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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 26

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Transfer of Functional Cargo in Exomeres.
Zhang Q, Higginbotham JN, Jeppesen DK, Yang YP, Li W, McKinley ET, Graves-Deal R, Ping J, Britain CM, Dorsett KA, Hartman CL, Ford DA, Allen RM, Vickers KC, Liu Q, Franklin JL, Bellis SL, Coffey RJ
(2019) Cell Rep 27: 940-954.e6
MeSH Terms: Amphiregulin, Animals, Cell Line, Tumor, Colonic Neoplasms, Dogs, ErbB Receptors, Exosomes, Humans, Lipids, Madin Darby Canine Kidney Cells, Mice, Mice, Knockout, Nanoparticles, Nucleic Acids, Particle Size, Principal Component Analysis, Proteome, Proteomics, Sialyltransferases
Added April 24, 2019
1 Communities
1 Members
0 Resources
19 MeSH Terms
A Chimeric Egfr Protein Reporter Mouse Reveals Egfr Localization and Trafficking In Vivo.
Yang YP, Ma H, Starchenko A, Huh WJ, Li W, Hickman FE, Zhang Q, Franklin JL, Mortlock DP, Fuhrmann S, Carter BD, Ihrie RA, Coffey RJ
(2017) Cell Rep 19: 1257-1267
MeSH Terms: Adult Stem Cells, Amphiregulin, Animals, Embryo, Mammalian, ErbB Receptors, Genes, Reporter, Green Fluorescent Proteins, Hepatocytes, Intestinal Mucosa, Mice, Microscopy, Fluorescence, Protein Transport, Recombinant Proteins, Transgenes
Added June 21, 2017
1 Communities
5 Members
2 Resources
14 MeSH Terms
Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer.
Young CD, Zimmerman LJ, Hoshino D, Formisano L, Hanker AB, Gatza ML, Morrison MM, Moore PD, Whitwell CA, Dave B, Stricker T, Bhola NE, Silva GO, Patel P, Brantley-Sieders DM, Levin M, Horiates M, Palma NA, Wang K, Stephens PJ, Perou CM, Weaver AM, O'Shaughnessy JA, Chang JC, Park BH, Liebler DC, Cook RS, Arteaga CL
(2015) Mol Cell Proteomics 14: 1959-76
MeSH Terms: Amphiregulin, Animals, Breast Neoplasms, Cell Line, Tumor, Cell Proliferation, Chromatography, Liquid, Class I Phosphatidylinositol 3-Kinases, Disease-Free Survival, Down-Regulation, Epidermal Growth Factor, ErbB Receptors, Extracellular Matrix, Extracellular Signal-Regulated MAP Kinases, Female, Humans, Mice, Nude, Mutation, Neoplasm Proteins, Paracrine Communication, Phosphatidylinositol 3-Kinases, Protein Binding, Protein Kinase Inhibitors, Proteomics, Signal Transduction, Tandem Mass Spectrometry, Up-Regulation
Added February 15, 2016
1 Communities
3 Members
0 Resources
26 MeSH Terms
Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids.
Nagathihalli NS, Beesetty Y, Lee W, Washington MK, Chen X, Lockhart AC, Merchant NB
(2014) Cancer Res 74: 2062-72
MeSH Terms: ADAM Proteins, ADAM17 Protein, Amphiregulin, Bile Acids and Salts, Cyclin D1, Deoxycholic Acid, EGF Family of Proteins, ErbB Receptors, Gastrointestinal Neoplasms, Glycoproteins, HCT116 Cells, Humans, Intercellular Signaling Peptides and Proteins, Pancreas, Phosphorylation, Receptors, G-Protein-Coupled, STAT3 Transcription Factor, Transforming Growth Factor alpha, src-Family Kinases
Added February 14, 2014
0 Communities
3 Members
0 Resources
19 MeSH Terms
Myofibroblast keratinocyte growth factor reduces tight junctional integrity and increases claudin-2 levels in polarized Caco-2 cells.
Kim TI, Poulin EJ, Blask E, Bukhalid R, Whitehead RH, Franklin JL, Coffey RJ
(2012) Growth Factors 30: 320-32
MeSH Terms: Amphiregulin, Caco-2 Cells, Cell Communication, Cell Line, Tumor, Cell Membrane Permeability, Cell Proliferation, Claudin-2, Culture Media, Conditioned, EGF Family of Proteins, Electric Impedance, ErbB Receptors, Fibroblast Growth Factor 7, Glycoproteins, Humans, Intercellular Signaling Peptides and Proteins, Intestinal Mucosa, Ligands, Myofibroblasts, Tight Junctions
Added December 5, 2013
2 Communities
2 Members
0 Resources
19 MeSH Terms
Identification of a novel mono-leucine basolateral sorting motif within the cytoplasmic domain of amphiregulin.
Gephart JD, Singh B, Higginbotham JN, Franklin JL, Gonzalez A, Fölsch H, Coffey RJ
(2011) Traffic 12: 1793-804
MeSH Terms: Amino Acid Motifs, Amino Acid Sequence, Amphiregulin, Animals, Cell Line, Cell Membrane, Cell Polarity, Cytoplasm, Dogs, EGF Family of Proteins, Epithelial Cells, ErbB Receptors, Glycoproteins, Humans, Intercellular Signaling Peptides and Proteins, LLC-PK1 Cells, Leucine, Membrane Proteins, Molecular Sequence Data, Protein Structure, Tertiary, Protein Transport, Receptors, Nerve Growth Factor, Swine
Added December 5, 2013
2 Communities
3 Members
0 Resources
23 MeSH Terms
Sustained activation of the HER1-ERK1/2-RSK signaling pathway controls myoepithelial cell fate in human mammary tissue.
Pasic L, Eisinger-Mathason TS, Velayudhan BT, Moskaluk CA, Brenin DR, Macara IG, Lannigan DA
(2011) Genes Dev 25: 1641-53
MeSH Terms: Amphiregulin, Animals, Apoptosis, Bacterial Capsules, Cell Differentiation, Cell Proliferation, Cells, Cultured, EGF Family of Proteins, Epidermal Growth Factor, Epithelial Cells, ErbB Receptors, Glycoproteins, Humans, Intercellular Signaling Peptides and Proteins, Mammary Glands, Human, Mice, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Receptor, Fibroblast Growth Factor, Type 2, Ribosomal Protein S6 Kinases, 90-kDa, Signal Transduction
Added March 5, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Amphiregulin exosomes increase cancer cell invasion.
Higginbotham JN, Demory Beckler M, Gephart JD, Franklin JL, Bogatcheva G, Kremers GJ, Piston DW, Ayers GD, McConnell RE, Tyska MJ, Coffey RJ
(2011) Curr Biol 21: 779-86
MeSH Terms: Amphiregulin, Animals, Cell Line, Tumor, Centrifugation, Dogs, EGF Family of Proteins, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, ErbB Receptors, Exosomes, Glycoproteins, Heparin-binding EGF-like Growth Factor, Humans, Immunoblotting, Intercellular Signaling Peptides and Proteins, Microscopy, Electron, Neoplasm Invasiveness, Signal Transduction, Transforming Growth Factor alpha
Added December 6, 2012
2 Communities
5 Members
0 Resources
19 MeSH Terms
Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer.
Regales L, Gong Y, Shen R, de Stanchina E, Vivanco I, Goel A, Koutcher JA, Spassova M, Ouerfelli O, Mellinghoff IK, Zakowski MF, Politi KA, Pao W
(2009) J Clin Invest 119: 3000-10
MeSH Terms: Afatinib, Amphiregulin, Animals, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Cetuximab, Disease Models, Animal, Drug Resistance, Neoplasm, EGF Family of Proteins, Epidermal Growth Factor, Epiregulin, ErbB Receptors, Erlotinib Hydrochloride, Gene Expression Profiling, Glycoproteins, Humans, Intercellular Signaling Peptides and Proteins, Lung Neoplasms, Male, Mice, Mice, Nude, Mice, Transgenic, Mutation, Neoplasm Transplantation, Paclitaxel, Protein Kinase Inhibitors, Quinazolines, Transplantation, Heterologous, Tumor Cells, Cultured
Added March 24, 2014
0 Communities
1 Members
0 Resources
30 MeSH Terms
Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia.
Nam KT, Lee HJ, Mok H, Romero-Gallo J, Crowe JE, Peek RM, Goldenring JR
(2009) Gastroenterology 136: 1288-96
MeSH Terms: Amphiregulin, Animals, Cell Proliferation, Disease Models, Animal, EGF Family of Proteins, Gastric Fundus, Gastric Mucosa, Genetic Predisposition to Disease, Glycoproteins, Intercellular Signaling Peptides and Proteins, Intestinal Mucosa, Intestines, Metaplasia, Mice, Mice, Inbred C57BL, Mice, Knockout, Mucin-2, Mucins, Muscle Proteins, Peptides, Stomach, Stomach Neoplasms, Transforming Growth Factor alpha, Trefoil Factor-2, Trefoil Factor-3, beta Catenin
Added October 7, 2013
1 Communities
3 Members
0 Resources
26 MeSH Terms