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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 14

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Mechlorethamine-induced DNA-protein cross-linking in human fibrosarcoma (HT1080) cells.
Michaelson-Richie ED, Ming X, Codreanu SG, Loeber RL, Liebler DC, Campbell C, Tretyakova NY
(2011) J Proteome Res 10: 2785-96
MeSH Terms: Alkylating Agents, Cell Line, Tumor, Cell Survival, Chromatography, High Pressure Liquid, Cross-Linking Reagents, DNA, Neoplasm, DNA-Binding Proteins, Fibrosarcoma, Humans, Mechlorethamine, Peptide Fragments, Proteomics, Tandem Mass Spectrometry
Added March 20, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Checkpoint signaling from a single DNA interstrand crosslink.
Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J
(2009) Mol Cell 35: 704-15
MeSH Terms: Alkylating Agents, Animals, Ataxia Telangiectasia Mutated Proteins, Cell Cycle, Cell Cycle Proteins, Cell Proliferation, Checkpoint Kinase 1, DNA, DNA Damage, DNA Helicases, DNA Repair, DNA Replication, DNA-Directed DNA Polymerase, Fanconi Anemia Complementation Group A Protein, Fanconi Anemia Complementation Group D2 Protein, HeLa Cells, Humans, Nucleic Acid Conformation, Protein Kinases, Protein Serine-Threonine Kinases, Recombinant Proteins, Replication Origin, Replication Protein A, Signal Transduction, Time Factors, Transfection, Xenopus Proteins, Xenopus laevis
Added January 7, 2016
0 Communities
1 Members
0 Resources
28 MeSH Terms
Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway.
Halberg RB, Waggoner J, Rasmussen K, White A, Clipson L, Prunuske AJ, Bacher JW, Sullivan R, Washington MK, Pitot HC, Petrini JH, Albertson DG, Dove WF
(2009) Cancer Res 69: 5768-75
MeSH Terms: Adenocarcinoma, Adenoma, Adenomatous Polyposis Coli Protein, Alkylating Agents, Animals, Cell Cycle Proteins, DNA-Binding Proteins, Disease Models, Animal, Disease Progression, Ethylnitrosourea, Feces, Female, Helicobacter Infections, Helicobacter pylori, Humans, Intestinal Neoplasms, Intestines, Male, Mice, Mice, Inbred C57BL, Mice, Inbred Strains, Mutation, Nuclear Proteins, Signal Transduction, Survival Analysis, Time Factors
Added April 12, 2016
0 Communities
1 Members
0 Resources
26 MeSH Terms
Protein targets of reactive electrophiles in human liver microsomes.
Shin NY, Liu Q, Stamer SL, Liebler DC
(2007) Chem Res Toxicol 20: 859-67
MeSH Terms: Acetaminophen, Alkylating Agents, Biotin, Blotting, Western, Calreticulin, Cell Line, Chromatography, High Pressure Liquid, Cross-Linking Reagents, Cysteine, Dose-Response Relationship, Drug, Electrophoresis, Polyacrylamide Gel, Endoplasmic Reticulum, Glutathione Transferase, Humans, Iodoacetamide, Microsomes, Liver, Molecular Structure, Protein Binding, Proteins, Tandem Mass Spectrometry
Added March 20, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
A review of the role of the sequence-dependent electrostatic landscape in DNA alkylation patterns.
Gold B, Marky LM, Stone MP, Williams LD
(2006) Chem Res Toxicol 19: 1402-14
MeSH Terms: Alkylating Agents, Base Sequence, Cations, Crystallography, X-Ray, DNA, Models, Molecular, Molecular Sequence Data, Nucleic Acid Conformation, Static Electricity
Added May 29, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Structure of the 1,4-bis(2'-deoxyadenosin-N6-yl)-2R,3R-butanediol cross-link arising from alkylation of the human N-ras codon 61 by butadiene diepoxide.
Merritt WK, Nechev LV, Scholdberg TA, Dean SM, Kiehna SE, Chang JC, Harris TM, Harris CM, Lloyd RS, Stone MP
(2005) Biochemistry 44: 10081-92
MeSH Terms: Alkylating Agents, Base Pairing, Butadienes, Butylene Glycols, Codon, Cross-Linking Reagents, DNA Adducts, Deoxyadenosines, Epoxy Compounds, Genes, ras, Humans, Mutagens, Nuclear Magnetic Resonance, Biomolecular, Nucleic Acid Heteroduplexes, Oligodeoxyribonucleotides, Protons
Added May 29, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells.
VĂ©lez-Cruz R, Riggins JN, Daniels JS, Cai H, Guengerich FP, Marnett LJ, Osheroff N
(2005) Biochemistry 44: 3972-81
MeSH Terms: Acetaldehyde, Alkylating Agents, Antigens, Neoplasm, Cell Line, Tumor, Cell Survival, DNA Adducts, DNA Damage, DNA Repair, DNA Topoisomerases, Type II, DNA-Binding Proteins, Deoxyguanosine, Histone-Lysine N-Methyltransferase, Humans, Myeloid-Lymphoid Leukemia Protein, Proto-Oncogenes, Transcription Factors
Added March 5, 2014
0 Communities
3 Members
0 Resources
16 MeSH Terms
Structure of an oligodeoxynucleotide containing a butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adduct in the human N-ras codon 61 sequence.
Scholdberg TA, Merritt WK, Dean SM, Kowalcyzk A, Harris CM, Harris TM, Rizzo CJ, Lloyd RS, Stone MP
(2005) Biochemistry 44: 3327-37
MeSH Terms: Alkylating Agents, Base Sequence, Butadienes, Codon, DNA Adducts, Epoxy Compounds, Genes, ras, Humans, Inosine, Magnetic Resonance Spectroscopy, Models, Molecular, Mutagenesis, Site-Directed, Nucleic Acid Conformation, Oligodeoxyribonucleotides, Protons, Thermodynamics
Added May 29, 2014
0 Communities
2 Members
0 Resources
16 MeSH Terms
Global shifts in protein sumoylation in response to electrophile and oxidative stress.
Manza LL, Codreanu SG, Stamer SL, Smith DL, Wells KS, Roberts RL, Liebler DC
(2004) Chem Res Toxicol 17: 1706-15
MeSH Terms: Aldehydes, Alkylating Agents, Amino Acid Sequence, Cell Line, Genetic Vectors, Humans, Hydrogen Peroxide, Molecular Sequence Data, Oxidative Stress, Plasmids, Proteins, SUMO-1 Protein, Signal Transduction, Small Ubiquitin-Related Modifier Proteins
Added March 14, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
S-(2-chloroethyl)glutathione-generated p53 mutation spectra are influenced by differential repair rates more than sites of initial dna damage.
Valadez JG, Guengerich FP
(2004) J Biol Chem 279: 13435-46
MeSH Terms: Alkylating Agents, DNA Adducts, DNA Repair, Genes, Reporter, Glutathione, Mutagenesis, Mutagens, Nucleotides, Saccharomyces cerevisiae, Tumor Suppressor Protein p53
Added March 5, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms