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Results: 1 to 10 of 18

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Development of a reliable automated screening system to identify small molecules and biologics that promote human β-cell regeneration.
Aamodt KI, Aramandla R, Brown JJ, Fiaschi-Taesch N, Wang P, Stewart AF, Brissova M, Powers AC
(2016) Am J Physiol Endocrinol Metab 311: E859-E868
MeSH Terms: Activins, Adenosine, Adenosine A2 Receptor Agonists, Adenosine-5'-(N-ethylcarboxamide), Adult, Automation, Cell Culture Techniques, Cell Proliferation, Drug Evaluation, Preclinical, Erythropoietin, Exenatide, Female, GABA Agents, Harmine, Humans, Incretins, Insulin-Secreting Cells, Male, Middle Aged, Monoamine Oxidase Inhibitors, Myostatin, Nucleosides, Peptides, Platelet-Derived Growth Factor, Prolactin, Regeneration, Serotonin, Serotonin Receptor Agonists, Vasodilator Agents, Venoms, Young Adult, gamma-Aminobutyric Acid
Added April 26, 2017
0 Communities
2 Members
0 Resources
32 MeSH Terms
Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptors.
Zhu CB, Steiner JA, Munn JL, Daws LC, Hewlett WA, Blakely RD
(2007) J Pharmacol Exp Ther 322: 332-40
MeSH Terms: Adenosine, Adenosine-5'-(N-ethylcarboxamide), Animals, Biological Transport, Cyclic GMP-Dependent Protein Kinases, MAP Kinase Signaling System, Male, Mice, Mice, Inbred C57BL, Rats, Rats, Sprague-Dawley, Receptor, Adenosine A3, Serotonin, Serotonin Plasma Membrane Transport Proteins, Synaptosomes, p38 Mitogen-Activated Protein Kinases
Added July 10, 2013
1 Communities
1 Members
0 Resources
16 MeSH Terms
Role of adenosine receptors in the regulation of angiogenic factors and neovascularization in hypoxia.
Ryzhov S, McCaleb JL, Goldstein AE, Biaggioni I, Feoktistov I
(2007) J Pharmacol Exp Ther 320: 565-72
MeSH Terms: Adenosine, Adenosine-5'-(N-ethylcarboxamide), Animals, Cells, Cultured, Gene Expression Regulation, Hindlimb, Humans, Hypoxia, Interleukin-8, Ischemia, Male, Mice, Mice, Inbred C57BL, Neovascularization, Physiologic, RNA, Messenger, Receptors, Purinergic P1, Vascular Endothelial Growth Factor A
Added December 10, 2013
0 Communities
2 Members
0 Resources
17 MeSH Terms
Cross-talk between G(s)- and G(q)-coupled pathways in regulation of interleukin-4 by A(2B) adenosine receptors in human mast cells.
Ryzhov S, Goldstein AE, Biaggioni I, Feoktistov I
(2006) Mol Pharmacol 70: 727-35
MeSH Terms: Adenosine-5'-(N-ethylcarboxamide), Cells, Cultured, Colforsin, GTP-Binding Protein alpha Subunits, Gq-G11, GTP-Binding Protein alpha Subunits, Gs, Humans, Interleukin-4, Mast Cells, NFATC Transcription Factors, Receptor, Adenosine A2B, Signal Transduction, Up-Regulation
Added December 10, 2013
0 Communities
2 Members
0 Resources
12 MeSH Terms
Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma.
Ryzhov S, Goldstein AE, Matafonov A, Zeng D, Biaggioni I, Feoktistov I
(2004) J Immunol 172: 7726-33
MeSH Terms: Adenosine, Adenosine-5'-(N-ethylcarboxamide), Asthma, B-Lymphocytes, Cell Communication, Cells, Cultured, Coculture Techniques, Cytokines, Humans, Immunoglobulin E, Interleukin-13, Interleukin-4, Mast Cells, RNA, Messenger, Receptor, Adenosine A2B, Th2 Cells, Up-Regulation
Added December 10, 2013
0 Communities
2 Members
0 Resources
17 MeSH Terms
Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation.
Zhu CB, Hewlett WA, Feoktistov I, Biaggioni I, Blakely RD
(2004) Mol Pharmacol 65: 1462-74
MeSH Terms: Adenosine-5'-(N-ethylcarboxamide), Animals, Biological Transport, CHO Cells, Calcium, Carrier Proteins, Cells, Cultured, Cricetinae, Cyclic GMP, Cyclic GMP-Dependent Protein Kinases, Female, Guanylate Cyclase, Membrane Glycoproteins, Membrane Transport Proteins, Mitogen-Activated Protein Kinases, Nerve Tissue Proteins, Phosphodiesterase Inhibitors, Piperazines, Purines, Rats, Receptors, Purinergic P1, Serotonin, Serotonin Plasma Membrane Transport Proteins, Sildenafil Citrate, Sulfones, Type C Phospholipases, Up-Regulation, p38 Mitogen-Activated Protein Kinases
Added December 10, 2013
1 Communities
3 Members
0 Resources
28 MeSH Terms
Inhibition of human mast cell activation with the novel selective adenosine A(2B) receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)(2).
Feoktistov I, Garland EM, Goldstein AE, Zeng D, Belardinelli L, Wells JN, Biaggioni I
(2001) Biochem Pharmacol 62: 1163-73
MeSH Terms: Adenosine, Adenosine-5'-(N-ethylcarboxamide), Anti-Asthmatic Agents, Cells, Cultured, Humans, Mast Cells, Purinergic P1 Receptor Antagonists, Pyrrolidinones, Receptor, Adenosine A2B, Receptors, Purinergic P1, Structure-Activity Relationship, Vasodilator Agents, Xanthine, Xanthines
Added December 10, 2013
0 Communities
2 Members
0 Resources
14 MeSH Terms
Proliferation, migration, and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation.
Grant MB, Davis MI, Caballero S, Feoktistov I, Biaggioni I, Belardinelli L
(2001) Invest Ophthalmol Vis Sci 42: 2068-73
MeSH Terms: Adenosine-5'-(N-ethylcarboxamide), Blotting, Western, Capillaries, Cell Count, Cell Division, Cell Movement, Cells, Cultured, Cyclic AMP Response Element-Binding Protein, Dose-Response Relationship, Drug, Endothelium, Vascular, Enzyme Activation, Enzyme Inhibitors, Humans, Mitogen-Activated Protein Kinases, Purinergic P1 Receptor Antagonists, Receptor, Adenosine A2B, Receptors, Purinergic P1, Retinal Vessels, Signal Transduction, Vasodilator Agents
Added December 10, 2013
0 Communities
2 Members
0 Resources
20 MeSH Terms
Adenosine A(2A) and A(2B) receptors in cultured human and porcine coronary artery endothelial cells.
Olanrewaju HA, Qin W, Feoktistov I, Scemama JL, Mustafa SJ
(2000) Am J Physiol Heart Circ Physiol 279: H650-6
MeSH Terms: 2-Chloroadenosine, Adenosine, Adenosine-5'-(N-ethylcarboxamide), Affinity Labels, Animals, Binding, Competitive, Cells, Cultured, Coronary Vessels, Cyclic AMP, Endothelium, Vascular, Gene Expression Regulation, Humans, Iodine Radioisotopes, Iodobenzenes, Kinetics, Phenethylamines, Purinergic P1 Receptor Antagonists, Radioligand Assay, Receptor, Adenosine A2A, Receptor, Adenosine A2B, Receptors, Purinergic P1, Reverse Transcriptase Polymerase Chain Reaction, Swine, Transcription, Genetic, Triazines, Triazoles
Added May 29, 2014
0 Communities
1 Members
0 Resources
26 MeSH Terms
A galpha(s) carboxyl-terminal peptide prevents G(s) activation by the A(2A) adenosine receptor.
Mazzoni MR, Taddei S, Giusti L, Rovero P, Galoppini C, D'Ursi A, Albrizio S, Triolo A, Novellino E, Greco G, Lucacchini A, Hamm HE
(2000) Mol Pharmacol 58: 226-36
MeSH Terms: Adenosine, Adenosine-5'-(N-ethylcarboxamide), Animals, Binding, Competitive, Cell Membrane, GTP-Binding Protein alpha Subunits, Gs, In Vitro Techniques, Magnetic Resonance Spectroscopy, Male, Molecular Sequence Data, Peptides, Phenethylamines, Protein Conformation, Pyrimidines, Radioligand Assay, Rats, Rats, Sprague-Dawley, Receptor, Adenosine A2A, Receptors, Purinergic P1, Signal Transduction, Triazoles, Tritium
Added December 10, 2013
0 Communities
1 Members
0 Resources
22 MeSH Terms