, Schotzinger RJ, York JD, Guengerich FP, Lepesheva GI
(2017) J Biol Chem 292: 6728-6743
MeSH Terms: Animals, Antifungal Agents, Azoles, Candida albicans, Crystallization, Fungal Proteins, Heme, Humans, Kinetics, Ligands, Microbial Sensitivity Tests, Protein Binding, Protein Conformation, Protons, Rats, Sterol 14-Demethylase, Sterols
Added March 14, 2018
0 Communities
3 Members
0 Resources
17 MeSH Terms
Congenital Cutaneous Candidiasis: Prompt Systemic Treatment Is Associated With Improved Outcomes in Neonates.
Kaufman DA, Coggins SA, Zanelli SA, Weitkamp JH
(2017) Clin Infect Dis 64: 1387-1395
MeSH Terms: Adolescent, Adult, Antifungal Agents, Candida, Candidiasis, Candidiasis, Cutaneous, Drug Administration Routes, Female, Gestational Age, Humans, Infant, Newborn, Infant, Premature, Diseases, Intensive Care Units, Neonatal, Male, Medical Records, Nystatin, Pregnancy, Skin, Treatment Outcome, Young Adult
Added April 16, 2021
0 Communities
1 Members
0 Resources
MeSH Terms