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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 21

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APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway.
Saito-Diaz K, Benchabane H, Tiwari A, Tian A, Li B, Thompson JJ, Hyde AS, Sawyer LM, Jodoin JN, Santos E, Lee LA, Coffey RJ, Beauchamp RD, Williams CS, Kenworthy AK, Robbins DJ, Ahmed Y, Lee E
(2018) Dev Cell 44: 566-581.e8
MeSH Terms: Adenomatous Polyposis Coli Protein, Animals, Cells, Cultured, Clathrin, Drosophila melanogaster, Endocytosis, Female, Humans, Infant, Ligands, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Middle Aged, Wnt Proteins, Wnt Signaling Pathway, beta Catenin
Added March 14, 2018
0 Communities
4 Members
0 Resources
18 MeSH Terms
Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.
Chung L, Thiele Orberg E, Geis AL, Chan JL, Fu K, DeStefano Shields CE, Dejea CM, Fathi P, Chen J, Finard BB, Tam AJ, McAllister F, Fan H, Wu X, Ganguly S, Lebid A, Metz P, Van Meerbeke SW, Huso DL, Wick EC, Pardoll DM, Wan F, Wu S, Sears CL, Housseau F
(2018) Cell Host Microbe 23: 203-214.e5
MeSH Terms: Adenomatous Polyposis Coli Protein, Animals, Bacterial Toxins, Bacteroides fragilis, Carcinogenesis, Cell Line, Tumor, Colon, Colorectal Neoplasms, Enzyme Activation, Epithelial Cells, Female, Gene Deletion, HT29 Cells, Humans, Inflammation, Interleukin-17, Male, Metalloendopeptidases, Mice, Mice, Inbred C57BL, Mice, Knockout, Myeloid Cells, Receptors, Interleukin-17, Receptors, Interleukin-8B, STAT3 Transcription Factor, Transcription Factor RelA
Added March 20, 2018
0 Communities
1 Members
0 Resources
26 MeSH Terms
p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia.
Short SP, Kondo J, Smalley-Freed WG, Takeda H, Dohn MR, Powell AE, Carnahan RH, Washington MK, Tripathi M, Payne DM, Jenkins NA, Copeland NG, Coffey RJ, Reynolds AB
(2017) J Clin Invest 127: 4462-4476
MeSH Terms: Adenomatous Polyposis Coli Protein, Animals, Catenins, Haploinsufficiency, Intestinal Neoplasms, Mice, Mice, Knockout, rho-Associated Kinases
Added March 14, 2018
0 Communities
2 Members
0 Resources
8 MeSH Terms
Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase.
Wang Z, Tacchelly-Benites O, Yang E, Thorne CA, Nojima H, Lee E, Ahmed Y
(2016) Genetics 203: 269-81
MeSH Terms: Adenomatous Polyposis Coli Protein, Animals, Axin Protein, Drosophila, Genotype, Mitosis, Protein Interaction Domains and Motifs, Protein Stability, Tankyrases, Wnt Proteins, Wnt Signaling Pathway, Xenopus
Added February 13, 2017
0 Communities
1 Members
0 Resources
12 MeSH Terms
Activation of Wnt/β-catenin signaling in a subpopulation of murine prostate luminal epithelial cells induces high grade prostate intraepithelial neoplasia.
Valkenburg KC, Yu X, De Marzo AM, Spiering TJ, Matusik RJ, Williams BO
(2014) Prostate 74: 1506-20
MeSH Terms: Adenomatous Polyposis Coli Protein, Animals, Castration, Enzyme-Linked Immunosorbent Assay, Epithelial Cells, Immunohistochemistry, Male, Mice, Prostate, Prostatic Intraepithelial Neoplasia, Prostatic Neoplasms, Reverse Transcriptase Polymerase Chain Reaction, Tamoxifen, Wnt Proteins, Wnt Signaling Pathway, beta Catenin
Added January 20, 2015
1 Communities
1 Members
0 Resources
16 MeSH Terms
Claudin-1 overexpression in intestinal epithelial cells enhances susceptibility to adenamatous polyposis coli-mediated colon tumorigenesis.
Pope JL, Ahmad R, Bhat AA, Washington MK, Singh AB, Dhawan P
(2014) Mol Cancer 13: 167
MeSH Terms: Adenomatous Polyposis Coli, Adenomatous Polyposis Coli Protein, Animals, Cell Transformation, Neoplastic, Claudin-1, Colonic Neoplasms, Epithelial Cells, Gene Expression Regulation, Neoplastic, Interleukin-23 Subunit p19, Intestinal Mucosa, Intestines, Mice, Mucin-2
Added December 8, 2014
1 Communities
1 Members
0 Resources
13 MeSH Terms
The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules.
Yasuda K, Zhang H, Loiselle D, Haystead T, Macara IG, Mili S
(2013) J Cell Biol 203: 737-46
MeSH Terms: Adenomatous Polyposis Coli Protein, Animals, Cytoplasmic Granules, Mice, NIH 3T3 Cells, Protein Biosynthesis, RNA, Messenger, RNA-Binding Protein FUS, Ribonucleoproteins
Added March 20, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
PIK3CA and APC mutations are synergistic in the development of intestinal cancers.
Deming DA, Leystra AA, Nettekoven L, Sievers C, Miller D, Middlebrooks M, Clipson L, Albrecht D, Bacher J, Washington MK, Weichert J, Halberg RB
(2014) Oncogene 33: 2245-54
MeSH Terms: Adenocarcinoma, Adenomatous Polyposis Coli Protein, Animals, Cell Nucleus, Class I Phosphatidylinositol 3-Kinases, Colorectal Neoplasms, Cyclin D1, Disease Models, Animal, Epistasis, Genetic, Female, Gene Expression, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microsatellite Instability, Phosphatidylinositol 3-Kinases, Tumor Burden, Wnt Signaling Pathway, beta Catenin
Added April 12, 2016
0 Communities
1 Members
0 Resources
21 MeSH Terms
The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor.
Powell AE, Wang Y, Li Y, Poulin EJ, Means AL, Washington MK, Higginbotham JN, Juchheim A, Prasad N, Levy SE, Guo Y, Shyr Y, Aronow BJ, Haigis KM, Franklin JL, Coffey RJ
(2012) Cell 149: 146-58
MeSH Terms: Adenoma, Adenomatous Polyposis Coli Protein, Animals, Colon, ErbB Receptors, Gene Expression Profiling, Genes, Tumor Suppressor, Humans, Intestinal Neoplasms, Intestine, Small, Membrane Glycoproteins, Mice, Nerve Tissue Proteins, Receptors, G-Protein-Coupled, Signal Transduction, Stem Cells
Added July 19, 2013
3 Communities
5 Members
0 Resources
16 MeSH Terms
Topoisomerase IIalpha binding domains of adenomatous polyposis coli influence cell cycle progression and aneuploidy.
Wang Y, Coffey RJ, Osheroff N, Neufeld KL
(2010) PLoS One 5: e9994
MeSH Terms: Adenomatous Polyposis Coli, Adenomatous Polyposis Coli Protein, Aneuploidy, Antigens, Neoplasm, Binding Sites, Cell Cycle, Cell Line, Tumor, Codon, Nonsense, DNA Topoisomerases, Type II, DNA-Binding Proteins, Epithelial Cells, G2 Phase, Humans, Repetitive Sequences, Nucleic Acid, beta Catenin
Added August 12, 2010
1 Communities
1 Members
0 Resources
15 MeSH Terms