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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 58

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Collagen IV dysfunction in glomerular basement membrane diseases. I. Discovery of a COL4A3 variant in familial Goodpasture's and Alport diseases.
Pokidysheva EN, Seeger H, Pedchenko V, Chetyrkin S, Bergmann C, Abrahamson D, Cui ZW, Delpire E, Fervenza FC, Fidler AL, Fogo AB, Gaspert A, Grohmann M, Gross O, Haddad G, Harris RC, Kashtan C, Kitching AR, Lorenzen JM, McAdoo S, Pusey CD, Segelmark M, Simmons A, Voziyan PA, Wagner T, Wüthrich RP, Zhao MH, Boudko SP, Kistler AD, Hudson BG
(2021) J Biol Chem 296: 100590
MeSH Terms: Animals, Anti-Glomerular Basement Membrane Disease, Collagen Type IV, Mice, Models, Molecular, Mutation, Nephritis, Hereditary, Protein Multimerization, Protein Structure, Quaternary, Signal Transduction
Added September 3, 2021
1 Communities
0 Members
0 Resources
MeSH Terms
Inhibitory Anti-Peroxidasin Antibodies in Pulmonary-Renal Syndromes.
McCall AS, Bhave G, Pedchenko V, Hess J, Free M, Little DJ, Baker TP, Pendergraft WF, Falk RJ, Olson SW, Hudson BG
(2018) J Am Soc Nephrol 29: 2619-2625
MeSH Terms: Adolescent, Adult, Aged, Aged, 80 and over, Anti-Glomerular Basement Membrane Disease, Antibodies, Antineutrophil Cytoplasmic, Antibody Specificity, Autoantibodies, Autoantigens, Child, Cohort Studies, Collagen Type IV, Extracellular Matrix Proteins, Female, Glomerulonephritis, Hemorrhage, Humans, Lung Diseases, Male, Middle Aged, Models, Immunological, Peroxidase, Peroxidases, Young Adult
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.
Ooi JD, Petersen J, Tan YH, Huynh M, Willett ZJ, Ramarathinam SH, Eggenhuizen PJ, Loh KL, Watson KA, Gan PY, Alikhan MA, Dudek NL, Handel A, Hudson BG, Fugger L, Power DA, Holt SG, Coates PT, Gregersen JW, Purcell AW, Holdsworth SR, La Gruta NL, Reid HH, Rossjohn J, Kitching AR
(2017) Nature 545: 243-247
MeSH Terms: Animals, Anti-Glomerular Basement Membrane Disease, Autoimmunity, Base Sequence, CD4-Positive T-Lymphocytes, Collagen Type IV, Cytokines, Female, Forkhead Transcription Factors, HLA-DR Serological Subtypes, HLA-DR1 Antigen, Humans, Immunodominant Epitopes, Male, Mice, Mice, Transgenic, Models, Molecular, T-Lymphocytes, Regulatory
Added June 2, 2017
1 Communities
1 Members
0 Resources
18 MeSH Terms
The susceptible HLA class II alleles and their presenting epitope(s) in Goodpasture's disease.
Xie LJ, Cui Z, Chen FJ, Pei ZY, Hu SY, Gu QH, Jia XY, Zhu L, Zhou XJ, Zhang H, Liao YH, Lai LH, Hudson BG, Zhao MH
(2017) Immunology 151: 395-404
MeSH Terms: Alleles, Anti-Glomerular Basement Membrane Disease, Autoantigens, China, Collagen Type IV, Computer Simulation, Epitope Mapping, Epitopes, T-Lymphocyte, Genetic Predisposition to Disease, Genotype, HLA-DRB1 Chains, Humans, Polymorphism, Genetic, Protein Binding, Protein Conformation, Receptors, Antigen, T-Cell, Risk, T-Lymphocytes
Added May 12, 2017
1 Communities
1 Members
1 Resources
18 MeSH Terms
Antibodies to α5 chain of collagen IV are pathogenic in Goodpasture's disease.
Cui Z, Zhao MH, Jia XY, Wang M, Hu SY, Wang SX, Yu F, Brown KL, Hudson BG, Pedchenko V
(2016) J Autoimmun 70: 1-11
MeSH Terms: Aged, Amino Acid Sequence, Animals, Anti-Glomerular Basement Membrane Disease, Autoantibodies, Autoantigens, Autoimmunity, Biopsy, Case-Control Studies, Cell Line, Tumor, Collagen Type IV, Disease Models, Animal, Epitope Mapping, Epitopes, Female, Humans, Kidney Glomerulus, Male, Models, Molecular, Protein Conformation, Protein Subunits, Rats, Rats, Inbred WKY
Added June 14, 2016
1 Communities
1 Members
1 Resources
23 MeSH Terms
IgG4-restricted anti-glomerular basement membrane autoantibodies targeting quaternary epitopes of native α345(IV) collagen.
Borza DB
(2014) Am J Kidney Dis 64: 156-7
MeSH Terms: Anti-Glomerular Basement Membrane Disease, Autoantibodies, Female, Humans, Immunoglobulin G
Added December 2, 2016
1 Communities
1 Members
0 Resources
5 MeSH Terms
Neonatal Fc receptor promotes immune complex-mediated glomerular disease.
Olaru F, Luo W, Suleiman H, St John PL, Ge L, Mezo AR, Shaw AS, Abrahamson DR, Miner JH, Borza DB
(2014) J Am Soc Nephrol 25: 918-25
MeSH Terms: Albuminuria, Animals, Anti-Glomerular Basement Membrane Disease, Antigen-Antibody Complex, Autoantigens, Collagen Type IV, Glomerulonephritis, HEK293 Cells, Histocompatibility Antigens Class I, Humans, Immunoglobulin G, Male, Mice, Mice, Inbred C57BL, Receptors, Fc
Added December 2, 2016
1 Communities
1 Members
0 Resources
15 MeSH Terms
Quaternary epitopes of α345(IV) collagen initiate Alport post-transplant anti-GBM nephritis.
Olaru F, Luo W, Wang XP, Ge L, Hertz JM, Kashtan CE, Sado Y, Segal Y, Hudson BG, Borza DB
(2013) J Am Soc Nephrol 24: 889-95
MeSH Terms: Animals, Anti-Glomerular Basement Membrane Disease, Autoantigens, Basement Membrane, Cattle, Collagen Type IV, Epitope Mapping, Haplorhini, Humans, Immunoglobulin G, Isoantibodies, Kidney Glomerulus, Kidney Transplantation, Mice, Mice, Transgenic, Nephritis, Hereditary, Postoperative Complications, Protein Interaction Domains and Motifs, Protein Structure, Quaternary, Transplantation, Homologous
Added August 21, 2013
1 Communities
2 Members
0 Resources
20 MeSH Terms
The HLA-DRB1*15:01-restricted Goodpasture's T cell epitope induces GN.
Ooi JD, Chang J, O'Sullivan KM, Pedchenko V, Hudson BG, Vandenbark AA, Fugger L, Holdsworth SR, Kitching AR
(2013) J Am Soc Nephrol 24: 419-31
MeSH Terms: Amino Acid Sequence, Animals, Anti-Glomerular Basement Membrane Disease, Autoantigens, Autoimmunity, Collagen Type IV, Disease Models, Animal, Epitopes, T-Lymphocyte, HLA-DRB1 Chains, Humans, Immunization, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Molecular Sequence Data, Receptors, IgG, Recombinant Fusion Proteins
Added August 27, 2013
1 Communities
2 Members
0 Resources
18 MeSH Terms
Proteolysis breaks tolerance toward intact α345(IV) collagen, eliciting novel anti-glomerular basement membrane autoantibodies specific for α345NC1 hexamers.
Olaru F, Wang XP, Luo W, Ge L, Miner JH, Kleinau S, Geiger XJ, Wasiluk A, Heidet L, Kitching AR, Borza DB
(2013) J Immunol 190: 1424-32
MeSH Terms: Animals, Anti-Glomerular Basement Membrane Disease, Antibody Specificity, Autoantibodies, Autoantigens, Collagen Type IV, Disease Models, Animal, Epitopes, Female, HEK293 Cells, Humans, Immune Tolerance, Immunoglobulin G, Male, Mice, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Knockout, Mice, Transgenic, Proteolysis
Added August 21, 2013
1 Communities
1 Members
0 Resources
20 MeSH Terms