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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 36

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Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors.
Bedse G, Bluett RJ, Patrick TA, Romness NK, Gaulden AD, Kingsley PJ, Plath N, Marnett LJ, Patel S
(2018) Transl Psychiatry 8: 92
MeSH Terms: Amidohydrolases, Animals, Anti-Anxiety Agents, Anxiety Disorders, Behavior, Animal, Benzodioxoles, Body Temperature, Brain, Carbamates, Endocannabinoids, Female, Locomotion, Male, Maze Learning, Mice, Inbred C57BL, Mice, Inbred ICR, Monoacylglycerol Lipases, Piperazines, Piperidines, Pyridines, Stress, Psychological
Added April 12, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
Jiang X, O'Reilly PF, Aschard H, Hsu YH, Richards JB, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, Kestenbaum B, Zheng J, Luan J, Sofianopoulou E, Streeten EA, Albanes D, Lutsey PL, Yao L, Tang W, Econs MJ, Wallaschofski H, Völzke H, Zhou A, Power C, McCarthy MI, Michos ED, Boerwinkle E, Weinstein SJ, Freedman ND, Huang WY, Van Schoor NM, van der Velde N, Groot LCPGM, Enneman A, Cupples LA, Booth SL, Vasan RS, Liu CT, Zhou Y, Ripatti S, Ohlsson C, Vandenput L, Lorentzon M, Eriksson JG, Shea MK, Houston DK, Kritchevsky SB, Liu Y, Lohman KK, Ferrucci L, Peacock M, Gieger C, Beekman M, Slagboom E, Deelen J, Heemst DV, Kleber ME, März W, de Boer IH, Wood AC, Rotter JI, Rich SS, Robinson-Cohen C, den Heijer M, Jarvelin MR, Cavadino A, Joshi PK, Wilson JF, Hayward C, Lind L, Michaëlsson K, Trompet S, Zillikens MC, Uitterlinden AG, Rivadeneira F, Broer L, Zgaga L, Campbell H, Theodoratou E, Farrington SM, Timofeeva M, Dunlop MG, Valdes AM, Tikkanen E, Lehtimäki T, Lyytikäinen LP, Kähönen M, Raitakari OT, Mikkilä V, Ikram MA, Sattar N, Jukema JW, Wareham NJ, Langenberg C, Forouhi NG, Gundersen TE, Khaw KT, Butterworth AS, Danesh J, Spector T, Wang TJ, Hyppönen E, Kraft P, Kiel DP
(2018) Nat Commun 9: 260
MeSH Terms: Amidohydrolases, Autoimmune Diseases, Cohort Studies, Female, Genome-Wide Association Study, Humans, Male, Polymorphism, Single Nucleotide, Vesicular Transport Proteins, Vitamin D, Whites
Added January 3, 2019
0 Communities
1 Members
0 Resources
11 MeSH Terms
Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site.
Goodman MC, Xu S, Rouzer CA, Banerjee S, Ghebreselasie K, Migliore M, Piomelli D, Marnett LJ
(2018) J Biol Chem 293: 3028-3038
MeSH Terms: Amidohydrolases, Catalytic Domain, Cyclooxygenase Inhibitors, Isoenzymes, Phenylcarbamates, Phenylpropionates, Prostaglandin-Endoperoxide Synthases, Protein Binding, Stereoisomerism, Substrate Specificity
Added April 22, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.
Anderson KA, Huynh FK, Fisher-Wellman K, Stuart JD, Peterson BS, Douros JD, Wagner GR, Thompson JW, Madsen AS, Green MF, Sivley RM, Ilkayeva OR, Stevens RD, Backos DS, Capra JA, Olsen CA, Campbell JE, Muoio DM, Grimsrud PA, Hirschey MD
(2017) Cell Metab 25: 838-855.e15
MeSH Terms: Amidohydrolases, Amino Acid Sequence, Animals, Carbon-Carbon Ligases, Glucose, HEK293 Cells, Homeostasis, Humans, Insulin, Insulin Resistance, Insulin Secretion, Leucine, Lysine, Metabolic Flux Analysis, Mice, Inbred C57BL, Mice, Knockout, Mitochondrial Proteins, Models, Molecular, Phylogeny, Sirtuins
Added April 18, 2017
0 Communities
1 Members
0 Resources
20 MeSH Terms
Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling.
Doenni VM, Gray JM, Song CM, Patel S, Hill MN, Pittman QJ
(2016) Brain Behav Immun 58: 237-247
MeSH Terms: Amidohydrolases, Amygdala, Animals, Arachidonic Acids, Behavior, Animal, Endocannabinoids, Female, Glycerides, Inflammation, Lipopolysaccharides, Male, Polyunsaturated Alkamides, Pyridazines, Rats, Sprague-Dawley, Receptor, Cannabinoid, CB1, Signal Transduction, Social Behavior, Urea
Added March 14, 2018
0 Communities
1 Members
0 Resources
18 MeSH Terms
Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids.
Gunduz-Cinar O, Flynn S, Brockway E, Kaugars K, Baldi R, Ramikie TS, Cinar R, Kunos G, Patel S, Holmes A
(2016) Neuropsychopharmacology 41: 1598-609
MeSH Terms: Amidohydrolases, Amygdala, Animals, Anti-Anxiety Agents, Arachidonic Acids, Endocannabinoids, Extinction, Psychological, Fear, Fluoxetine, Male, Mice, Mice, Inbred Strains, Polyunsaturated Alkamides
Added March 14, 2018
0 Communities
1 Members
0 Resources
13 MeSH Terms
Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety.
Gray JM, Vecchiarelli HA, Morena M, Lee TT, Hermanson DJ, Kim AB, McLaughlin RJ, Hassan KI, Kühne C, Wotjak CT, Deussing JM, Patel S, Hill MN
(2015) J Neurosci 35: 3879-92
MeSH Terms: Adrenocorticotropic Hormone, Amidohydrolases, Amygdala, Animals, Anxiety, Arachidonic Acids, Corticotropin-Releasing Hormone, Endocannabinoids, Hydrolysis, Male, Mice, Mice, Knockout, Polyunsaturated Alkamides, Rats, Rats, Sprague-Dawley, Receptors, Corticotropin-Releasing Hormone, Stress, Psychological
Added March 14, 2018
0 Communities
1 Members
0 Resources
17 MeSH Terms
Modification of Helicobacter pylori Peptidoglycan Enhances NOD1 Activation and Promotes Cancer of the Stomach.
Suarez G, Romero-Gallo J, Piazuelo MB, Wang G, Maier RJ, Forsberg LS, Azadi P, Gomez MA, Correa P, Peek RM
(2015) Cancer Res 75: 1749-59
MeSH Terms: Acetylation, Acetyltransferases, Adenocarcinoma, Aged, Amidohydrolases, Animals, Bacterial Proteins, Cell Transformation, Neoplastic, Cells, Cultured, Female, Gastritis, Gene Silencing, Gerbillinae, HEK293 Cells, Helicobacter pylori, Host-Pathogen Interactions, Humans, Male, Middle Aged, Nod1 Signaling Adaptor Protein, Organisms, Genetically Modified, Peptidoglycan, Stomach Neoplasms
Added February 5, 2016
0 Communities
1 Members
0 Resources
23 MeSH Terms
Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation.
Bluett RJ, Gamble-George JC, Hermanson DJ, Hartley ND, Marnett LJ, Patel S
(2014) Transl Psychiatry 4: e408
MeSH Terms: Amidohydrolases, Animals, Anxiety, Arachidonic Acids, Behavior, Animal, Disease Models, Animal, Endocannabinoids, Male, Mice, Mice, Inbred ICR, Polyunsaturated Alkamides, Stress, Psychological
Added January 20, 2015
0 Communities
2 Members
0 Resources
12 MeSH Terms
The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury.
Tchantchou F, Tucker LB, Fu AH, Bluett RJ, McCabe JT, Patel S, Zhang Y
(2014) Neuropharmacology 85: 427-39
MeSH Terms: Amidohydrolases, Animals, Anxiety, Brain, Brain Injuries, Caspase 3, Disease Models, Animal, Extracellular Signal-Regulated MAP Kinases, Male, Memory Disorders, Mice, Inbred C57BL, Motor Activity, Neuroimmunomodulation, Neuroprotective Agents, Piperidines, Proto-Oncogene Proteins c-akt, Pyridines, Receptor, Cannabinoid, CB1, Receptor, Cannabinoid, CB2, Recovery of Function
Added January 20, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms