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Genetically regulated expression in late-onset Alzheimer's disease implicates risk genes within known and novel loci.
Chen HH, Petty LE, Sha J, Zhao Y, Kuzma A, Valladares O, Alzheimer’s Disease Genetics Consortium, International Genomics of Alzheimer’s Project, Bush W, Naj AC, Gamazon ER, Below JE
(2021) Transl Psychiatry 11: 618
MeSH Terms: Alzheimer Disease, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Multifactorial Inheritance, Polymorphism, Single Nucleotide
Added February 15, 2022
0 Communities
1 Members
0 Resources
MeSH Terms
A transcriptome-wide association study of Alzheimer's disease using prediction models of relevant tissues identifies novel candidate susceptibility genes.
Sun Y, Zhu J, Zhou D, Canchi S, Wu C, Cox NJ, Rissman RA, Gamazon ER, Wu L
(2021) Genome Med 13: 141
MeSH Terms: Alleles, Alzheimer Disease, Chromosome Mapping, Computational Biology, Databases, Genetic, Gene Expression Profiling, Gene Expression Regulation, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Models, Biological, Organ Specificity, Polymorphism, Single Nucleotide, Prognosis, Resorcinols, Signal Transduction, Transcriptome
Added October 8, 2021
0 Communities
1 Members
0 Resources
17 MeSH Terms
A transcriptome-wide association study identifies novel blood-based gene biomarker candidates for Alzheimer's disease risk.
Sun Y, Zhou D, Rahman MR, Zhu J, Ghoneim D, Cox NJ, Beach TG, Wu C, Gamazon ER, Wu L
(2021) Hum Mol Genet 31: 289-299
MeSH Terms: Alzheimer Disease, Genetic Markers, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, Quality of Life, Transcriptome
Added October 8, 2021
0 Communities
1 Members
0 Resources
7 MeSH Terms
Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer's disease and myocardial infarction.
Palmer ND, Kahali B, Kuppa A, Chen Y, Du X, Feitosa MF, Bielak LF, O'Connell JR, Musani SK, Guo X, Smith AV, Ryan KA, Eirksdottir G, Allison MA, Bowden DW, Budoff MJ, Carr JJ, Chen YI, Taylor KD, Correa A, Crudup BF, Halligan B, Yang J, Kardia SLR, Launer LJ, Fu YP, Mosley TH, Norris JM, Terry JG, O'Donnell CJ, Rotter JI, Wagenknecht LE, Gudnason V, Province MA, Peyser PA, Speliotes EK
(2021) Hum Mol Genet 30: 1443-1456
MeSH Terms: Alanine Transaminase, Alleles, Alzheimer Disease, Apolipoproteins E, Databases, Genetic, Exome, Gene Frequency, Genome-Wide Association Study, Humans, Liver, Liver Cirrhosis, Myocardial Infarction, Non-alcoholic Fatty Liver Disease, Obesity, Phenotype, Polymorphism, Single Nucleotide, Prognosis, Risk Factors, Triglycerides
Added June 9, 2021
0 Communities
1 Members
0 Resources
19 MeSH Terms
Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease.
Bersini S, Arrojo E Drigo R, Huang L, Shokhirev MN, Hetzer MW
(2020) Adv Biosyst 4: e2000044
MeSH Terms: Aged, Aging, Alzheimer Disease, Endothelial Cells, Female, Fibroblasts, Humans, Male, Microfluidic Analytical Techniques, Microvessels
Added April 14, 2021
0 Communities
1 Members
0 Resources
10 MeSH Terms
An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer's disease.
Gerring ZF, Lupton MK, Edey D, Gamazon ER, Derks EM
(2020) Alzheimers Res Ther 12: 43
MeSH Terms: Alzheimer Disease, Gene Expression, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, Quantitative Trait Loci
Added April 18, 2020
0 Communities
1 Members
0 Resources
6 MeSH Terms
Lower Left Ventricular Ejection Fraction Relates to Cerebrospinal Fluid Biomarker Evidence of Neurodegeneration in Older Adults.
Kresge HA, Liu D, Gupta DK, Moore EE, Osborn KE, Acosta LMY, Bell SP, Pechman KR, Gifford KA, Mendes LA, Wang TJ, Blennow K, Zetterberg H, Hohman TJ, Jefferson AL
(2020) J Alzheimers Dis 74: 965-974
MeSH Terms: Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Biomarkers, Cognition Disorders, Cognitive Dysfunction, Echocardiography, Female, Humans, Male, Mental Status and Dementia Tests, Middle Aged, Neurodegenerative Diseases, Peptide Fragments, Risk Factors, Stroke Volume, Ventricular Function, Left, tau Proteins
Added March 30, 2020
0 Communities
1 Members
0 Resources
19 MeSH Terms
Sex differences in the genetic predictors of Alzheimer's pathology.
Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Bush WS, Gifford KA, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Deming Y, Chao MJ, Huentelman M, Martin ER, Hamilton-Nelson K, Shaw LM, Trojanowski JQ, Peskind ER, Cruchaga C, Pericak-Vance MA, Goate AM, Cox NJ, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Alzheimer’s Disease Genetics Consortium and the Alzheimer’s Disease Neuroimaging Initiative, Bennett DA, Schneider JA, Jefferson AL, Hohman TJ
(2019) Brain 142: 2581-2589
MeSH Terms: Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Cohort Studies, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Polymorphism, Single Nucleotide, Sex Characteristics, tau Proteins
Added March 30, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
Adverse Vascular Risk Relates to Cerebrospinal Fluid Biomarker Evidence of Axonal Injury in the Presence of Alzheimer's Disease Pathology.
Osborn KE, Alverio JM, Dumitrescu L, Pechman KR, Alzheimer’s Disease Neuroimaging Initiative, Gifford KA, Hohman TJ, Blennow K, Zetterberg H, Jefferson AL
(2019) J Alzheimers Dis 71: 281-290
MeSH Terms: Aged, Alzheimer Disease, Axons, Biomarkers, Brain, Cerebrovascular Circulation, Cognitive Dysfunction, Correlation of Data, Female, Humans, Male, Neurofilament Proteins, Neuroimaging, Neuropsychological Tests, Risk Assessment, tau Proteins
Added March 6, 2020
0 Communities
2 Members
0 Resources
16 MeSH Terms
Atypical Clinical Manifestations of Cerebral Amyloid Angiopathy.
Akers C, Acosta LMY, Considine C, Claassen D, Kirshner H, Schrag M
(2019) Curr Neurol Neurosci Rep 19: 64
MeSH Terms: Aged, Alzheimer Disease, Brain, Cerebral Amyloid Angiopathy, Cerebral Hemorrhage, Cognitive Dysfunction, Diagnosis, Differential, Female, Humans, Lewy Body Disease, Male, Neuroimaging
Added March 3, 2020
0 Communities
1 Members
0 Resources
12 MeSH Terms