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Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.
Gonzalez E, Guengerich FP
(2017) J Biol Chem 292: 13168-13185
MeSH Terms: 17-alpha-Hydroxypregnenolone, Androstenedione, Animals, Binding Sites, Biocatalysis, Cytochrome P-450 Enzyme Inhibitors, Cytochromes b5, Dehydroepiandrosterone, Humans, Imidazoles, Kinetics, Ligands, Models, Molecular, NADPH-Ferrihemoprotein Reductase, Naphthalenes, Oxidation-Reduction, Pregnenolone, Progesterone, Protein Conformation, Rats, Recombinant Proteins, Stereoisomerism, Steroid 17-alpha-Hydroxylase
Added March 14, 2018
0 Communities
1 Members
0 Resources
23 MeSH Terms
Kinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1.
Sohl CD, Guengerich FP
(2010) J Biol Chem 285: 17734-43
MeSH Terms: Amino Acid Sequence, Androstenedione, Animals, Aromatase, Cytochrome P-450 Enzyme System, Estrone, Humans, Iron, Kinetics, Models, Chemical, Molecular Sequence Data, Protein Binding, Protein Structure, Tertiary, Rats, Steroids
Added March 7, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
The ferrous-oxy complex of human aromatase.
Grinkova YV, Denisov IG, Waterman MR, Arase M, Kagawa N, Sligar SG
(2008) Biochem Biophys Res Commun 372: 379-82
MeSH Terms: Androstenedione, Aromatase, Humans, Iron, Lipid Bilayers, Nanostructures, Oxidation-Reduction, Phospholipids
Added February 12, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms
Raman evidence for specific substrate-induced structural changes in the heme pocket of human cytochrome P450 aromatase during the three consecutive oxygen activation steps.
Tosha T, Kagawa N, Ohta T, Yoshioka S, Waterman MR, Kitagawa T
(2006) Biochemistry 45: 5631-40
MeSH Terms: Androstenedione, Aromatase, Carbon Monoxide, Ferrous Compounds, Heme, Humans, Models, Chemical, Oxygen, Spectrophotometry, Spectrum Analysis, Raman
Added February 12, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
ErbB receptor signaling and therapeutic resistance to aromatase inhibitors.
Shin I, Miller T, Arteaga CL
(2006) Clin Cancer Res 12: 1008s-1012s
MeSH Terms: Acetyltransferases, Androstenedione, Aromatase Inhibitors, Breast Neoplasms, Carrier Proteins, Cell Line, Tumor, Corticosterone, Drug Resistance, Neoplasm, Female, Histone Acetyltransferases, Humans, Letrozole, Nitriles, Nuclear Receptor Coactivator 3, Oncogene Proteins, Promoter Regions, Genetic, Receptor, ErbB-2, Receptors, Estrogen, Signal Transduction, Trans-Activators, Transcriptional Activation, Triazoles
Added March 5, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
Characterization of stable human aromatase expressed in E. coli.
Kagawa N, Hori H, Waterman MR, Yoshioka S
(2004) Steroids 69: 235-43
MeSH Terms: Amino Acid Sequence, Androstenedione, Arginine, Aromatase, Aromatase Inhibitors, Cell Membrane, Chaperonin 10, Chaperonin 60, Chloramphenicol, Cysteine, Electron Spin Resonance Spectroscopy, Enzyme Stability, Escherichia coli, Estradiol, Estrone, Fadrozole, Gene Expression, Humans, Letrozole, Molecular Sequence Data, Nitriles, Polymorphism, Genetic, Protein Structure, Secondary, Protein Synthesis Inhibitors, Recombinant Proteins, Solubility, Testosterone, Triazoles
Added February 12, 2015
0 Communities
1 Members
0 Resources
28 MeSH Terms
Premature pubarche in girls is associated with functional adrenal but not ovarian hyperandrogenism.
Mathew RP, Najjar JL, Lorenz RA, Mayes DE, Russell WE
(2002) J Pediatr 141: 91-8
MeSH Terms: 17-alpha-Hydroxyprogesterone, Adrenal Cortex, Androstenedione, Biomarkers, Case-Control Studies, Child, Child, Preschool, Dehydroepiandrosterone, Estradiol, Female, Hirsutism, Humans, Hyperandrogenism, Immunoenzyme Techniques, Ovary, Statistics, Nonparametric, Steroids
Added December 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
Androgens and masculinization of genitalia in the spotted hyaena (Crocuta crocuta). 1. Urogenital morphology and placental androgen production during fetal life.
Licht P, Hayes T, Tsai P, Cunha G, Kim H, Golbus M, Hayward S, Martin MC, Jaffe RB, Glickman SE
(1998) J Reprod Fertil 113: 105-16
MeSH Terms: Androgens, Androstenedione, Animals, Carnivora, Clitoris, Female, Gestational Age, Male, Mesonephros, Mullerian Ducts, Ovary, Placenta, Sex Differentiation, Testis, Urethra, Urogenital System, Wolffian Ducts
Added May 27, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.
Katagiri M, Kagawa N, Waterman MR
(1995) Arch Biochem Biophys 317: 343-7
MeSH Terms: 17-alpha-Hydroxypregnenolone, 17-alpha-Hydroxyprogesterone, Aldehyde-Lyases, Androgens, Androstenedione, Cell Membrane, Cytochrome P-450 Enzyme System, Cytochromes b5, Dehydroepiandrosterone, Escherichia coli, Humans, Hydroxyprogesterones, Kinetics, Pregnenolone, Progesterone, Recombinant Proteins, Steroid 17-alpha-Hydroxylase
Added February 12, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Effects of ACTH on steroidogenesis in bovine adrenocortical cells in primary culture--increased secretion of 17 alpha-hydroxylated steroids associated with a refractoriness in total steroid output.
Kramer RE, McCarthy JL, Simpson ER, Waterman MR
(1983) J Steroid Biochem 18: 715-23
MeSH Terms: Adrenal Cortex, Adrenal Cortex Hormones, Adrenocorticotropic Hormone, Androstenedione, Animals, Cattle, Cells, Cultured, Corticosterone, Dehydroepiandrosterone, Hydrocortisone, Hydroxycorticosteroids, Kinetics, Progesterone
Added February 12, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms