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Results: 1 to 10 of 13

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Ibrutinib-Mediated Atrial Fibrillation Attributable to Inhibition of C-Terminal Src Kinase.
Xiao L, Salem JE, Clauss S, Hanley A, Bapat A, Hulsmans M, Iwamoto Y, Wojtkiewicz G, Cetinbas M, Schloss MJ, Tedeschi J, Lebrun-Vignes B, Lundby A, Sadreyev RI, Moslehi J, Nahrendorf M, Ellinor PT, Milan DJ
(2020) Circulation 142: 2443-2455
MeSH Terms: Action Potentials, Adenine, Agammaglobulinaemia Tyrosine Kinase, Animals, Antineoplastic Agents, Atrial Fibrillation, Atrial Function, Left, CSK Tyrosine-Protein Kinase, Databases, Genetic, Heart Atria, Heart Rate, Humans, Mice, 129 Strain, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Knockout, Piperidines, Protein Kinase Inhibitors, Risk Assessment, Risk Factors
Added January 23, 2021
0 Communities
1 Members
0 Resources
20 MeSH Terms
Bruton's Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages.
Nyhoff LE, Clark ES, Barron BL, Bonami RH, Khan WN, Kendall PL
(2018) J Immunol 200: 2352-2361
MeSH Terms: Agammaglobulinaemia Tyrosine Kinase, Animals, Autoimmune Diseases, B-Lymphocyte Subsets, Cell Survival, Cells, Cultured, Immunoglobulin M, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, Antigen, B-Cell, Signal Transduction
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Myc enhances B-cell receptor signaling in precancerous B cells and confers resistance to Btk inhibition.
Moyo TK, Wilson CS, Moore DJ, Eischen CM
(2017) Oncogene 36: 4653-4661
MeSH Terms: Adenine, Agammaglobulinaemia Tyrosine Kinase, Animals, B-Lymphocytes, CD79 Antigens, Cell Proliferation, Flow Cytometry, Humans, Lymphoma, Non-Hodgkin, Male, Mice, Mice, Inbred C57BL, Mitogen-Activated Protein Kinase 3, Phosphatidylinositol 3-Kinases, Phospholipase C gamma, Phosphorylation, Piperidines, Precancerous Conditions, Protein-Tyrosine Kinases, Proto-Oncogene Proteins c-myc, Pyrazoles, Pyrimidines, Receptors, Antigen, B-Cell, Splenic Neoplasms, Syk Kinase
Added April 6, 2017
0 Communities
1 Members
0 Resources
25 MeSH Terms
Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling.
Myklebust JH, Brody J, Kohrt HE, Kolstad A, Czerwinski DK, Wälchli S, Green MR, Trøen G, Liestøl K, Beiske K, Houot R, Delabie J, Alizadeh AA, Irish JM, Levy R
(2017) Blood 129: 759-770
MeSH Terms: Agammaglobulinaemia Tyrosine Kinase, CD79 Antigens, Diagnosis, Differential, Flow Cytometry, Gene Expression Regulation, Neoplastic, Humans, Immunoglobulin M, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Follicular, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Phospholipase C gamma, Phosphoproteins, Phosphorylation, Protein-Tyrosine Kinases, Proto-Oncogene Proteins c-akt, Receptors, Antigen, B-Cell, STAT1 Transcription Factor, STAT5 Transcription Factor, Signal Transduction, Single-Cell Analysis, Syk Kinase, p38 Mitogen-Activated Protein Kinases, src-Family Kinases
Added December 31, 2016
1 Communities
1 Members
0 Resources
26 MeSH Terms
Reply.
Nyhoff LE, Crofford LJ, Kendall PL
(2017) Arthritis Rheumatol 69: 475-477
MeSH Terms: Agammaglobulinaemia Tyrosine Kinase, Arthritis, Rheumatoid, Humans
Added July 18, 2017
1 Communities
1 Members
0 Resources
3 MeSH Terms
Bruton's Tyrosine Kinase Deficiency Inhibits Autoimmune Arthritis in Mice but Fails to Block Immune Complex-Mediated Inflammatory Arthritis.
Nyhoff LE, Barron BL, Johnson EM, Bonami RH, Maseda D, Fensterheim BA, Han W, Blackwell TS, Crofford LJ, Kendall PL
(2016) Arthritis Rheumatol 68: 1856-68
MeSH Terms: Agammaglobulinaemia Tyrosine Kinase, Animals, Antigen-Antibody Complex, Arthritis, Autoimmune Diseases, Male, Mice, Protein-Tyrosine Kinases
Added October 12, 2016
1 Communities
4 Members
0 Resources
8 MeSH Terms
The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy.
Crofford LJ, Nyhoff LE, Sheehan JH, Kendall PL
(2016) Expert Rev Clin Immunol 12: 763-73
MeSH Terms: Agammaglobulinaemia Tyrosine Kinase, Animals, Anti-Inflammatory Agents, Autoantibodies, Autoimmune Diseases, Autoimmunity, B-Lymphocytes, Humans, Immune Tolerance, Lymphocyte Activation, Protein-Tyrosine Kinases, Receptors, Antigen, B-Cell, Signal Transduction
Added July 18, 2017
1 Communities
2 Members
0 Resources
13 MeSH Terms
Bruton's Tyrosine Kinase Synergizes with Notch2 To Govern Marginal Zone B Cells in Nonobese Diabetic Mice.
Case JB, Bonami RH, Nyhoff LE, Steinberg HE, Sullivan AM, Kendall PL
(2015) J Immunol 195: 61-70
MeSH Terms: Agammaglobulinaemia Tyrosine Kinase, Animals, Autoantibodies, Autoimmunity, B-Lymphocyte Subsets, Cell Differentiation, Cell Survival, Diabetes Mellitus, Experimental, Female, Gene Expression Regulation, Immunoglobulin Heavy Chains, Insulin, Male, Mice, Mice, Inbred C57BL, Mice, Inbred NOD, Protein-Tyrosine Kinases, Receptor, Notch2, Receptors, Antigen, B-Cell, Signal Transduction
Added December 4, 2015
2 Communities
1 Members
0 Resources
20 MeSH Terms
Bruton's tyrosine kinase promotes persistence of mature anti-insulin B cells.
Bonami RH, Sullivan AM, Case JB, Steinberg HE, Hoek KL, Khan WN, Kendall PL
(2014) J Immunol 192: 1459-70
MeSH Terms: Agammaglobulinaemia Tyrosine Kinase, Animals, B-Lymphocytes, Cells, Cultured, Diabetes Mellitus, Type 1, Immunoglobulins, Insulin, Insulin Antibodies, Mice, Mice, Inbred C57BL, Mice, Inbred NOD, Mice, Transgenic, Protein-Tyrosine Kinases, Receptors, Antigen, B-Cell
Added May 19, 2014
1 Communities
2 Members
0 Resources
14 MeSH Terms
Reduced diabetes in btk-deficient nonobese diabetic mice and restoration of diabetes with provision of an anti-insulin IgH chain transgene.
Kendall PL, Moore DJ, Hulbert C, Hoek KL, Khan WN, Thomas JW
(2009) J Immunol 183: 6403-12
MeSH Terms: Agammaglobulinaemia Tyrosine Kinase, Animals, Autoantibodies, B-Lymphocyte Subsets, Diabetes Mellitus, Type 1, Immune Tolerance, Immunoglobulin Heavy Chains, Insulin, Insulin Antibodies, Mice, Mice, Inbred C57BL, Mice, Inbred NOD, Mice, Knockout, Mutation, Protein-Tyrosine Kinases, Receptors, Antigen, B-Cell, Signal Transduction, T-Lymphocyte Subsets, Transgenes
Added December 10, 2013
3 Communities
3 Members
0 Resources
19 MeSH Terms