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Results: 1 to 9 of 9

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Myt Transcription Factors Prevent Stress-Response Gene Overactivation to Enable Postnatal Pancreatic β Cell Proliferation, Function, and Survival.
Hu R, Walker E, Huang C, Xu Y, Weng C, Erickson GE, Coldren A, Yang X, Brissova M, Kaverina I, Balamurugan AN, Wright CVE, Li Y, Stein R, Gu G
(2020) Dev Cell 53: 390-405.e10
MeSH Terms: Activating Transcription Factor 4, Animals, Cell Proliferation, DNA-Binding Proteins, Diabetes Mellitus, Female, Heat-Shock Proteins, Humans, Insulin Secretion, Insulin-Secreting Cells, Male, Mice, Mice, Knockout, Stress, Physiological, Transcription Factors
Added May 6, 2020
3 Communities
2 Members
0 Resources
15 MeSH Terms
The loss of activating transcription factor 4 (ATF4) reduces bone toughness and fracture toughness.
Makowski AJ, Uppuganti S, Wadeer SA, Whitehead JM, Rowland BJ, Granke M, Mahadevan-Jansen A, Yang X, Nyman JS
(2014) Bone 62: 1-9
MeSH Terms: Activating Transcription Factor 4, Animals, Bone Matrix, Bone and Bones, Calcification, Physiologic, Compressive Strength, Femur, Fractures, Bone, Gene Deletion, Linear Models, Lumbar Vertebrae, Mice, Organ Specificity, Time Factors, X-Ray Microtomography
Added March 24, 2014
1 Communities
4 Members
0 Resources
15 MeSH Terms
Transforming growth factor β suppresses osteoblast differentiation via the vimentin activating transcription factor 4 (ATF4) axis.
Lian N, Lin T, Liu W, Wang W, Li L, Sun S, Nyman JS, Yang X
(2012) J Biol Chem 287: 35975-84
MeSH Terms: Activating Transcription Factor 4, Animals, COS Cells, Cell Differentiation, Cell Line, Tumor, Chlorocebus aethiops, Mice, Mice, Knockout, Osteoblasts, Osteocalcin, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Rats, Signal Transduction, Smad Proteins, TOR Serine-Threonine Kinases, Transcription, Genetic, Transforming Growth Factor beta, Up-Regulation, Vimentin
Added October 31, 2013
1 Communities
1 Members
0 Resources
20 MeSH Terms
Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh.
Wang W, Lian N, Ma Y, Li L, Gallant RC, Elefteriou F, Yang X
(2012) Development 139: 601-11
MeSH Terms: Activating Transcription Factor 4, Animals, Bone Development, Cell Differentiation, Cells, Cultured, Chondrocytes, Collagen Type II, Female, Growth Plate, Hedgehog Proteins, Integrin-Binding Sialoprotein, Male, Mice, Mice, Transgenic, Osteoblasts, Osteocalcin, Osteogenesis
Added November 14, 2013
0 Communities
2 Members
0 Resources
17 MeSH Terms
Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription.
Wang W, Lian N, Li L, Moss HE, Wang W, Perrien DS, Elefteriou F, Yang X
(2009) Development 136: 4143-53
MeSH Terms: Activating Transcription Factor 4, Animals, Cell Differentiation, Cell Proliferation, Chondrocytes, Collagen Type II, Collagen Type X, Growth Plate, Hedgehog Proteins, Mice, Mice, Knockout, Organ Culture Techniques, Osteogenesis, Receptor, Parathyroid Hormone, Type 1, Transcriptional Activation
Added November 14, 2013
1 Communities
4 Members
0 Resources
15 MeSH Terms
Vimentin inhibits ATF4-mediated osteocalcin transcription and osteoblast differentiation.
Lian N, Wang W, Li L, Elefteriou F, Yang X
(2009) J Biol Chem 284: 30518-25
MeSH Terms: Activating Transcription Factor 4, Animals, Biomarkers, Cell Differentiation, Cells, Cultured, Chromatography, Affinity, Osteoblasts, Osteocalcin, Osteogenesis, Protein Binding, Rats, Transcription, Genetic, Vimentin
Added November 14, 2013
0 Communities
2 Members
0 Resources
13 MeSH Terms
ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae.
Elefteriou F, Benson MD, Sowa H, Starbuck M, Liu X, Ron D, Parada LF, Karsenty G
(2006) Cell Metab 4: 441-51
MeSH Terms: Activating Transcription Factor 4, Amino Acids, Animals, Biological Transport, Active, Bone Diseases, Developmental, Bone Resorption, Cell Differentiation, Coffin-Lowry Syndrome, Collagen, Cyclic AMP-Dependent Protein Kinases, Dietary Proteins, Mice, Mice, Knockout, Neurofibromin 1, Osteoblasts, Osteoclasts, Osteogenesis, RANK Ligand, Ribosomal Protein S6 Kinases, 90-kDa
Added November 14, 2013
0 Communities
1 Members
0 Resources
19 MeSH Terms
Leptin regulation of bone resorption by the sympathetic nervous system and CART.
Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G
(2005) Nature 434: 514-20
MeSH Terms: Activating Transcription Factor 4, Amino Acid Sequence, Animals, Bone Resorption, Carrier Proteins, Cell Line, Child, Child, Preschool, Cyclic AMP-Dependent Protein Kinases, Gene Deletion, Humans, Leptin, Male, Membrane Glycoproteins, Mice, Models, Neurological, Neoplasm Proteins, Nerve Tissue Proteins, Osteoblasts, Osteogenesis, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B, Receptor, Melanocortin, Type 4, Receptors, Adrenergic, beta-2, Receptors, Leptin, Response Elements, Signal Transduction, Sympathetic Nervous System, Transcription Factors
Added November 14, 2013
0 Communities
1 Members
0 Resources
29 MeSH Terms
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response.
Jiang HY, Wek SA, McGrath BC, Lu D, Hai T, Harding HP, Wang X, Ron D, Cavener DR, Wek RC
(2004) Mol Cell Biol 24: 1365-77
MeSH Terms: Activating Transcription Factor 3, Activating Transcription Factor 4, Animals, CCAAT-Enhancer-Binding Proteins, Eukaryotic Initiation Factor-2, Mice, Phosphorylation, Phosphotransferases, Protein Kinases, Protein Serine-Threonine Kinases, RNA, Messenger, Transcription Factor CHOP, Transcription Factors, eIF-2 Kinase
Added August 13, 2010
1 Communities
0 Members
0 Resources
14 MeSH Terms