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Cyclooxygenase-2 deficiency attenuates lipopolysaccharide-induced inflammation, apoptosis, and acute lung injury in adult mice.
Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J
(2022) Am J Physiol Regul Integr Comp Physiol 322: R126-R135
MeSH Terms: Acute Lung Injury, Animals, Apoptosis, Caspase 3, Caspase 9, Chemokine CCL2, Cyclooxygenase 2, Disease Models, Animal, Female, Interleukin-10, Lipopolysaccharides, Lung, Male, Mice, Knockout, Pneumonia, Signal Transduction, Tumor Necrosis Factor-alpha
Added February 1, 2022
0 Communities
1 Members
0 Resources
17 MeSH Terms
DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3.
Borza CM, Bolas G, Bock F, Zhang X, Akabogu FC, Zhang MZ, de Caestecker M, Yang M, Yang H, Lee E, Gewin L, Fogo AB, McDonald WH, Zent R, Pozzi A
(2022) JCI Insight 7:
MeSH Terms: Acute Kidney Injury, Animals, Cell Line, Cells, Cultured, Discoidin Domain Receptor 1, Female, Fibrosis, Gene Expression Regulation, Inflammation, Kidney Tubules, Proximal, Male, Mice, Mice, Knockout, Phosphorylation, Proto-Oncogene Proteins c-bcr, RNA, STAT3 Transcription Factor, Signal Transduction
Added December 27, 2021
0 Communities
1 Members
0 Resources
18 MeSH Terms
Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots.
Trogden KP, Lee J, Bracey KM, Ho KH, McKinney H, Zhu X, Arpag G, Folland TG, Osipovich AB, Magnuson MA, Zanic M, Gu G, Holmes WR, Kaverina I
(2021) Elife 10:
MeSH Terms: Animals, Female, Insulin, Insulin Secretion, Insulin-Secreting Cells, Male, Mice, Microtubules, Spatio-Temporal Analysis
Added December 7, 2021
1 Communities
0 Members
0 Resources
9 MeSH Terms
Protective Role of Spermidine in Colitis and Colon Carcinogenesis.
Gobert AP, Latour YL, Asim M, Barry DP, Allaman MM, Finley JL, Smith TM, McNamara KM, Singh K, Sierra JC, Delgado AG, Luis PB, Schneider C, Washington MK, Piazuelo MB, Zhao S, Coburn LA, Wilson KT
(2022) Gastroenterology 162: 813-827.e8
MeSH Terms: Adenomatous Polyposis Coli Protein, Animals, Azoxymethane, Carcinogenesis, Colitis, Colitis, Ulcerative, Colon, Colonic Neoplasms, Dextran Sulfate, Gastrointestinal Microbiome, Gene Expression Regulation, Humans, Intestinal Mucosa, Male, Mice, Oxidoreductases Acting on CH-NH Group Donors, Precancerous Conditions, Protective Factors, RNA, Messenger, Severity of Illness Index, Spermidine, Weight Loss, alpha-Defensins
Added November 18, 2021
0 Communities
1 Members
0 Resources
23 MeSH Terms
CD36 maintains the gastric mucosa and associates with gastric disease.
Jacome-Sosa M, Miao ZF, Peche VS, Morris EF, Narendran R, Pietka KM, Samovski D, Lo HG, Pietka T, Varro A, Love-Gregory L, Goldenring JR, Kuda O, Gamazon ER, Mills JC, Abumrad NA
(2021) Commun Biol 4: 1247
MeSH Terms: Animals, CD36 Antigens, Endothelial Cells, Female, Gastric Mucosa, Gastritis, Gastrointestinal Hemorrhage, Male, Mice, Mice, Inbred C57BL, Stomach Ulcer
Added November 24, 2021
0 Communities
1 Members
0 Resources
11 MeSH Terms
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh HW, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, Birsoy K
(2021) Nature 599: 136-140
MeSH Terms: Animals, Biological Transport, Cell Proliferation, Cells, Cultured, Erythropoiesis, Glutathione, Homeostasis, Humans, Iron-Sulfur Proteins, Mice, Mitochondria, Mitochondrial Membrane Transport Proteins, Oxidation-Reduction, Proteome, Proteomics
Added October 29, 2021
0 Communities
1 Members
0 Resources
15 MeSH Terms
Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males.
Walker EM, Cha J, Tong X, Guo M, Liu JH, Yu S, Iacovazzo D, Mauvais-Jarvis F, Flanagan SE, Korbonits M, Stafford J, Jacobson DA, Stein R
(2021) Cell Rep 37: 109813
MeSH Terms: Animals, Animals, Genetically Modified, Blood Glucose, Calcium Signaling, Cell Line, Cellular Senescence, DNA Damage, Diabetes Mellitus, Type 2, Disease Models, Animal, Female, Genetic Predisposition to Disease, Humans, Insulin, Insulin-Secreting Cells, Maf Transcription Factors, Large, Male, Mice, Inbred C57BL, Mutation, Missense, Phenotype, Sex Characteristics, Sex Factors
Added November 23, 2021
0 Communities
1 Members
0 Resources
21 MeSH Terms
CCL11 exacerbates colitis and inflammation-associated colon tumorigenesis.
Polosukhina D, Singh K, Asim M, Barry DP, Allaman MM, Hardbower DM, Piazuelo MB, Washington MK, Gobert AP, Wilson KT, Coburn LA
(2021) Oncogene 40: 6540-6546
MeSH Terms: Animals, Azoxymethane, Carcinogenesis, Carcinogens, Chemokine CCL11, Colitis, Colitis-Associated Neoplasms, Epithelial Cells, Mice, Mice, Knockout
Added October 10, 2021
0 Communities
1 Members
0 Resources
10 MeSH Terms
Insm1, Neurod1, and Pax6 promote murine pancreatic endocrine cell development through overlapping yet distinct RNA transcription and splicing programs.
Dudek KD, Osipovich AB, Cartailler JP, Gu G, Magnuson MA
(2021) G3 (Bethesda) 11:
MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Cell Differentiation, Endocrine Cells, Eye Proteins, Gene Expression Regulation, Developmental, Homeodomain Proteins, Mice, PAX6 Transcription Factor, RNA, RNA Splicing, Repressor Proteins, Transcription Factors
Added September 24, 2021
2 Communities
2 Members
0 Resources
13 MeSH Terms
The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling.
Shen C, Nayak A, Neitzel LR, Adams AA, Silver-Isenstadt M, Sawyer LM, Benchabane H, Wang H, Bunnag N, Li B, Wynn DT, Yang F, Garcia-Contreras M, Williams CH, Dakshanamurthy S, Hong CC, Ayad NG, Capobianco AJ, Ahmed Y, Lee E, Robbins DJ
(2021) Nat Commun 12: 5263
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Casein Kinase Ialpha, Drosophila Proteins, Drosophila melanogaster, Embryo, Nonmammalian, Evolution, Molecular, HEK293 Cells, Humans, Immunologic Factors, Lenalidomide, Mice, Organoids, Peptide Hydrolases, Ubiquitin-Protein Ligases, Ubiquitination, Wnt Signaling Pathway, Zebrafish, Zebrafish Proteins
Added September 11, 2021
0 Communities
1 Members
0 Resources
19 MeSH Terms