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Results: 1 to 10 of 15

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Adenovirus E1A coding sequences that enable ras and pmt oncogenes to transform cultured primary cells.
Zerler B, Moran B, Maruyama K, Moomaw J, Grodzicker T, Ruley HE
(1986) Mol Cell Biol 6: 887-99
MeSH Terms: Adenovirus Early Proteins, Adenoviruses, Human, Animals, Base Sequence, Cell Line, Cell Transformation, Neoplastic, DNA, Genes, Genes, Viral, Humans, Kidney, Oncogene Proteins, Viral, Oncogenes, Plasmids, Polyomavirus, Protein Biosynthesis, Rats
Added May 29, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Two regions of the adenovirus early region 1A proteins are required for transformation.
Whyte P, Ruley HE, Harlow E
(1988) J Virol 62: 257-65
MeSH Terms: Adenovirus Early Proteins, Animals, Cell Line, Cell Transformation, Viral, DNA Mutational Analysis, Genes, ras, Oncogene Proteins, Viral, Rats, Structure-Activity Relationship
Added May 29, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Expression of the adenovirus E1A oncogene during cell transformation is sufficient to induce susceptibility to lysis by host inflammatory cells.
Cook JL, Walker TA, Lewis AM, Ruley HE, Graham FL, Pilder SH
(1986) Proc Natl Acad Sci U S A 83: 6965-9
MeSH Terms: Adenovirus Early Proteins, Adenoviruses, Human, Cell Line, Cell Transformation, Neoplastic, Cell Transformation, Viral, Cytotoxicity, Immunologic, Genes, Viral, Killer Cells, Natural, Macrophages, Oncogene Proteins, Viral, Oncogenes, Phenotype, RNA, Messenger
Added May 29, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
myc and E1A oncogenes alter the responses of PC12 cells to nerve growth factor and block differentiation.
Maruyama K, Schiavi SC, Huse W, Johnson GL, Ruley HE
(1987) Oncogene 1: 361-7
MeSH Terms: Adenovirus Early Proteins, Cell Differentiation, Cell Division, DNA Replication, Enzyme Induction, Nerve Growth Factors, Oncogene Proteins, Viral, Oncogenes, Ornithine Decarboxylase, Pheochromocytoma, Receptors, Cell Surface, Receptors, Nerve Growth Factor, Tumor Cells, Cultured
Added May 29, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Role of c-myc in the transformation of REF52 cells by viral and cellular oncogenes.
Kohl NE, Ruley HE
(1987) Oncogene 2: 41-8
MeSH Terms: Adenovirus Early Proteins, Animals, Antigens, Viral, Tumor, Cell Division, Cell Line, Cell Transformation, Neoplastic, Gene Expression Regulation, Oncogene Proteins, Viral, Oncogenes, Proto-Oncogene Proteins, Rats, Simian virus 40, Transcription, Genetic
Added May 29, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Insulin gene enhancer activity is inhibited by adenovirus 5 E1a gene products.
Stein RW, Whelan J
(1989) Mol Cell Biol 9: 4531-4
MeSH Terms: Adenoviridae, Adenovirus Early Proteins, Animals, Chloramphenicol O-Acetyltransferase, DNA Mutational Analysis, Enhancer Elements, Genetic, Gene Expression Regulation, Insulin, Oncogene Proteins, Viral, Plasmids, Rats, Recombinant Fusion Proteins, Repressor Proteins, Transfection
Added December 10, 2013
0 Communities
1 Members
0 Resources
14 MeSH Terms
Adenovirus E1A-mediated negative control of genes activated during F9 differentiation.
Young KS, Weigel R, Hiebert S, Nevins JR
(1989) Mol Cell Biol 9: 3109-13
MeSH Terms: Adenoviridae, Adenovirus Early Proteins, Animals, Cell Differentiation, Collagen, Gene Expression Regulation, Genetic Complementation Test, Oncogene Proteins, Viral, Phenotype, Tissue Plasminogen Activator, Transcription, Genetic, Tumor Cells, Cultured
Added June 10, 2010
1 Communities
1 Members
0 Resources
12 MeSH Terms
E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor.
Hiebert SW, Lipp M, Nevins JR
(1989) Proc Natl Acad Sci U S A 86: 3594-8
MeSH Terms: Adenovirus Early Proteins, Binding Sites, Binding, Competitive, DNA Mutational Analysis, DNA-Binding Proteins, Gene Expression Regulation, HeLa Cells, Methylation, Oncogene Proteins, Viral, Promoter Regions, Genetic, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-myc, Transcription Factors
Added June 10, 2010
1 Communities
1 Members
0 Resources
13 MeSH Terms
Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity.
Stein RW, Corrigan M, Yaciuk P, Whelan J, Moran E
(1990) J Virol 64: 4421-7
MeSH Terms: Adenovirus Early Proteins, Adenoviruses, Human, Animals, Antibodies, Monoclonal, Cell Line, Cell Transformation, Viral, Chromosome Deletion, DNA Replication, DNA, Viral, DNA-Binding Proteins, Enhancer Elements, Genetic, HeLa Cells, Humans, Insulin, Molecular Weight, Mutation, Oncogene Proteins, Viral, RNA, Messenger, Repressor Proteins, Thymidine, Transcription Factors
Added December 10, 2013
0 Communities
1 Members
0 Resources
21 MeSH Terms
A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway.
Mudryj M, Hiebert SW, Nevins JR
(1990) EMBO J 9: 2179-84
MeSH Terms: Adenoviridae, Adenovirus Early Proteins, Animals, Base Sequence, Cell Division, Cells, Cultured, Cloning, Molecular, DNA Replication, DNA-Binding Proteins, Genes, Viral, Kinetics, Mice, Molecular Sequence Data, Oligonucleotide Probes, Oncogene Proteins, Viral, Promoter Regions, Genetic, Restriction Mapping, Sequence Homology, Nucleic Acid, Signal Transduction, Transcription Factors, Transcription, Genetic, Transfection
Added June 10, 2010
1 Communities
1 Members
0 Resources
22 MeSH Terms