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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 6 of 6

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The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.
Jones CK, Bubser M, Thompson AD, Dickerson JW, Turle-Lorenzo N, Amalric M, Blobaum AL, Bridges TM, Morrison RD, Jadhav S, Engers DW, Italiano K, Bode J, Daniels JS, Lindsley CW, Hopkins CR, Conn PJ, Niswender CM
(2012) J Pharmacol Exp Ther 340: 404-21
MeSH Terms: 3,4-Dihydroxyphenylacetic Acid, Adenosine A2 Receptor Antagonists, Animals, Brain, Calcium Signaling, Catalepsy, Corpus Striatum, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Synergism, Drug Therapy, Combination, G Protein-Coupled Inwardly-Rectifying Potassium Channels, Glutamic Acid, HEK293 Cells, Haloperidol, Humans, Levodopa, Male, Monoamine Oxidase, Motor Neuron Disease, Oxidopamine, Parkinson Disease, Picolinic Acids, Protein Binding, Psychomotor Performance, Pyrimidines, Rats, Rats, Sprague-Dawley, Rats, Wistar, Reaction Time, Receptors, G-Protein-Coupled, Receptors, Metabotropic Glutamate, Substantia Nigra, Thallium, Transfection, Triazoles, Tyrosine 3-Monooxygenase
Added February 19, 2015
0 Communities
3 Members
0 Resources
37 MeSH Terms
Adenosine receptors in regulation of dendritic cell differentiation and function.
Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM
(2008) Blood 112: 1822-31
MeSH Terms: Adenosine, Adenosine A2 Receptor Antagonists, Adenosine Deaminase, Animals, Base Sequence, Cell Differentiation, DNA Primers, Dendritic Cells, Humans, Immune Tolerance, Inflammation Mediators, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Neoplasms, Experimental, Neovascularization, Pathologic, Purinergic P1 Receptor Antagonists, Receptor, Adenosine A2B, Receptors, Purinergic P1, Signal Transduction
Added December 10, 2013
0 Communities
3 Members
0 Resources
21 MeSH Terms
Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells.
Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Dikov MM, Blackburn MR, Biaggioni I, Feoktistov I
(2008) J Immunol 180: 7212-20
MeSH Terms: Adenosine, Adenosine A2 Receptor Antagonists, Adenosine Monophosphate, Animals, Bone Marrow Cells, Cell Degranulation, Cell Line, Cells, Cultured, Extracellular Signal-Regulated MAP Kinases, Humans, Interleukin-13, Mast Cells, Mice, Mice, Inbred C57BL, Purines, Receptor, Adenosine A2B, Signal Transduction, Vascular Endothelial Growth Factor A, Xanthines, p38 Mitogen-Activated Protein Kinases
Added December 10, 2013
0 Communities
3 Members
0 Resources
20 MeSH Terms
Effect of A2B adenosine receptor gene ablation on adenosine-dependent regulation of proinflammatory cytokines.
Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Blackburn MR, Biaggioni I, Feoktistov I
(2008) J Pharmacol Exp Ther 324: 694-700
MeSH Terms: Adenosine, Adenosine A2 Receptor Antagonists, Animals, Cytokines, Inflammation, Macrophages, Peritoneal, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptor, Adenosine A2B
Added December 10, 2013
0 Communities
2 Members
0 Resources
10 MeSH Terms
Tachycardia caused by A2A adenosine receptor agonists is mediated by direct sympathoexcitation in awake rats.
Dhalla AK, Wong MY, Wang WQ, Biaggioni I, Belardinelli L
(2006) J Pharmacol Exp Ther 316: 695-702
MeSH Terms: Adenosine A2 Receptor Agonists, Adenosine A2 Receptor Antagonists, Animals, Blood Pressure, Dose-Response Relationship, Drug, Heart Rate, Male, Norepinephrine, Purines, Pyrazoles, Rats, Rats, Sprague-Dawley, Sympathetic Nervous System, Tachycardia, Time Factors, Triazines, Triazoles
Added December 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
A(2B) adenosine receptors increase cytokine release by bronchial smooth muscle cells.
Zhong H, Belardinelli L, Maa T, Feoktistov I, Biaggioni I, Zeng D
(2004) Am J Respir Cell Mol Biol 30: 118-25
MeSH Terms: Adenosine A2 Receptor Antagonists, Base Sequence, Bronchi, Cells, Cultured, Cytokines, DNA Primers, Enzyme-Linked Immunosorbent Assay, Humans, Muscle, Smooth, RNA, Messenger, Receptor, Adenosine A2B
Added December 10, 2013
0 Communities
2 Members
0 Resources
11 MeSH Terms