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Results: 1 to 9 of 9

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An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions.
Kinder M, Greenplate AR, Strohl WR, Jordan RE, Brezski RJ
(2015) MAbs 7: 494-504
MeSH Terms: Antibodies, Monoclonal, Antibodies, Neoplasm, Antibody-Dependent Cell Cytotoxicity, Cell Line, Tumor, Cytokines, Humans, Immunoglobulin Fc Fragments, Macrophages, Neoplasms, Protein Engineering, Tumor Microenvironment
Added April 22, 2016
0 Communities
1 Members
0 Resources
11 MeSH Terms
A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo.
Brezski RJ, Kinder M, Grugan KD, Soring KL, Carton J, Greenplate AR, Petley T, Capaldi D, Brosnan K, Emmell E, Watson S, Jordan RE
(2014) MAbs 6: 1265-73
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Monoclonal, Murine-Derived, Antibody-Dependent Cell Cytotoxicity, Bacterial Proteins, Blood Platelets, Cell Line, Cell Line, Tumor, Cysteine Endopeptidases, Dogs, Enzyme-Linked Immunosorbent Assay, Epitopes, Humans, Immunoglobulin Fab Fragments, Immunoglobulin G, Matrix Metalloproteinase 3, Platelet Count, Proteolysis, Rats, Rituximab
Added April 22, 2016
0 Communities
1 Members
0 Resources
20 MeSH Terms
Engineered protease-resistant antibodies with selectable cell-killing functions.
Kinder M, Greenplate AR, Grugan KD, Soring KL, Heeringa KA, McCarthy SG, Bannish G, Perpetua M, Lynch F, Jordan RE, Strohl WR, Brezski RJ
(2013) J Biol Chem 288: 30843-54
MeSH Terms: Antibodies, Monoclonal, Antibody-Dependent Cell Cytotoxicity, Binding Sites, Antibody, Cell Line, Humans, Immunoglobulin G, Protein Engineering, Proteolysis, Receptors, IgG
Added March 27, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy.
Fan X, Brezski RJ, Fa M, Deng H, Oberholtzer A, Gonzalez A, Dubinsky WP, Strohl WR, Jordan RE, Zhang N, An Z
(2012) Breast Cancer Res 14: R116
MeSH Terms: Amino Acid Sequence, Animals, Antibodies, Monoclonal, Humanized, Antibody-Dependent Cell Cytotoxicity, Cell Line, Disease Models, Animal, Female, Humans, Matrix Metalloproteinases, Mice, Molecular Sequence Data, Neoplasms, Protein Binding, Proteolysis, Receptor, ErbB-2, Receptors, IgG, Trastuzumab, Xenograft Model Antitumor Assays
Added March 27, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge.
Brezski RJ, Oberholtzer A, Strake B, Jordan RE
(2011) MAbs 3: 558-67
MeSH Terms: Amino Acid Sequence, Antibodies, Monoclonal, Antibody-Dependent Cell Cytotoxicity, Autoantibodies, Complement System Proteins, Hinge Exons, Humans, Immunoglobulin G, Macrophages, Molecular Sequence Data, Peptide Hydrolases, Peptides, Phagocytosis
Added March 27, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge.
Brezski RJ, Vafa O, Petrone D, Tam SH, Powers G, Ryan MH, Luongo JL, Oberholtzer A, Knight DM, Jordan RE
(2009) Proc Natl Acad Sci U S A 106: 17864-9
MeSH Terms: Animals, Antibodies, Monoclonal, Antibody Affinity, Antibody-Dependent Cell Cytotoxicity, Bacterial Proteins, Binding Sites, Breast Neoplasms, Cell Membrane, Female, Humans, Immunoglobulin Fragments, Immunoglobulin G, In Vitro Techniques, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Peptide Hydrolases, Rats, Receptors, IgG, Serine Endopeptidases, Staphylococcus aureus, Streptococcus pyogenes
Added March 27, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
Natural cytotoxicity and antibody-dependent cellular cytotoxicity of human lymphocytes depleted of HLA-DR bearing cells with monoclonal HLA-DR antibodies.
Ng AK, Indiveri F, Pellegrino MA, Molinaro GA, Quaranta V, Ferrone S
(1980) J Immunol 124: 2336-40
MeSH Terms: Animals, Antibodies, Antibody-Dependent Cell Cytotoxicity, Cell Adhesion, Cytotoxicity, Immunologic, Erythrocytes, HLA Antigens, Humans, Lymphocytes, Rosette Formation, Sheep, beta-Aminoethyl Isothiourea
Added March 27, 2014
1 Communities
1 Members
0 Resources
12 MeSH Terms
Characterization of human null cells isolated from peripheral lymphocytes by a simultaneous double-rosetting procedure.
Ng AK, Indiveri F, Russo C, Quaranta V, Pellegrino MA, Ferrone S
(1981) Scand J Immunol 14: 225-31
MeSH Terms: Antibody-Dependent Cell Cytotoxicity, B-Lymphocytes, Cell Separation, Erythrocytes, Humans, Killer Cells, Natural, Lymphocyte Activation, Lymphocyte Culture Test, Mixed, Lymphocyte Depletion, Lymphocytes, Null, Phytohemagglutinins, Receptors, Antigen, B-Cell, Rosette Formation, T-Lymphocytes
Added March 27, 2014
1 Communities
1 Members
0 Resources
14 MeSH Terms
Isolation of Ia-like antigen-bearing cells from human peripheral lymphocytes through the use of a monoclonal antibody to framework determinants of Ia-like antigens.
Indiveri F, Ng AK, Russo C, Quaranta V, Pellegrino MA, Ferrone S
(1980) J Immunol Methods 39: 343-54
MeSH Terms: Animals, Antibodies, Antibody-Dependent Cell Cytotoxicity, B-Lymphocytes, Cell Separation, Clone Cells, Complement System Proteins, Cytotoxicity, Immunologic, Epitopes, Goats, HLA Antigens, Histocompatibility Antigens Class II, Humans, Lymphocyte Culture Test, Mixed, Lymphocytes, Mice, Rabbits, Rosette Formation, Sheep, T-Lymphocytes
Added March 27, 2014
1 Communities
1 Members
0 Resources
20 MeSH Terms