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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 9 of 9

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Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.
Schulte ML, Fu A, Zhao P, Li J, Geng L, Smith ST, Kondo J, Coffey RJ, Johnson MO, Rathmell JC, Sharick JT, Skala MC, Smith JA, Berlin J, Washington MK, Nickels ML, Manning HC
(2018) Nat Med 24: 194-202
MeSH Terms: Amino Acid Transport System ASC, Animals, Cell Line, Tumor, Cell Proliferation, Computer Simulation, Disease Models, Animal, Glutamine, HCT116 Cells, Humans, Mice, Minor Histocompatibility Antigens, Neoplasms, Oxidative Stress, Signal Transduction, Small Molecule Libraries
Added March 14, 2018
0 Communities
4 Members
0 Resources
15 MeSH Terms
The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ.
Edwards DN, Ngwa VM, Wang S, Shiuan E, Brantley-Sieders DM, Kim LC, Reynolds AB, Chen J
(2017) Sci Signal 10:
MeSH Terms: Adaptor Proteins, Signal Transducing, Amino Acid Transport System ASC, Animals, Biomarkers, Tumor, Breast Neoplasms, DNA-Binding Proteins, Disease Models, Animal, Ephrin-A2, Female, Glutaminase, Glutamine, Humans, Intracellular Signaling Peptides and Proteins, Mice, Mice, Knockout, Minor Histocompatibility Antigens, Muscle Proteins, Phosphoproteins, Trans-Activators, Transcription Factors, Tumor Cells, Cultured
Added April 2, 2019
0 Communities
1 Members
0 Resources
21 MeSH Terms
Non-Invasive Glutamine PET Reflects Pharmacological Inhibition of BRAF In Vivo.
Schulte ML, Hight MR, Ayers GD, Liu Q, Shyr Y, Washington MK, Manning HC
(2017) Mol Imaging Biol 19: 421-428
MeSH Terms: Amino Acid Transport System ASC, Animals, Cell Line, Tumor, Colonic Neoplasms, Female, Glutamine, Humans, Liver Neoplasms, Mice, Nude, Minor Histocompatibility Antigens, Mutation, Positron-Emission Tomography, Protein Kinase Inhibitors, Proto-Oncogene Proteins B-raf, Xenograft Model Antitumor Assays
Added April 6, 2017
0 Communities
2 Members
0 Resources
15 MeSH Terms
2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport.
Schulte ML, Khodadadi AB, Cuthbertson ML, Smith JA, Manning HC
(2016) Bioorg Med Chem Lett 26: 1044-1047
MeSH Terms: Amino Acid Transport System ASC, Animals, Binding Sites, Butyrates, Cell Line, Glutamine, HEK293 Cells, Humans, Minor Histocompatibility Antigens, Molecular Docking Simulation, Protein Structure, Tertiary, Rats, Structure-Activity Relationship
Added February 11, 2016
0 Communities
2 Members
0 Resources
13 MeSH Terms
Preclinical Evaluation of 4-[18F]Fluoroglutamine PET to Assess ASCT2 Expression in Lung Cancer.
Hassanein M, Hight MR, Buck JR, Tantawy MN, Nickels ML, Hoeksema MD, Harris BK, Boyd K, Massion PP, Manning HC
(2016) Mol Imaging Biol 18: 18-23
MeSH Terms: Amino Acid Transport System ASC, Animals, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Colonic Neoplasms, ErbB Receptors, Female, Glutamine, Humans, Lung Neoplasms, Male, Mice, Nude, Minor Histocompatibility Antigens, Mutation, Positron-Emission Tomography, Xenograft Model Antitumor Assays
Added September 30, 2015
0 Communities
3 Members
0 Resources
16 MeSH Terms
Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer.
Hassanein M, Qian J, Hoeksema MD, Wang J, Jacobovitz M, Ji X, Harris FT, Harris BK, Boyd KL, Chen H, Eisenberg R, Massion PP
(2015) Int J Cancer 137: 1587-97
MeSH Terms: Amino Acid Transport System ASC, Animals, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Gene Knockdown Techniques, Glutamine, Humans, Lung Neoplasms, Mice, Minor Histocompatibility Antigens, Molecular Targeted Therapy, Prognosis, RNA, Small Interfering, Xenograft Model Antitumor Assays
Added February 16, 2016
0 Communities
1 Members
0 Resources
14 MeSH Terms
2-Substituted Nγ-glutamylanilides as novel probes of ASCT2 with improved potency.
Schulte ML, Dawson ES, Saleh SA, Cuthbertson ML, Manning HC
(2015) Bioorg Med Chem Lett 25: 113-6
MeSH Terms: Amino Acid Transport System ASC, Anilides, Dose-Response Relationship, Drug, Humans, Minor Histocompatibility Antigens, Protein Binding, Protein Structure, Secondary, Structure-Activity Relationship
Added February 12, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms
SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival.
Hassanein M, Hoeksema MD, Shiota M, Qian J, Harris BK, Chen H, Clark JE, Alborn WE, Eisenberg R, Massion PP
(2013) Clin Cancer Res 19: 560-70
MeSH Terms: Adult, Aged, Amino Acid Transport System ASC, Biological Transport, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Cell Line, Tumor, Cell Membrane, Cell Proliferation, Cell Survival, Female, G1 Phase Cell Cycle Checkpoints, Gene Expression, Glutamine, Humans, Lung Neoplasms, Male, Middle Aged, Minor Histocompatibility Antigens, RNA Interference, Reactive Oxygen Species, Sex Factors, Signal Transduction, TOR Serine-Threonine Kinases
Added March 5, 2014
0 Communities
5 Members
0 Resources
24 MeSH Terms
Portal glucose delivery stimulates muscle but not liver protein metabolism.
Kraft G, Coate KC, Dardevet D, Farmer B, Donahue EP, Williams PE, Cherrington AD, Moore MC
(2012) Am J Physiol Endocrinol Metab 303: E1202-11
MeSH Terms: Amino Acid Transport System ASC, Amino Acids, Animals, Dogs, Enteral Nutrition, Glucose, Infusions, Intravenous, Large Neutral Amino Acid-Transporter 1, Liver, Male, Muscle, Skeletal, Phosphorylation, Portal Vein, Postprandial Period, Protein Biosynthesis, Ribosomal Protein S6 Kinases, 70-kDa
Added December 5, 2013
1 Communities
3 Members
1 Resources
16 MeSH Terms