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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 21

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Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease.
Di Pardo A, Amico E, Basit A, Armirotti A, Joshi P, Neely MD, Vuono R, Castaldo S, Digilio AF, Scalabrì F, Pepe G, Elifani F, Madonna M, Jeong SK, Park BM, D'Esposito M, Bowman AB, Barker RA, Maglione V
(2017) Sci Rep 7: 5280
MeSH Terms: Aged, Aldehyde-Lyases, Animals, Disease Models, Animal, Enzyme Inhibitors, Gene Expression Regulation, Humans, Huntington Disease, Lysophospholipids, Male, Mice, Molecular Targeted Therapy, Phosphotransferases (Alcohol Group Acceptor), Receptors, Lysosphingolipid, Sphingosine
Added April 11, 2018
0 Communities
1 Members
0 Resources
15 MeSH Terms
Mechanistic aspects of CYP74 allene oxide synthases and related cytochrome P450 enzymes.
Brash AR
(2009) Phytochemistry 70: 1522-31
MeSH Terms: Aldehyde-Lyases, Cytochrome P-450 Enzyme System, Intramolecular Oxidoreductases, Models, Biological, Plant Proteins, Plants, Thromboxane-A Synthase
Added December 10, 2013
0 Communities
1 Members
0 Resources
7 MeSH Terms
Biogenesis of volatile aldehydes from fatty acid hydroperoxides: molecular cloning of a hydroperoxide lyase (CYP74C) with specificity for both the 9- and 13-hydroperoxides of linoleic and linolenic acids.
Tijet N, Schneider C, Muller BL, Brash AR
(2001) Arch Biochem Biophys 386: 281-9
MeSH Terms: Aldehyde-Lyases, Aldehydes, Amino Acid Sequence, Base Sequence, Catalysis, Chromatography, High Pressure Liquid, Cloning, Molecular, Cucurbitaceae, Cytochrome P-450 Enzyme System, Escherichia coli, Gas Chromatography-Mass Spectrometry, Hydrogen-Ion Concentration, Kinetics, Linoleic Acid, Lipid Peroxides, Molecular Sequence Data, Phylogeny, Recombinant Fusion Proteins, Spectrum Analysis, Substrate Specificity, alpha-Linolenic Acid
Added December 10, 2013
0 Communities
2 Members
0 Resources
21 MeSH Terms
Two distinct pathways of formation of 4-hydroxynonenal. Mechanisms of nonenzymatic transformation of the 9- and 13-hydroperoxides of linoleic acid to 4-hydroxyalkenals.
Schneider C, Tallman KA, Porter NA, Brash AR
(2001) J Biol Chem 276: 20831-8
MeSH Terms: Aldehyde-Lyases, Aldehydes, Chromatography, High Pressure Liquid, Cucurbitaceae, Cytochrome P-450 Enzyme System, Kinetics, Linoleic Acids, Lipid Peroxides, Lipoxygenase, Recombinant Proteins, Soybeans, Spectrophotometry, Ultraviolet, Stereoisomerism, Vitamin E
Added December 10, 2013
0 Communities
3 Members
0 Resources
14 MeSH Terms
Purification, molecular cloning, and expression of the gene encoding fatty acid 13-hydroperoxide lyase from guava fruit (Psidium guajava).
Tijet N, Wäspi U, Gaskin DJ, Hunziker P, Muller BL, Vulfson EN, Slusarenko A, Brash AR, Whitehead IM
(2000) Lipids 35: 709-20
MeSH Terms: Aldehyde-Lyases, Amino Acid Sequence, Base Sequence, Chromatography, Gel, Cloning, Molecular, Cytochrome P-450 Enzyme System, Enzyme Stability, Fruit, Genes, Plant, Kinetics, Molecular Sequence Data, Plants, Polymerase Chain Reaction, Recombinant Proteins, Sequence Alignment, Sequence Homology, Amino Acid, Vegetables
Added December 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
cAMP-dependent and tissue-specific expression of genes encoding steroidogenic enzymes in bovine luteal and granulosa cells in primary culture.
Lauber ME, Kagawa N, Waterman MR, Simpson ER
(1993) Mol Cell Endocrinol 93: 227-33
MeSH Terms: Adrenodoxin, Aldehyde-Lyases, Animals, Aromatase, Base Sequence, Cattle, Cells, Cultured, Cholesterol Side-Chain Cleavage Enzyme, Colforsin, Corpus Luteum, Cyclic AMP, Cytochrome P-450 Enzyme System, Enzyme Induction, Female, Gonadal Steroid Hormones, Granulosa Cells, Molecular Sequence Data, Organ Specificity, Recombinant Fusion Proteins, Second Messenger Systems, Steroid 17-alpha-Hydroxylase, Steroids, Transfection
Added February 12, 2015
0 Communities
1 Members
0 Resources
23 MeSH Terms
Dexamethasone inhibits corticotropin-induced accumulation of CYP11A and CYP17 messenger RNAs in bovine adrenocortical cells.
Trzeciak WH, LeHoux JG, Waterman MR, Simpson ER
(1993) Mol Endocrinol 7: 206-13
MeSH Terms: Adrenal Cortex, Adrenocorticotropic Hormone, Aldehyde-Lyases, Animals, Cattle, Cells, Cultured, Cholesterol Side-Chain Cleavage Enzyme, Colforsin, Cytochrome P-450 Enzyme System, Dexamethasone, Enzyme Induction, Hydrocortisone, Mifepristone, Promoter Regions, Genetic, RNA, Messenger, Receptors, Glucocorticoid, Recombinant Fusion Proteins, Steroid 17-alpha-Hydroxylase
Added February 12, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Flavodoxin and NADPH-flavodoxin reductase from Escherichia coli support bovine cytochrome P450c17 hydroxylase activities.
Jenkins CM, Waterman MR
(1994) J Biol Chem 269: 27401-8
MeSH Terms: Aldehyde-Lyases, Amino Acid Sequence, Animals, Bacterial Proteins, Cattle, Cytochrome P-450 Enzyme System, Enzyme Activation, Escherichia coli, Ferredoxin-NADP Reductase, Flavodoxin, Molecular Sequence Data, NAD, NADH, NADPH Oxidoreductases, NADPH-Ferrihemoprotein Reductase, Progesterone, Rats, Recombinant Proteins, Sequence Alignment, Sequence Homology, Amino Acid, Spectrum Analysis, Steroid 17-alpha-Hydroxylase
Added February 12, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms
The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.
Katagiri M, Kagawa N, Waterman MR
(1995) Arch Biochem Biophys 317: 343-7
MeSH Terms: 17-alpha-Hydroxypregnenolone, 17-alpha-Hydroxyprogesterone, Aldehyde-Lyases, Androgens, Androstenedione, Cell Membrane, Cytochrome P-450 Enzyme System, Cytochromes b5, Dehydroepiandrosterone, Escherichia coli, Humans, Hydroxyprogesterones, Kinetics, Pregnenolone, Progesterone, Recombinant Proteins, Steroid 17-alpha-Hydroxylase
Added February 12, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Combined 17 alpha-hydroxylase/17,20-lyase deficiency due to a stop codon in the N-terminal region of 17 alpha-hydroxylase cytochrome P-450.
Yanase T, Kagimoto M, Matsui N, Simpson ER, Waterman MR
(1988) Mol Cell Endocrinol 59: 249-53
MeSH Terms: Adrenal Cortex, Adrenal Hyperplasia, Congenital, Adult, Aldehyde-Lyases, Amenorrhea, Amino Acid Sequence, Base Sequence, Blotting, Southern, Codon, Cytochrome P-450 Enzyme System, Exons, Female, Humans, Hypertension, Molecular Sequence Data, Mutation, Osteoporosis, Ovary, RNA, Messenger, Steroid Hydroxylases
Added February 12, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms