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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 22

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Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein.
Sangha AK, Dong J, Williamson L, Hashiguchi T, Saphire EO, Crowe JE, Meiler J
(2017) Structure 25: 1820-1828.e2
MeSH Terms: Antibodies, Monoclonal, Antibodies, Neutralizing, Antibody Affinity, Binding Sites, Antibody, Molecular Docking Simulation, Protein Binding, Viral Envelope Proteins
Added March 14, 2018
0 Communities
2 Members
0 Resources
7 MeSH Terms
Antibody recognition of the pandemic H1N1 Influenza virus hemagglutinin receptor binding site.
Hong M, Lee PS, Hoffman RM, Zhu X, Krause JC, Laursen NS, Yoon SI, Song L, Tussey L, Crowe JE, Ward AB, Wilson IA
(2013) J Virol 87: 12471-80
MeSH Terms: Antibodies, Viral, Antibody Affinity, Antigens, Viral, Binding Sites, Antibody, Crystallography, X-Ray, Hemagglutinin Glycoproteins, Influenza Virus, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human, Models, Molecular, Pandemics, Protein Conformation, Receptors, Virus, United States
Added March 7, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Reversion of somatic mutations of the respiratory syncytial virus-specific human monoclonal antibody Fab19 reveal a direct relationship between association rate and neutralizing potency.
Bates JT, Keefer CJ, Utley TJ, Correia BE, Schief WR, Crowe JE
(2013) J Immunol 190: 3732-9
MeSH Terms: Amino Acid Sequence, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Antibody Affinity, Antibody Specificity, Humans, Immunoglobulin Fab Fragments, Immunoglobulin Variable Region, Kinetics, Models, Molecular, Molecular Docking Simulation, Mutation, Neutralization Tests, Protein Binding, Protein Conformation, Recombinant Proteins, Respiratory Syncytial Virus, Human, Viral Fusion Proteins
Added March 7, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Influenza human monoclonal antibody 1F1 interacts with three major antigenic sites and residues mediating human receptor specificity in H1N1 viruses.
Tsibane T, Ekiert DC, Krause JC, Martinez O, Crowe JE, Wilson IA, Basler CF
(2012) PLoS Pathog 8: e1003067
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Viral, Antibody Affinity, Binding Sites, Antibody, Crystallography, X-Ray, Epitopes, Hemagglutinin Glycoproteins, Influenza Virus, Humans, Immunoglobulin Heavy Chains, Influenza A Virus, H1N1 Subtype, Mice, Mutagenesis, Site-Directed, Protein Structure, Quaternary
Added January 26, 2016
0 Communities
1 Members
0 Resources
14 MeSH Terms
An HLA-presented fragment of macrophage migration inhibitory factor is a therapeutic target for invasive breast cancer.
Hawkins O, Verma B, Lightfoot S, Jain R, Rawat A, McNair S, Caseltine S, Mojsilovic A, Gupta P, Neethling F, Almanza O, Dooley W, Hildebrand W, Weidanz J
(2011) J Immunol 186: 6607-16
MeSH Terms: Amino Acid Sequence, Animals, Antibodies, Monoclonal, Antibody Affinity, Antibody Specificity, Apoptosis, Breast Neoplasms, Carcinoma, Ductal, Breast, Cell Line, Cell Line, Tumor, Cell Survival, Dose-Response Relationship, Drug, Female, HLA-A Antigens, HLA-A2 Antigen, Humans, Kinetics, Macrophage Migration-Inhibitory Factors, Mice, Mice, Nude, Peptides, Prognosis, Protein Binding, Xenograft Model Antitumor Assays
Added May 31, 2013
0 Communities
1 Members
0 Resources
24 MeSH Terms
Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge.
Brezski RJ, Vafa O, Petrone D, Tam SH, Powers G, Ryan MH, Luongo JL, Oberholtzer A, Knight DM, Jordan RE
(2009) Proc Natl Acad Sci U S A 106: 17864-9
MeSH Terms: Animals, Antibodies, Monoclonal, Antibody Affinity, Antibody-Dependent Cell Cytotoxicity, Bacterial Proteins, Binding Sites, Breast Neoplasms, Cell Membrane, Female, Humans, Immunoglobulin Fragments, Immunoglobulin G, In Vitro Techniques, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Peptide Hydrolases, Rats, Receptors, IgG, Serine Endopeptidases, Staphylococcus aureus, Streptococcus pyogenes
Added March 27, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
Hemagglutinin linear epitope presentation on monolayer-protected clusters elicits strong antibody binding.
Gerdon AE, Wright DW, Cliffel DE
(2005) Biomacromolecules 6: 3419-24
MeSH Terms: Adsorption, Antibodies, Antibodies, Monoclonal, Antibody Affinity, Antigen Presentation, Antigen-Antibody Reactions, Binding Sites, Antibody, Crystallization, Dose-Response Relationship, Drug, Epitopes, Hemagglutinin Glycoproteins, Influenza Virus, Hemagglutinins, Hemagglutinins, Viral, Humans, Immunoassay, Immunoglobulin G, Immunoglobulins, Indicators and Reagents, Influenza Vaccines, Kinetics, Nanostructures, Peptides, Time Factors, Water
Added January 20, 2015
0 Communities
1 Members
0 Resources
24 MeSH Terms
Phosphorylation-status of phospholamban and calsequestrin modifies their affinity towards commonly used antibodies.
Huke S, Periasamy M
(2004) J Mol Cell Cardiol 37: 795-9
MeSH Terms: Animals, Antibodies, Antibody Affinity, Binding Sites, Antibody, Blotting, Western, Calcium-Binding Proteins, Calsequestrin, Mice, Myocardium, Phosphorylation, Sarcoplasmic Reticulum
Added May 27, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
The in vitro and in vivo effects of anti-galactose antibodies on endothelial cell activation and xenograft rejection.
Xu H, Yin D, Naziruddin B, Chen L, Stark A, Wei Y, Lei Y, Shen J, Logan JS, Byrne GW, Chong AS
(2003) J Immunol 170: 1531-9
MeSH Terms: Animals, Antibodies, Monoclonal, Antibody Affinity, Apoptosis, Binding Sites, Antibody, Cell Line, DNA-Binding Proteins, Disaccharides, Endothelium, Vascular, Erythrocytes, Graft Rejection, Heart Transplantation, Humans, Hybridomas, Injections, Intravenous, Mice, Mice, Knockout, Nuclear Proteins, Rats, Rats, Inbred Lew, Swine, Transplantation, Heterologous, Transplantation, Heterotopic
Added December 10, 2013
0 Communities
1 Members
0 Resources
23 MeSH Terms
Genetic and structural determinants of virus neutralizing antibodies.
Crowe JE, Suara RO, Brock S, Kallewaard N, House F, Weitkamp JH
(2001) Immunol Res 23: 135-45
MeSH Terms: Antibodies, Viral, Antibody Affinity, Antibody Diversity, Antigens, Viral, Cell Polarity, Epitopes, Evolution, Molecular, Genes, Immunoglobulin, Humans, Immunity, Innate, Immunoglobulin Fab Fragments, Immunoglobulin Isotypes, Immunoglobulin Variable Region, Immunologic Techniques, Mucous Membrane, Neutralization Tests, Respiratory Syncytial Viruses, Structure-Activity Relationship, Virion, Virus Replication
Added February 27, 2014
0 Communities
2 Members
0 Resources
20 MeSH Terms